TNF receptor associated factor 6

mammalian protein found in Rattus norvegicus

Protein protein Q28556432

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Summary

TNF receptor associated factor 6 is a protein^[1].

Key Facts

TNF receptor associated factor 6's instance of is recorded as protein^[2].
TNF receptor associated factor 6's subclass of is recorded as protein^[3].
TNF receptor associated factor 6's UniProt protein ID is recorded as B5DF45^[4].
TNF receptor associated factor 6's part of is recorded as TRAF-like^[5].
TNF receptor associated factor 6's part of is recorded as Zinc finger, RING/FYVE/PHD-type^[6].
TNF receptor associated factor 6's part of is recorded as TNF receptor-associated factor 6^[7].
TNF receptor associated factor 6's part of is recorded as MATH/TRAF domain, protein family^[8].
TNF receptor associated factor 6's part of is recorded as Zinc finger, RING-type, protein family^[9].
TNF receptor associated factor 6's part of is recorded as TNF receptor-associated factor 6, MATH domain, protein family^[10].
TNF receptor associated factor 6's part of is recorded as Zinc finger, TRAF-type, protein family^[11].
TNF receptor associated factor 6's part of is recorded as Zinc finger, RING-type, conserved site, protein family^[12].
TNF receptor associated factor 6's has part is recorded as Zinc finger, TRAF-type^[13].
TNF receptor associated factor 6's has part is recorded as Zinc finger, RING-type, conserved site^[14].
TNF receptor associated factor 6's has part is recorded as Zinc finger, RING-type^[15].
TNF receptor associated factor 6's has part is recorded as MATH/TRAF domain^[16].
TNF receptor associated factor 6's has part is recorded as TNF receptor-associated factor 6, MATH domain^[17].
TNF receptor associated factor 6's RefSeq protein ID is recorded as NP_001101224^[18].
TNF receptor associated factor 6's RefSeq protein ID is recorded as XP_038960852^[19].
TNF receptor associated factor 6's RefSeq protein ID is recorded as XP_038960853^[20].
TNF receptor associated factor 6's molecular function is recorded as ubiquitin-protein transferase activity^[21].
TNF receptor associated factor 6's molecular function is recorded as tumor necrosis factor receptor binding^[22].
TNF receptor associated factor 6's molecular function is recorded as zinc ion binding^[23].
TNF receptor associated factor 6's molecular function is recorded as transferase activity^[24].
TNF receptor associated factor 6's molecular function is recorded as protein kinase binding^[25].
TNF receptor associated factor 6's molecular function is recorded as mitogen-activated protein kinase kinase kinase binding^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of TRAF-like, Zinc finger, RING/FYVE/PHD-type, TNF receptor-associated factor 6, MATH/TRAF domain, protein family, Zinc finger, RING-type, protein family, TNF receptor-associated factor 6, MATH domain, protein family, Zinc finger, TRAF-type, protein family, Zinc finger, RING-type, conserved site, protein family

Properties

Biological process negative regulation of transcription by RNA polymerase II, protein polyubiquitination, ossification, neural tube closure, immune system process, positive regulation of T cell cytokine production, immune response, cellular response to DNA damage stimulus, signal transduction, I-kappaB kinase/NF-kappaB signaling, activation of NF-kappaB-inducing kinase activity, JNK cascade, animal organ morphogenesis, protein ubiquitination, cytokine-mediated signaling pathway, antigen processing and presentation of exogenous peptide antigen via MHC class II, osteoclast differentiation, positive regulation of lipopolysaccharide-mediated signaling pathway, activation of protein kinase activity, positive regulation of interleukin-2 production, T-helper 1 type immune response, positive regulation of T cell proliferation, odontogenesis of dentin-containing tooth, regulation of apoptotic process, myeloid dendritic cell differentiation, regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of JUN kinase activity, bone resorption, positive regulation of osteoclast differentiation, negative regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase II, bone remodeling, cell development, positive regulation of smooth muscle cell proliferation, T cell receptor signaling pathway, positive regulation of DNA-binding transcription factor activity, positive regulation of NF-kappaB transcription factor activity, protein autoubiquitination, interleukin-1-mediated signaling pathway, protein K63-linked ubiquitination, response to interleukin-1, cellular response to lipopolysaccharide, cellular response to cytokine stimulus, positive regulation of NIK/NF-kappaB signaling, positive regulation of leukocyte adhesion to vascular endothelial cell, positive regulation of transcription regulatory region DNA binding

Cell component nucleus, cytoplasm, lipid droplet, cytosol, plasma membrane, cell cortex, cytoplasmic side of plasma membrane, protein-containing complex, CD40 receptor complex, perinuclear region of cytoplasm

