Toll interacting protein

mammalian protein found in Homo sapiens

Protein protein Q21117391

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Toll interacting protein

Summary

Toll interacting protein is a protein^[1].

Key Facts

Toll interacting protein's instance of is recorded as protein^[2].
Toll interacting protein's UniProt protein ID is recorded as Q9H0E2^[3].
Toll interacting protein's part of is recorded as UBA-like superfamily^[4].
Toll interacting protein's part of is recorded as C2 domain superfamily^[5].
Toll interacting protein's part of is recorded as C2 domain, protein family^[6].
Toll interacting protein's part of is recorded as Ubiquitin system component Cue, protein family^[7].
Toll interacting protein's part of is recorded as Toll-interacting protein, C2 domain, protein family^[8].
Toll interacting protein's has part is recorded as C2 domain^[9].
Toll interacting protein's has part is recorded as Ubiquitin system component Cue^[10].
Toll interacting protein's has part is recorded as Toll-interacting protein, C2 domain^[11].
Toll interacting protein's RefSeq protein ID is recorded as NP_001305441^[12].
Toll interacting protein's RefSeq protein ID is recorded as NP_001305443^[13].
Toll interacting protein's RefSeq protein ID is recorded as NP_001305444^[14].
Toll interacting protein's RefSeq protein ID is recorded as NP_001305445^[15].
Toll interacting protein's RefSeq protein ID is recorded as NP_061882^[16].
Toll interacting protein's RefSeq protein ID is recorded as XP_016873420^[17].
Toll interacting protein's PDB structure ID is recorded as 1WGL^[18].
Toll interacting protein's PDB structure ID is recorded as 2N31^[19].
Toll interacting protein's molecular function is recorded as signal transducer activity^[20].
Toll interacting protein's molecular function is recorded as Toll-like receptor binding^[21].
Toll interacting protein's molecular function is recorded as SUMO binding^[22].
Toll interacting protein's molecular function is recorded as kinase binding^[23].
Toll interacting protein's molecular function is recorded as protein binding^[24].
Toll interacting protein's molecular function is recorded as interleukin-1, type I receptor binding^[25].
Toll interacting protein's molecular function is recorded as ubiquitin protein ligase binding^[26].

⭐ Popularity Graph

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Quick Facts

Instance of protein

Part of UBA-like superfamily, C2 domain superfamily, C2 domain, protein family, Ubiquitin system component Cue, protein family, Toll-interacting protein, C2 domain, protein family

Properties

Biological process intracellular signal transduction, epithelial cell differentiation, phosphorylation, immune system process, leukocyte activation, cell-cell signaling, positive regulation of protein sumoylation, autophagy, protein localization to endosome, innate immune response, inflammatory response, signal transduction, ubiquitin-dependent protein catabolic process, neutrophil degranulation, interleukin-1-mediated signaling pathway

Cell component interleukin-18 receptor complex, cytosol, nuclear body, perinuclear region of cytoplasm, interleukin-1 receptor complex, extracellular exosome, extracellular region, cytoplasm, azurophil granule lumen, specific granule lumen, cytoplasm, extracellular exosome

Encoded by TOLLIP

Found in taxon Homo sapiens

Has part(s) C2 domain, Ubiquitin system component Cue, Toll-interacting protein, C2 domain

Imported from wholeness_audit_2026-05-02

Molecular function signal transducer activity, Toll-like receptor binding, SUMO binding, kinase binding, protein binding, interleukin-1, type I receptor binding, ubiquitin protein ligase binding, ubiquitin conjugating enzyme binding, ubiquitin binding

External References (4)

Ensembl protein id ENSP00000314733, ENSP00000434035, ENSP00000263646, ENSP00000432668, ENSP00000432778, ENSP00000434494, ENSP00000436393

Pdb structure id 1WGL, 2N31

Refseq protein id NP_001305441, NP_001305443, NP_001305444, NP_001305445, NP_061882, XP_016873420

Uniprot protein id Q9H0E2

🏷️ Also known as

en adapter protein en toll-interacting protein en Toll interacting protein en TOLLIP

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Toll interacting protein — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Toll interacting protein — UniProt protein ID (P352): Q9H0E2. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ Toll interacting protein — part of (P361): UBA-like superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Toll interacting protein — part of (P361): C2 domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Toll interacting protein — part of (P361): C2 domain, protein family. wikidata.org.
[7] ↑ Toll interacting protein — part of (P361): Ubiquitin system component Cue, protein family. wikidata.org.
[8] ↑ Toll interacting protein — part of (P361): Toll-interacting protein, C2 domain, protein family. wikidata.org.
[9] ↑ Toll interacting protein — has part(s) (P527): C2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Toll interacting protein — has part(s) (P527): Ubiquitin system component Cue. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Toll interacting protein — has part(s) (P527): Toll-interacting protein, C2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Toll interacting protein — RefSeq protein ID (P637): NP_001305441. Q20641742. Retrieved 2020-05-30. wikidata.org.
[13] ↑ Toll interacting protein — RefSeq protein ID (P637): NP_001305443. Q20641742. Retrieved 2020-05-30. wikidata.org.
[14] ↑ Toll interacting protein — RefSeq protein ID (P637): NP_001305444. Q20641742. Retrieved 2020-05-30. wikidata.org.
[15] ↑ Toll interacting protein — RefSeq protein ID (P637): NP_001305445. Q20641742. Retrieved 2020-05-30. wikidata.org.
[16] ↑ Toll interacting protein — RefSeq protein ID (P637): NP_061882. Q20641742. Retrieved 2020-05-30. wikidata.org.
[17] ↑ Toll interacting protein — RefSeq protein ID (P637): XP_016873420. Q20641742. Retrieved 2020-05-30. wikidata.org.
[18] ↑ Toll interacting protein — PDB structure ID (P638): 1WGL. Q905695. Retrieved 2016-03-21. wikidata.org.
[19] ↑ Toll interacting protein — PDB structure ID (P638): 2N31. Q905695. Retrieved 2016-03-21. wikidata.org.
[20] ↑ Toll interacting protein — molecular function (P680): signal transducer activity. Q24291418. Retrieved 2017-10-17. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Toll interacting protein — molecular function (P680): Toll-like receptor binding. Q24291418. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Toll interacting protein — molecular function (P680): SUMO binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Toll interacting protein — molecular function (P680): kinase binding. Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Toll interacting protein — molecular function (P680): protein binding. Recruitment of clathrin onto endosomes by the Tom1-Tollip complex. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Toll interacting protein — molecular function (P680): interleukin-1, type I receptor binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Toll interacting protein — molecular function (P680): ubiquitin protein ligase binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Toll interacting protein is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Toll interacting protein. Retrieved May 3, 2026, from https://4ort.xyz/entity/toll-interacting-protein

MLA

“Toll interacting protein.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/toll-interacting-protein.

BibTeX

@misc{4ortxyz_toll-interacting-protein_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Toll interacting protein}}, year = {2026}, url = {https://4ort.xyz/entity/toll-interacting-protein}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Toll interacting protein — https://4ort.xyz/entity/toll-interacting-protein (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/toll-interacting-protein · Last refreshed: May 3, 2026