TNF receptor-associated factor 6

mammalian protein found in Mus musculus

Protein protein Q21497539

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Summary

TNF receptor-associated factor 6 is a protein^[1].

Key Facts

TNF receptor-associated factor 6's instance of is recorded as protein^[2].
TNF receptor-associated factor 6's subclass of is recorded as protein^[3].
TNF receptor-associated factor 6's UniProt protein ID is recorded as P70196^[4].
TNF receptor-associated factor 6's part of is recorded as TRAF-like^[5].
TNF receptor-associated factor 6's part of is recorded as Zinc finger, RING/FYVE/PHD-type^[6].
TNF receptor-associated factor 6's part of is recorded as TNF receptor-associated factor 6^[7].
TNF receptor-associated factor 6's part of is recorded as MATH/TRAF domain, protein family^[8].
TNF receptor-associated factor 6's part of is recorded as Zinc finger, RING-type, protein family^[9].
TNF receptor-associated factor 6's part of is recorded as TNF receptor-associated factor 6, MATH domain, protein family^[10].
TNF receptor-associated factor 6's part of is recorded as Zinc finger, TRAF-type, protein family^[11].
TNF receptor-associated factor 6's part of is recorded as Zinc finger, RING-type, conserved site, protein family^[12].
TNF receptor-associated factor 6's has part is recorded as Zinc finger, TRAF-type^[13].
TNF receptor-associated factor 6's has part is recorded as Zinc finger, RING-type, conserved site^[14].
TNF receptor-associated factor 6's has part is recorded as Zinc finger, RING-type^[15].
TNF receptor-associated factor 6's has part is recorded as MATH/TRAF domain^[16].
TNF receptor-associated factor 6's has part is recorded as TNF receptor-associated factor 6, MATH domain^[17].
TNF receptor-associated factor 6's RefSeq protein ID is recorded as NP_001290202^[18].
TNF receptor-associated factor 6's RefSeq protein ID is recorded as NP_033450^[19].
TNF receptor-associated factor 6's molecular function is recorded as ubiquitin protein ligase activity^[20].
TNF receptor-associated factor 6's molecular function is recorded as protein N-terminus binding^[21].
TNF receptor-associated factor 6's molecular function is recorded as mitogen-activated protein kinase kinase kinase binding^[22].
TNF receptor-associated factor 6's molecular function is recorded as zinc ion binding^[23].
TNF receptor-associated factor 6's molecular function is recorded as histone deacetylase binding^[24].
TNF receptor-associated factor 6's molecular function is recorded as signal transducer activity^[25].
TNF receptor-associated factor 6's molecular function is recorded as protein kinase B binding^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of TRAF-like, Zinc finger, RING/FYVE/PHD-type, TNF receptor-associated factor 6, MATH/TRAF domain, protein family, Zinc finger, RING-type, protein family, TNF receptor-associated factor 6, MATH domain, protein family, Zinc finger, TRAF-type, protein family, Zinc finger, RING-type, conserved site, protein family

Properties

Biological process regulation of apoptotic process, positive regulation of transcription regulatory region DNA binding, response to interleukin-1, antigen processing and presentation of exogenous peptide antigen via MHC class II, cell development, ossification, immune system process, positive regulation of JUN kinase activity, osteoclast differentiation, protein K63-linked ubiquitination, positive regulation of DNA-binding transcription factor activity, protein polyubiquitination, activation of NF-kappaB-inducing kinase activity, negative regulation of transcription by RNA polymerase II, myeloid dendritic cell differentiation, positive regulation of osteoclast differentiation, bone resorption, positive regulation of lipopolysaccharide-mediated signaling pathway, odontogenesis of dentin-containing tooth, neural tube closure, bone remodeling, positive regulation of interleukin-2 production, positive regulation of NF-kappaB transcription factor activity, positive regulation of T cell cytokine production, protein ubiquitination, positive regulation of T cell proliferation, animal organ morphogenesis, T-helper 1 type immune response, positive regulation of I-kappaB kinase/NF-kappaB signaling, negative regulation of transcription, DNA-templated, I-kappaB kinase/NF-kappaB signaling, T cell receptor signaling pathway, cellular response to lipopolysaccharide, activation of protein kinase activity, signal transduction, positive regulation of transcription by RNA polymerase II, protein autoubiquitination, cellular response to DNA damage stimulus, immune response, regulation of I-kappaB kinase/NF-kappaB signaling, JNK cascade, cytokine-mediated signaling pathway, positive regulation of smooth muscle cell proliferation, protein-containing complex assembly, interleukin-1-mediated signaling pathway, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of NF-kappaB transcription factor activity, interleukin-1-mediated signaling pathway, protein K63-linked ubiquitination, cellular response to cytokine stimulus, positive regulation of NIK/NF-kappaB signaling, positive regulation of leukocyte adhesion to vascular endothelial cell, cellular response to cytokine stimulus, positive regulation of NIK/NF-kappaB signaling, positive regulation of leukocyte adhesion to vascular endothelial cell