Encoded by Traf6

Found in taxon brown rat

Has part(s) Zinc finger, TRAF-type, Zinc finger, RING-type, conserved site, Zinc finger, RING-type, MATH/TRAF domain, TNF receptor-associated factor 6, MATH domain

Imported from wholeness_audit_2026-05-02

Molecular function ubiquitin-protein transferase activity, tumor necrosis factor receptor binding, zinc ion binding, transferase activity, protein kinase binding, mitogen-activated protein kinase kinase kinase binding, ubiquitin conjugating enzyme binding, ubiquitin protein ligase binding, thioesterase binding, identical protein binding, histone deacetylase binding, protein kinase B binding, metal ion binding, protein N-terminus binding, ubiquitin protein ligase activity

External References (3)

Ensembl protein id ENSRNOP00000006148, ENSRNOP00000086655

Refseq protein id NP_001101224, XP_038960852, XP_038960853

Uniprot protein id B5DF45

🏷️ Also known as

en E3 ubiquitin-protein ligase TRAF6 en RING-type E3 ubiquitin transferase TRAF6 en TNF receptor associated factor 6 en TNF receptor-associated factor 6 en TNF receptor-associated factor 6, E3 ubiquitin protein ligase en Traf6

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ TNF receptor associated factor 6 — instance of (P31): protein. UniProt. Retrieved 2022-05-25. wikidata.org.
[3] ↑ TNF receptor associated factor 6 — subclass of (P279): protein. UniProt. Retrieved 2017-01-19. wikidata.org.
[4] ↑ TNF receptor associated factor 6 — UniProt protein ID (P352): B5DF45. UniProt. Retrieved 2022-05-25. wikidata.org.
[5] ↑ TNF receptor associated factor 6 — part of (P361): TRAF-like. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ TNF receptor associated factor 6 — part of (P361): Zinc finger, RING/FYVE/PHD-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ TNF receptor associated factor 6 — part of (P361): TNF receptor-associated factor 6. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ TNF receptor associated factor 6 — part of (P361): MATH/TRAF domain, protein family. wikidata.org.
[9] ↑ TNF receptor associated factor 6 — part of (P361): Zinc finger, RING-type, protein family. wikidata.org.
[10] ↑ TNF receptor associated factor 6 — part of (P361): TNF receptor-associated factor 6, MATH domain, protein family. wikidata.org.
[11] ↑ TNF receptor associated factor 6 — part of (P361): Zinc finger, TRAF-type, protein family. wikidata.org.
[12] ↑ TNF receptor associated factor 6 — part of (P361): Zinc finger, RING-type, conserved site, protein family. wikidata.org.
[13] ↑ TNF receptor associated factor 6 — has part(s) (P527): Zinc finger, TRAF-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ TNF receptor associated factor 6 — has part(s) (P527): Zinc finger, RING-type, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ TNF receptor associated factor 6 — has part(s) (P527): Zinc finger, RING-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ TNF receptor associated factor 6 — has part(s) (P527): MATH/TRAF domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ TNF receptor associated factor 6 — has part(s) (P527): TNF receptor-associated factor 6, MATH domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ TNF receptor associated factor 6 — RefSeq protein ID (P637): NP_001101224. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ TNF receptor associated factor 6 — RefSeq protein ID (P637): XP_038960852. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ TNF receptor associated factor 6 — RefSeq protein ID (P637): XP_038960853. Q20641742. Retrieved 2022-03-20. wikidata.org.
[21] ↑ TNF receptor associated factor 6 — molecular function (P680): ubiquitin-protein transferase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ TNF receptor associated factor 6 — molecular function (P680): tumor necrosis factor receptor binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ TNF receptor associated factor 6 — molecular function (P680): zinc ion binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ TNF receptor associated factor 6 — molecular function (P680): transferase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ TNF receptor associated factor 6 — molecular function (P680): protein kinase binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ TNF receptor associated factor 6 — molecular function (P680): mitogen-activated protein kinase kinase kinase binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ TNF receptor associated factor 6 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). TNF receptor associated factor 6. Retrieved May 3, 2026, from https://4ort.xyz/entity/tnf-receptor-associated-factor-6-q28556432

MLA

“TNF receptor associated factor 6.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/tnf-receptor-associated-factor-6-q28556432.

BibTeX

@misc{4ortxyz_tnf-receptor-associated-factor-6-q28556432_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{TNF receptor associated factor 6}}, year = {2026}, url = {https://4ort.xyz/entity/tnf-receptor-associated-factor-6-q28556432}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): TNF receptor associated factor 6 — https://4ort.xyz/entity/tnf-receptor-associated-factor-6-q28556432 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/tnf-receptor-associated-factor-6-q28556432 · Last refreshed: May 3, 2026