Toll Dmel_CG5490

protein found in Drosophila melanogaster

Protein protein Q29817352

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Toll Dmel_CG5490

Summary

Toll Dmel_CG5490 is a protein^[1].

Key Facts

Toll Dmel_CG5490's instance of is recorded as protein^[2].
Toll Dmel_CG5490's UniProt protein ID is recorded as P08953^[3].
Toll Dmel_CG5490's part of is recorded as Toll/interleukin-1 receptor homology (TIR) domain superfamily^[4].
Toll Dmel_CG5490's part of is recorded as Leucine-rich repeat domain superfamily^[5].
Toll Dmel_CG5490's part of is recorded as Leucine-rich repeat N-terminal domain, protein family^[6].
Toll Dmel_CG5490's part of is recorded as Toll/interleukin-1 receptor homology (TIR) domain, protein family^[7].
Toll Dmel_CG5490's part of is recorded as Cysteine-rich flanking region, C-terminal domain, protein family^[8].
Toll Dmel_CG5490's part of is recorded as Leucine-rich repeat, typical subtype, protein family^[9].
Toll Dmel_CG5490's part of is recorded as BspA type Leucine rich repeat region, protein family^[10].
Toll Dmel_CG5490's part of is recorded as Leucine-rich repeat, protein family^[11].
Toll Dmel_CG5490's has part is recorded as BspA type Leucine rich repeat region^[12].
Toll Dmel_CG5490's has part is recorded as cysteine-rich flanking region, C-terminal^[13].
Toll Dmel_CG5490's has part is recorded as leucine-rich repeat N-terminal domain^[14].
Toll Dmel_CG5490's has part is recorded as Toll/interleukin-1 receptor homology (TIR) domain^[15].
Toll Dmel_CG5490's has part is recorded as leucine-rich repeat, typical subtype^[16].
Toll Dmel_CG5490's has part is recorded as Leucine-rich repeat^[17].
Toll Dmel_CG5490's RefSeq protein ID is recorded as NP_001262995^[18].
Toll Dmel_CG5490's RefSeq protein ID is recorded as NP_524518^[19].
Toll Dmel_CG5490's RefSeq protein ID is recorded as NP_733166^[20].
Toll Dmel_CG5490's molecular function is recorded as transmembrane signaling receptor activity^[21].
Toll Dmel_CG5490's molecular function is recorded as protein binding^[22].
Toll Dmel_CG5490's molecular function is recorded as cytokine binding^[23].
Toll Dmel_CG5490's molecular function is recorded as identical protein binding^[24].
Toll Dmel_CG5490's molecular function is recorded as TIR domain binding^[25].
Toll Dmel_CG5490's molecular function is recorded as transmembrane signaling receptor activity^[26].

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Quick Facts

Instance of protein

Part of Toll/interleukin-1 receptor homology (TIR) domain superfamily, Leucine-rich repeat domain superfamily, Leucine-rich repeat N-terminal domain, protein family, Toll/interleukin-1 receptor homology (TIR) domain, protein family, Cysteine-rich flanking region, C-terminal domain, protein family, Leucine-rich repeat, typical subtype, protein family, BspA type Leucine rich repeat region, protein family, Leucine-rich repeat, protein family

Properties

Biological process defense response to oomycetes, immune system process, defense response, immune response, positive regulation of antibacterial peptide biosynthetic process, positive regulation of antifungal peptide biosynthetic process, cell adhesion, signal transduction, multicellular organism development, zygotic specification of dorsal/ventral axis, synapse assembly, development of the heart, larval somatic muscle development, Toll signaling pathway, response to bacterium, response to fungus, embryonic pattern specification, dorsal/ventral axis specification, synaptic target inhibition, antimicrobial humoral response, antifungal humoral response, hemopoiesis, regulation of melanization defense response, hemocyte proliferation, innate immune response, regulation of hemocyte differentiation, positive regulation of transcription by RNA polymerase II, defense response to Gram-positive bacterium, defense response to fungus, regulation of embryonic pattern specification, toll-like receptor signaling pathway, positive regulation of antimicrobial peptide production, positive regulation of antifungal peptide production, inflammatory response, Toll signaling pathway, dorsal/ventral axis specification, cytokine-mediated signaling pathway, hemocyte proliferation, innate immune response, defense response to Gram-positive bacterium, antifungal innate immune response, response to wounding, dorsal/ventral axis specification, positive regulation of hemocyte proliferation, antifungal innate immune response, negative regulation of cell growth, negative regulation of multicellular organism growth, negative regulation of insulin receptor signaling pathway

Cell component cytoplasm, early endosome, plasma membrane, external side of plasma membrane, cell surface, membrane, integral component of membrane, cleavage furrow, cytoplasm, plasma membrane, integral component of plasma membrane, cell surface, protein-containing complex

