Toll-like receptor 4

mammalian protein found in Mus musculus

Protein protein Q14914104

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Toll-like receptor 4

Summary

Toll-like receptor 4 is a protein^[1].

Key Facts

Toll-like receptor 4's instance of is recorded as protein^[2].
Toll-like receptor 4's physically interacts with is recorded as paclitaxel^[3].
Toll-like receptor 4's UniProt protein ID is recorded as Q9QUK6^[4].
Toll-like receptor 4's part of is recorded as Toll/interleukin-1 receptor homology (TIR) domain superfamily^[5].
Toll-like receptor 4's part of is recorded as Leucine-rich repeat domain superfamily^[6].
Toll-like receptor 4's part of is recorded as membrane protein^[7].
Toll-like receptor 4's part of is recorded as Toll/interleukin-1 receptor homology (TIR) domain, protein family^[8].
Toll-like receptor 4's part of is recorded as Cysteine-rich flanking region, C-terminal domain, protein family^[9].
Toll-like receptor 4's part of is recorded as Leucine-rich repeat, typical subtype, protein family^[10].
Toll-like receptor 4's part of is recorded as Leucine-rich repeat, protein family^[11].
Toll-like receptor 4's has part is recorded as Leucine-rich repeat^[12].
Toll-like receptor 4's has part is recorded as cysteine-rich flanking region, C-terminal^[13].
Toll-like receptor 4's has part is recorded as leucine-rich repeat, typical subtype^[14].
Toll-like receptor 4's has part is recorded as Toll/interleukin-1 receptor homology (TIR) domain^[15].
Toll-like receptor 4's RefSeq protein ID is recorded as NP_067272^[16].
Toll-like receptor 4's RefSeq protein ID is recorded as XP_036019857^[17].
Toll-like receptor 4's PDB structure ID is recorded as 2Z64^[18].
Toll-like receptor 4's PDB structure ID is recorded as 3VQ1^[19].
Toll-like receptor 4's PDB structure ID is recorded as 3VQ2^[20].
Toll-like receptor 4's PDB structure ID is recorded as 5IJB^[21].
Toll-like receptor 4's PDB structure ID is recorded as 5IJD^[22].
Toll-like receptor 4's PDB structure ID is recorded as 5IJC^[23].
Toll-like receptor 4's molecular function is recorded as protein binding^[24].
Toll-like receptor 4's molecular function is recorded as transmembrane signaling receptor activity^[25].
Toll-like receptor 4's molecular function is recorded as lipopolysaccharide binding^[26].

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Quick Facts

Instance of protein

Part of Toll/interleukin-1 receptor homology (TIR) domain superfamily, Leucine-rich repeat domain superfamily, membrane protein, Toll/interleukin-1 receptor homology (TIR) domain, protein family, Cysteine-rich flanking region, C-terminal domain, protein family, Leucine-rich repeat, typical subtype, protein family, Leucine-rich repeat, protein family

Properties

Biological process positive regulation of MHC class II biosynthetic process, positive regulation of JNK cascade, cellular response to mechanical stimulus, positive regulation of interleukin-8 production, positive regulation of ERK1 and ERK2 cascade, positive regulation of platelet activation, positive regulation of interleukin-1 production, positive regulation of stress-activated MAPK cascade, positive regulation of NLRP3 inflammasome complex assembly, positive regulation of interleukin-12 production, positive regulation of interferon-alpha production, activation of NF-kappaB-inducing kinase activity, I-kappaB phosphorylation, positive regulation of nitric-oxide synthase biosynthetic process, positive regulation of B cell proliferation, positive regulation of interleukin-6 production, activation of innate immune response, positive regulation of tumor necrosis factor production, negative regulation of tumor necrosis factor production, innate immune response, inflammatory response, negative regulation of interleukin-17 production, positive regulation of interferon-beta production, mast cell activation, toll-like receptor 4 signaling pathway, positive regulation of macrophage cytokine production, positive regulation of interleukin-10 production, immune system process, astrocyte development, intestinal epithelial structure maintenance, positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway, response to lipopolysaccharide, cellular response to lipoteichoic acid, positive regulation of NF-kappaB transcription factor activity, negative regulation of interleukin-23 production, regulation of inflammatory response, positive regulation of chemokine production, lipopolysaccharide-mediated signaling pathway, positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway, negative regulation of interferon-gamma production, response to bacterium, B cell proliferation involved in immune response, positive regulation of nitric oxide biosynthetic process, negative regulation of interleukin-6 production, positive regulation of interferon-gamma production, nitric oxide production involved in inflammatory response, MyD88-dependent toll-like receptor signaling pathway, regulation of dendritic cell cytokine production, positive regulation of gene expression, defense response to Gram-negative bacterium, positive regulation of I-kappaB kinase/NF-kappaB signaling, negative regulation of ERK1 and ERK2 cascade, macrophage activation, detection of lipopolysaccharide, cellular response to lipopolysaccharide, positive regulation of lymphocyte proliferation, signal transduction, positive regulation of transcription by RNA polymerase II, toll-like receptor signaling pathway, microglial cell activation, toll-like receptor signaling pathway, MyD88-dependent toll-like receptor signaling pathway, innate immune response-activating signal transduction, leukotriene metabolic process, inflammatory response, response to oxidative stress, positive regulation of gene expression, TRIF-dependent toll-like receptor signaling pathway, positive regulation of macrophage activation, positive regulation of apoptotic process, positive regulation of DNA binding, positive regulation of nitric oxide biosynthetic process, response to ethanol, positive regulation of inflammatory response, positive regulation of peptidyl-tyrosine phosphorylation, defense response to Gram-negative bacterium, detection of temperature stimulus involved in sensory perception of pain, detection of mechanical stimulus involved in sensory perception of pain, positive regulation of DNA-binding transcription factor activity, regulation of sensory perception of pain, response to fatty acid, cellular response to lipopolysaccharide, cellular response to interferon-gamma, negative regulation of cold-induced thermogenesis, cellular response to oxidised low-density lipoprotein particle stimulus, positive regulation of cytokine production involved in inflammatory response, positive regulation of NIK/NF-kappaB signaling, positive regulation of oxidative stress-induced neuron death, positive regulation of reactive oxygen species biosynthetic process, positive regulation of cellular response to macrophage colony-stimulating factor stimulus, cellular response to amyloid-beta, phagocytosis, MyD88-dependent toll-like receptor signaling pathway, phagocytosis, defense response to Gram-negative bacterium