Cell component cytoplasm, cytosol, lipid droplet, plasma membrane, cell cortex, perinuclear region of cytoplasm, CD40 receptor complex, cytoplasmic side of plasma membrane, nucleus, protein-containing complex, protein-containing complex

Encoded by Traf6

Found in taxon house mouse

Has part(s) Zinc finger, TRAF-type, Zinc finger, RING-type, conserved site, Zinc finger, RING-type, MATH/TRAF domain, TNF receptor-associated factor 6, MATH domain

Imported from wholeness_audit_2026-05-02

Molecular function ubiquitin protein ligase activity, protein N-terminus binding, mitogen-activated protein kinase kinase kinase binding, zinc ion binding, histone deacetylase binding, signal transducer activity, protein kinase B binding, metal ion binding, ubiquitin-protein transferase activity, protein binding, identical protein binding, thioesterase binding, tumor necrosis factor receptor binding, ubiquitin conjugating enzyme binding, protein kinase binding, ubiquitin protein ligase binding, transferase activity, ubiquitin-protein transferase activity, tumor necrosis factor receptor binding

External References (3)

Ensembl protein id ENSMUSP00000004949

Refseq protein id NP_001290202, NP_033450

Uniprot protein id P70196

🏷️ Also known as

en E3 ubiquitin-protein ligase TRAF6 en RING-type E3 ubiquitin transferase TRAF6 en TNF receptor-associated factor 6 en Traf6

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ TNF receptor-associated factor 6 — instance of (P31): protein. UniProt. Retrieved 2022-05-25. wikidata.org.
[3] ↑ TNF receptor-associated factor 6 — subclass of (P279): protein. UniProt. Retrieved 2017-01-19. wikidata.org.
[4] ↑ TNF receptor-associated factor 6 — UniProt protein ID (P352): P70196. UniProt. Retrieved 2022-05-25. wikidata.org.
[5] ↑ TNF receptor-associated factor 6 — part of (P361): TRAF-like. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ TNF receptor-associated factor 6 — part of (P361): Zinc finger, RING/FYVE/PHD-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ TNF receptor-associated factor 6 — part of (P361): TNF receptor-associated factor 6. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ TNF receptor-associated factor 6 — part of (P361): MATH/TRAF domain, protein family. wikidata.org.
[9] ↑ TNF receptor-associated factor 6 — part of (P361): Zinc finger, RING-type, protein family. wikidata.org.
[10] ↑ TNF receptor-associated factor 6 — part of (P361): TNF receptor-associated factor 6, MATH domain, protein family. wikidata.org.
[11] ↑ TNF receptor-associated factor 6 — part of (P361): Zinc finger, TRAF-type, protein family. wikidata.org.
[12] ↑ TNF receptor-associated factor 6 — part of (P361): Zinc finger, RING-type, conserved site, protein family. wikidata.org.
[13] ↑ TNF receptor-associated factor 6 — has part(s) (P527): Zinc finger, TRAF-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ TNF receptor-associated factor 6 — has part(s) (P527): Zinc finger, RING-type, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ TNF receptor-associated factor 6 — has part(s) (P527): Zinc finger, RING-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ TNF receptor-associated factor 6 — has part(s) (P527): MATH/TRAF domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ TNF receptor-associated factor 6 — has part(s) (P527): TNF receptor-associated factor 6, MATH domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ TNF receptor-associated factor 6 — RefSeq protein ID (P637): NP_001290202. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ TNF receptor-associated factor 6 — RefSeq protein ID (P637): NP_033450. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ TNF receptor-associated factor 6 — molecular function (P680): ubiquitin protein ligase activity. Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ TNF receptor-associated factor 6 — molecular function (P680): protein N-terminus binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ TNF receptor-associated factor 6 — molecular function (P680): mitogen-activated protein kinase kinase kinase binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ TNF receptor-associated factor 6 — molecular function (P680): zinc ion binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ TNF receptor-associated factor 6 — molecular function (P680): histone deacetylase binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ TNF receptor-associated factor 6 — molecular function (P680): signal transducer activity. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ TNF receptor-associated factor 6 — molecular function (P680): protein kinase B binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ TNF receptor-associated factor 6 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

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BibTeX

@misc{4ortxyz_tnf-receptor-associated-factor-6-q21497539_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{TNF receptor-associated factor 6}}, year = {2026}, url = {https://4ort.xyz/entity/tnf-receptor-associated-factor-6-q21497539}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): TNF receptor-associated factor 6 — https://4ort.xyz/entity/tnf-receptor-associated-factor-6-q21497539 (retrieved 2026-05-03)

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