Encoded by Tl

Found in taxon Drosophila melanogaster

Has part(s) BspA type Leucine rich repeat region, cysteine-rich flanking region, C-terminal, leucine-rich repeat N-terminal domain, Toll/interleukin-1 receptor homology (TIR) domain, leucine-rich repeat, typical subtype, Leucine-rich repeat

Imported from wholeness_audit_2026-05-02

Molecular function transmembrane signaling receptor activity, protein binding, cytokine binding, identical protein binding, TIR domain binding, transmembrane signaling receptor activity, cytokine receptor activity, cytokine binding

External References (3)

Ensembl protein id FBpp0303188, FBpp0303187, FBpp0084431

Refseq protein id NP_001262995, NP_524518, NP_733166

Uniprot protein id P08953

🏷️ Also known as

en CG5490 gene product from transcript CG5490-RB en CG5490-PB en CG5490-PC en CG5490-PD en EP1051 en protein toll precursor en Tl en Tl-PB en Tl-PC en Tl-PD en TOLL en Toll-1 en Toll Dmel_CG5490 en toll receptor

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Toll Dmel_CG5490 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Toll Dmel_CG5490 — UniProt protein ID (P352): P08953. Q905695. Retrieved 2022-05-25. wikidata.org.
[4] ↑ Toll Dmel_CG5490 — part of (P361): Toll/interleukin-1 receptor homology (TIR) domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Toll Dmel_CG5490 — part of (P361): Leucine-rich repeat domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Toll Dmel_CG5490 — part of (P361): Leucine-rich repeat N-terminal domain, protein family. wikidata.org.
[7] ↑ Toll Dmel_CG5490 — part of (P361): Toll/interleukin-1 receptor homology (TIR) domain, protein family. wikidata.org.
[8] ↑ Toll Dmel_CG5490 — part of (P361): Cysteine-rich flanking region, C-terminal domain, protein family. wikidata.org.
[9] ↑ Toll Dmel_CG5490 — part of (P361): Leucine-rich repeat, typical subtype, protein family. wikidata.org.
[10] ↑ Toll Dmel_CG5490 — part of (P361): BspA type Leucine rich repeat region, protein family. wikidata.org.
[11] ↑ Toll Dmel_CG5490 — part of (P361): Leucine-rich repeat, protein family. wikidata.org.
[12] ↑ Toll Dmel_CG5490 — has part(s) (P527): BspA type Leucine rich repeat region. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Toll Dmel_CG5490 — has part(s) (P527): cysteine-rich flanking region, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Toll Dmel_CG5490 — has part(s) (P527): leucine-rich repeat N-terminal domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Toll Dmel_CG5490 — has part(s) (P527): Toll/interleukin-1 receptor homology (TIR) domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Toll Dmel_CG5490 — has part(s) (P527): leucine-rich repeat, typical subtype. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Toll Dmel_CG5490 — has part(s) (P527): Leucine-rich repeat. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Toll Dmel_CG5490 — RefSeq protein ID (P637): NP_001262995. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ Toll Dmel_CG5490 — RefSeq protein ID (P637): NP_524518. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ Toll Dmel_CG5490 — RefSeq protein ID (P637): NP_733166. Q20641742. Retrieved 2022-03-20. wikidata.org.
[21] ↑ Toll Dmel_CG5490 — molecular function (P680): transmembrane signaling receptor activity. The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Toll Dmel_CG5490 — molecular function (P680): protein binding. Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Toll Dmel_CG5490 — molecular function (P680): cytokine binding. Toll gets tied in a knot. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Toll Dmel_CG5490 — molecular function (P680): identical protein binding. An extracellular interactome of immunoglobulin and LRR proteins reveals receptor-ligand networks.. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Toll Dmel_CG5490 — molecular function (P680): TIR domain binding. Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Toll Dmel_CG5490 — molecular function (P680): transmembrane signaling receptor activity. Multimerization and interaction of Toll and Spätzle in Drosophila. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Toll Dmel_CG5490 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Toll Dmel_CG5490. Retrieved May 3, 2026, from https://4ort.xyz/entity/toll-dmel-cg5490

MLA “Toll Dmel_CG5490.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/toll-dmel-cg5490.

BibTeX

@misc{4ortxyz_toll-dmel-cg5490_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Toll Dmel_CG5490}}, year = {2026}, url = {https://4ort.xyz/entity/toll-dmel-cg5490}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Toll Dmel_CG5490 — https://4ort.xyz/entity/toll-dmel-cg5490 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/toll-dmel-cg5490 · Last refreshed: May 3, 2026