Cell component cytoplasm, membrane, perinuclear region of cytoplasm, cell surface, integral component of membrane, plasma membrane, intrinsic component of plasma membrane, lipopolysaccharide receptor complex, external side of plasma membrane, integral component of plasma membrane, intracellular anatomical structure, receptor complex, endosome, early endosome, plasma membrane, membrane raft, phagocytic cup, phagocytic cup

Encoded by Tlr4

Exact match identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov

Found in taxon house mouse

Has part(s) Leucine-rich repeat, cysteine-rich flanking region, C-terminal, leucine-rich repeat, typical subtype, Toll/interleukin-1 receptor homology (TIR) domain

Imported from wholeness_audit_2026-05-02

Molecular function protein binding, transmembrane signaling receptor activity, lipopolysaccharide binding, lipopolysaccharide immune receptor activity, signaling receptor binding, identical protein binding, phosphatidylinositol 3-kinase binding, protein heterodimerization activity

Physically interacts with paclitaxel

External References (4)

Ensembl protein id ENSMUSP00000102988, ENSMUSP00000045770

Pdb structure id 2Z64, 3VQ1, 3VQ2, 5IJB, 5IJD, 5IJC

Refseq protein id NP_067272, XP_036019857

Uniprot protein id Q9QUK6

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Toll-like receptor 4 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Toll-like receptor 4 — physically interacts with (P129): paclitaxel. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ Toll-like receptor 4 — UniProt protein ID (P352): Q9QUK6. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Toll-like receptor 4 — part of (P361): Toll/interleukin-1 receptor homology (TIR) domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Toll-like receptor 4 — part of (P361): Leucine-rich repeat domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Toll-like receptor 4 — part of (P361): membrane protein. wikidata.org.
[8] ↑ Toll-like receptor 4 — part of (P361): Toll/interleukin-1 receptor homology (TIR) domain, protein family. wikidata.org.
[9] ↑ Toll-like receptor 4 — part of (P361): Cysteine-rich flanking region, C-terminal domain, protein family. wikidata.org.
[10] ↑ Toll-like receptor 4 — part of (P361): Leucine-rich repeat, typical subtype, protein family. wikidata.org.
[11] ↑ Toll-like receptor 4 — part of (P361): Leucine-rich repeat, protein family. wikidata.org.
[12] ↑ Toll-like receptor 4 — has part(s) (P527): Leucine-rich repeat. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Toll-like receptor 4 — has part(s) (P527): cysteine-rich flanking region, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Toll-like receptor 4 — has part(s) (P527): leucine-rich repeat, typical subtype. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Toll-like receptor 4 — has part(s) (P527): Toll/interleukin-1 receptor homology (TIR) domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Toll-like receptor 4 — RefSeq protein ID (P637): NP_067272. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ Toll-like receptor 4 — RefSeq protein ID (P637): XP_036019857. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ Toll-like receptor 4 — PDB structure ID (P638): 2Z64. Q905695. Retrieved 2016-08-09. wikidata.org.
[19] ↑ Toll-like receptor 4 — PDB structure ID (P638): 3VQ1. Q905695. Retrieved 2016-08-09. wikidata.org.
[20] ↑ Toll-like receptor 4 — PDB structure ID (P638): 3VQ2. Q905695. Retrieved 2016-08-09. wikidata.org.
[21] ↑ Toll-like receptor 4 — PDB structure ID (P638): 5IJB. Q905695. Retrieved 2016-08-09. wikidata.org.
[22] ↑ Toll-like receptor 4 — PDB structure ID (P638): 5IJD. Q905695. Retrieved 2016-08-09. wikidata.org.
[23] ↑ Toll-like receptor 4 — PDB structure ID (P638): 5IJC. Q905695. Retrieved 2016-08-09. wikidata.org.
[24] ↑ Toll-like receptor 4 — molecular function (P680): protein binding. Q905695. Retrieved 2016-08-09. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Toll-like receptor 4 — molecular function (P680): transmembrane signaling receptor activity. Q905695. Retrieved 2016-08-09. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Toll-like receptor 4 — molecular function (P680): lipopolysaccharide binding. Q905695. Retrieved 2016-08-09. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Toll-like receptor 4 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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BibTeX

@misc{4ortxyz_toll-like-receptor-4_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Toll-like receptor 4}}, year = {2026}, url = {https://4ort.xyz/entity/toll-like-receptor-4}, note = {Accessed: 2026-05-03}}

LLM prompt

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Canonical URL: https://4ort.xyz/entity/toll-like-receptor-4 · Last refreshed: May 3, 2026