Toll-like receptor 2

mammalian protein found in Mus musculus

Protein protein Q14907444

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Toll-like receptor 2

Summary

Toll-like receptor 2 is a protein^[1].

Key Facts

Toll-like receptor 2's instance of is recorded as protein^[2].
Toll-like receptor 2's UniProt protein ID is recorded as Q9QUN7^[3].
Toll-like receptor 2's part of is recorded as Toll/interleukin-1 receptor homology (TIR) domain superfamily^[4].
Toll-like receptor 2's part of is recorded as Leucine-rich repeat domain superfamily^[5].
Toll-like receptor 2's part of is recorded as toll-like receptor 2^[6].
Toll-like receptor 2's part of is recorded as membrane protein^[7].
Toll-like receptor 2's part of is recorded as Toll/interleukin-1 receptor homology (TIR) domain, protein family^[8].
Toll-like receptor 2's part of is recorded as Cysteine-rich flanking region, C-terminal domain, protein family^[9].
Toll-like receptor 2's part of is recorded as Leucine-rich repeat, typical subtype, protein family^[10].
Toll-like receptor 2's part of is recorded as Leucine-rich repeat, protein family^[11].
Toll-like receptor 2's has part is recorded as Leucine-rich repeat^[12].
Toll-like receptor 2's has part is recorded as cysteine-rich flanking region, C-terminal^[13].
Toll-like receptor 2's has part is recorded as leucine-rich repeat, typical subtype^[14].
Toll-like receptor 2's has part is recorded as Toll/interleukin-1 receptor homology (TIR) domain^[15].
Toll-like receptor 2's RefSeq protein ID is recorded as NP_036035^[16].
Toll-like receptor 2's RefSeq protein ID is recorded as XP_006501523^[17].
Toll-like receptor 2's RefSeq protein ID is recorded as XP_030108471^[18].
Toll-like receptor 2's PDB structure ID is recorded as 2Z81^[19].
Toll-like receptor 2's PDB structure ID is recorded as 2Z82^[20].
Toll-like receptor 2's PDB structure ID is recorded as 3A79^[21].
Toll-like receptor 2's PDB structure ID is recorded as 3A7B^[22].
Toll-like receptor 2's PDB structure ID is recorded as 3A7C^[23].
Toll-like receptor 2's PDB structure ID is recorded as 5D3I^[24].
Toll-like receptor 2's molecular function is recorded as diacyl lipopeptide binding^[25].
Toll-like receptor 2's molecular function is recorded as lipopolysaccharide binding^[26].

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Quick Facts

Instance of protein

Part of Toll/interleukin-1 receptor homology (TIR) domain superfamily, Leucine-rich repeat domain superfamily, toll-like receptor 2, membrane protein, Toll/interleukin-1 receptor homology (TIR) domain, protein family, Cysteine-rich flanking region, C-terminal domain, protein family, Leucine-rich repeat, typical subtype, protein family, Leucine-rich repeat, protein family

Properties

Biological process detection of diacyl bacterial lipopeptide, positive regulation of xenophagy, cellular response to triacyl bacterial lipopeptide, response to peptidoglycan, positive regulation of interleukin-8 production, positive regulation of ERK1 and ERK2 cascade, induction by symbiont of defense-related host nitric oxide production, cellular response to peptidoglycan, defense response to Gram-positive bacterium, positive regulation of interleukin-18 production, positive regulation of interleukin-12 production, cellular response to diacyl bacterial lipopeptide, I-kappaB phosphorylation, positive regulation of nitric-oxide synthase biosynthetic process, detection of triacyl bacterial lipopeptide, positive regulation of Wnt signaling pathway, positive regulation of interleukin-6 production, positive regulation of tumor necrosis factor production, innate immune response, negative regulation of interleukin-17 production, interleukin-10 production, positive regulation of interferon-beta production, positive regulation of toll-like receptor signaling pathway, positive regulation of inflammatory response, positive regulation of macrophage cytokine production, positive regulation of leukocyte migration, immune system process, toll-like receptor 2 signaling pathway, cellular response to lipoteichoic acid, positive regulation of NF-kappaB transcription factor activity, positive regulation of chemokine production, negative regulation of interleukin-12 production, cellular response to bacterial lipopeptide, response to bacterium, positive regulation of nitric oxide biosynthetic process, MyD88-dependent toll-like receptor signaling pathway, regulation of dendritic cell cytokine production, positive regulation of NIK/NF-kappaB signaling, response to molecule of fungal origin, positive regulation of gene expression, cell surface pattern recognition receptor signaling pathway, chloramphenicol transmembrane transport, response to molecule of bacterial origin, signal transduction, positive regulation of transcription by RNA polymerase II, inflammatory response, cell activation, microglial cell activation, toll-like receptor signaling pathway, leukotriene metabolic process, inflammatory response, learning, negative regulation of cell population proliferation, microglia development, negative regulation of actin filament polymerization, central nervous system myelin formation, response to bacterial lipoprotein, tumor necrosis factor production, positive regulation of interleukin-10 production, nitric oxide metabolic process, positive regulation of oligodendrocyte differentiation, positive regulation of inflammatory response, negative regulation of phagocytosis, negative regulation of synapse assembly, response to fatty acid, cellular response to interferon-gamma, positive regulation of NIK/NF-kappaB signaling, positive regulation of cellular response to macrophage colony-stimulating factor stimulus, defense response

Cell component cytoplasm, membrane, Toll-like receptor 1-Toll-like receptor 2 protein complex, cell surface, membrane raft, integral component of membrane, Golgi apparatus, Toll-like receptor 2-Toll-like receptor 6 protein complex, plasma membrane, phagocytic vesicle membrane, cytoplasmic vesicle, external side of plasma membrane, intrinsic component of plasma membrane, integral component of plasma membrane, cell projection, cell body

Encoded by Tlr2

Found in taxon house mouse

Has part(s) Leucine-rich repeat, cysteine-rich flanking region, C-terminal, leucine-rich repeat, typical subtype, Toll/interleukin-1 receptor homology (TIR) domain

Imported from wholeness_audit_2026-05-02

Molecular function diacyl lipopeptide binding, lipopolysaccharide binding, protein binding, peptidoglycan binding, pattern recognition receptor activity, Toll-like receptor binding, lipoteichoic acid binding, triacyl lipopeptide binding, protein heterodimerization activity, amyloid-beta binding, identical protein binding, protein-containing complex binding, lipopeptide binding

External References (4)

Ensembl protein id ENSMUSP00000029623

Pdb structure id 2Z81, 2Z82, 3A79, 3A7B, 3A7C, 5D3I

Refseq protein id NP_036035, XP_006501523, XP_030108471

Uniprot protein id Q9QUN7

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Toll-like receptor 2 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Toll-like receptor 2 — UniProt protein ID (P352): Q9QUN7. Q905695. Retrieved 2022-05-25. wikidata.org.
[4] ↑ Toll-like receptor 2 — part of (P361): Toll/interleukin-1 receptor homology (TIR) domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Toll-like receptor 2 — part of (P361): Leucine-rich repeat domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Toll-like receptor 2 — part of (P361): toll-like receptor 2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Toll-like receptor 2 — part of (P361): membrane protein. wikidata.org.
[8] ↑ Toll-like receptor 2 — part of (P361): Toll/interleukin-1 receptor homology (TIR) domain, protein family. wikidata.org.
[9] ↑ Toll-like receptor 2 — part of (P361): Cysteine-rich flanking region, C-terminal domain, protein family. wikidata.org.
[10] ↑ Toll-like receptor 2 — part of (P361): Leucine-rich repeat, typical subtype, protein family. wikidata.org.
[11] ↑ Toll-like receptor 2 — part of (P361): Leucine-rich repeat, protein family. wikidata.org.
[12] ↑ Toll-like receptor 2 — has part(s) (P527): Leucine-rich repeat. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Toll-like receptor 2 — has part(s) (P527): cysteine-rich flanking region, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Toll-like receptor 2 — has part(s) (P527): leucine-rich repeat, typical subtype. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Toll-like receptor 2 — has part(s) (P527): Toll/interleukin-1 receptor homology (TIR) domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Toll-like receptor 2 — RefSeq protein ID (P637): NP_036035. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ Toll-like receptor 2 — RefSeq protein ID (P637): XP_006501523. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ Toll-like receptor 2 — RefSeq protein ID (P637): XP_030108471. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ Toll-like receptor 2 — PDB structure ID (P638): 2Z81. Q905695. Retrieved 2016-08-09. wikidata.org.
[20] ↑ Toll-like receptor 2 — PDB structure ID (P638): 2Z82. Q905695. Retrieved 2016-08-09. wikidata.org.
[21] ↑ Toll-like receptor 2 — PDB structure ID (P638): 3A79. Q905695. Retrieved 2016-08-09. wikidata.org.
[22] ↑ Toll-like receptor 2 — PDB structure ID (P638): 3A7B. Q905695. Retrieved 2016-08-09. wikidata.org.
[23] ↑ Toll-like receptor 2 — PDB structure ID (P638): 3A7C. Q905695. Retrieved 2016-08-09. wikidata.org.
[24] ↑ Toll-like receptor 2 — PDB structure ID (P638): 5D3I. Q905695. Retrieved 2016-08-09. wikidata.org.
[25] ↑ Toll-like receptor 2 — molecular function (P680): diacyl lipopeptide binding. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Toll-like receptor 2 — molecular function (P680): lipopolysaccharide binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Toll-like receptor 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

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BibTeX

@misc{4ortxyz_toll-like-receptor-2-q14907444_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Toll-like receptor 2}}, year = {2026}, url = {https://4ort.xyz/entity/toll-like-receptor-2-q14907444}, note = {Accessed: 2026-05-03}}

LLM prompt

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