TNF receptor-associated factor 2

mammalian protein found in Mus musculus

Protein protein Q14914363

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Summary

TNF receptor-associated factor 2 is a protein^[1].

Key Facts

TNF receptor-associated factor 2's instance of is recorded as protein^[2].
TNF receptor-associated factor 2's subclass of is recorded as protein^[3].
TNF receptor-associated factor 2's UniProt protein ID is recorded as P39429^[4].
TNF receptor-associated factor 2's part of is recorded as TRAF-like^[5].
TNF receptor-associated factor 2's part of is recorded as Zinc finger, RING/FYVE/PHD-type^[6].
TNF receptor-associated factor 2's part of is recorded as TNF receptor-associated factor 2^[7].
TNF receptor-associated factor 2's part of is recorded as MATH/TRAF domain, protein family^[8].
TNF receptor-associated factor 2's part of is recorded as TNF receptor-associated factor 2, MATH domain, protein family^[9].
TNF receptor-associated factor 2's part of is recorded as Zinc finger, RING-type, protein family^[10].
TNF receptor-associated factor 2's part of is recorded as Zinc finger, C3HC4 RING-type, protein family^[11].
TNF receptor-associated factor 2's part of is recorded as TNF receptor-associated factor, BIRC3 binding domain, protein family^[12].
TNF receptor-associated factor 2's part of is recorded as Zinc finger, TRAF-type, protein family^[13].
TNF receptor-associated factor 2's part of is recorded as Zinc finger, RING-type, conserved site, protein family^[14].
TNF receptor-associated factor 2's has part is recorded as Zinc finger, TRAF-type^[15].
TNF receptor-associated factor 2's has part is recorded as Zinc finger, RING-type, conserved site^[16].
TNF receptor-associated factor 2's has part is recorded as Zinc finger, RING-type^[17].
TNF receptor-associated factor 2's has part is recorded as Zinc finger, C3HC4 RING-type^[18].
TNF receptor-associated factor 2's has part is recorded as TNF receptor-associated factor, BIRC3 binding domain^[19].
TNF receptor-associated factor 2's has part is recorded as MATH/TRAF domain^[20].
TNF receptor-associated factor 2's has part is recorded as TNF receptor-associated factor 2, MATH domain^[21].
TNF receptor-associated factor 2's RefSeq protein ID is recorded as NP_001277342^[22].
TNF receptor-associated factor 2's RefSeq protein ID is recorded as NP_033448^[23].
TNF receptor-associated factor 2's RefSeq protein ID is recorded as XP_006497912^[24].
TNF receptor-associated factor 2's RefSeq protein ID is recorded as XP_006497913^[25].
TNF receptor-associated factor 2's molecular function is recorded as sphingolipid binding^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of TRAF-like, Zinc finger, RING/FYVE/PHD-type, TNF receptor-associated factor 2, MATH/TRAF domain, protein family, TNF receptor-associated factor 2, MATH domain, protein family, Zinc finger, RING-type, protein family, Zinc finger, C3HC4 RING-type, protein family, TNF receptor-associated factor, BIRC3 binding domain, protein family, Zinc finger, TRAF-type, protein family, Zinc finger, RING-type, conserved site, protein family

Properties

Biological process regulation of apoptotic process, positive regulation of tumor necrosis factor-mediated signaling pathway, positive regulation of JUN kinase activity, protein K63-linked ubiquitination, positive regulation of DNA-binding transcription factor activity, negative regulation of apoptotic process, tumor necrosis factor-mediated signaling pathway, activation of NF-kappaB-inducing kinase activity, positive regulation of protein homodimerization activity, protein homotrimerization, regulation of JNK cascade, positive regulation of I-kappaB phosphorylation, protein catabolic process, positive regulation of NF-kappaB transcription factor activity, positive regulation of interleukin-2 production, positive regulation of T cell cytokine production, protein ubiquitination, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of extrinsic apoptotic signaling pathway, cellular response to nitric oxide, programmed necrotic cell death, signal transduction, protein autoubiquitination, apoptotic process, negative regulation of glial cell apoptotic process, protein heterooligomerization, protein-containing complex assembly, tumor necrosis factor-mediated signaling pathway, positive regulation of NF-kappaB transcription factor activity

Cell component TRAF2-GSTP1 complex, AIP1-IRE1 complex, ubiquitin ligase complex, vesicle membrane, CD40 receptor complex, cytoplasmic side of plasma membrane, IRE1-TRAF2-ASK1 complex, cytosol, cytoplasm, cell cortex, protein-containing complex, membrane raft, cytosol, protein-containing complex, membrane raft, IRE1-TRAF2-ASK1 complex

Encoded by Traf2

Found in taxon house mouse

Has part(s) Zinc finger, TRAF-type, Zinc finger, RING-type, conserved site, Zinc finger, RING-type, Zinc finger, C3HC4 RING-type, TNF receptor-associated factor, BIRC3 binding domain, MATH/TRAF domain, TNF receptor-associated factor 2, MATH domain

Imported from wholeness_audit_2026-05-02

Molecular function sphingolipid binding, CD40 receptor binding, zinc ion binding, metal ion binding, ubiquitin-protein transferase activity, protein binding, identical protein binding, thioesterase binding, enzyme binding, tumor necrosis factor receptor binding, protein phosphatase binding, protein kinase binding, ubiquitin protein ligase binding, lipid binding, transferase activity, signaling receptor binding, mitogen-activated protein kinase kinase kinase binding, protein-containing complex binding, thioesterase binding, tumor necrosis factor receptor binding, protein kinase binding, protein-containing complex binding

External References (3)

Ensembl protein id ENSMUSP00000028311, ENSMUSP00000109872

Refseq protein id NP_001277342, NP_033448, XP_006497912, XP_006497913

Uniprot protein id P39429

🏷️ Also known as

en E3 ubiquitin-protein ligase TRAF2 en RING-type E3 ubiquitin transferase TRAF2 en TNF receptor-associated factor 2 en Traf2

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ TNF receptor-associated factor 2 — instance of (P31): protein. UniProt. Retrieved 2022-05-25. wikidata.org.
[3] ↑ TNF receptor-associated factor 2 — subclass of (P279): protein. UniProt. Retrieved 2017-01-19. wikidata.org.
[4] ↑ TNF receptor-associated factor 2 — UniProt protein ID (P352): P39429. UniProt. Retrieved 2022-05-25. wikidata.org.
[5] ↑ TNF receptor-associated factor 2 — part of (P361): TRAF-like. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ TNF receptor-associated factor 2 — part of (P361): Zinc finger, RING/FYVE/PHD-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ TNF receptor-associated factor 2 — part of (P361): TNF receptor-associated factor 2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ TNF receptor-associated factor 2 — part of (P361): MATH/TRAF domain, protein family. wikidata.org.
[9] ↑ TNF receptor-associated factor 2 — part of (P361): TNF receptor-associated factor 2, MATH domain, protein family. wikidata.org.
[10] ↑ TNF receptor-associated factor 2 — part of (P361): Zinc finger, RING-type, protein family. wikidata.org.
[11] ↑ TNF receptor-associated factor 2 — part of (P361): Zinc finger, C3HC4 RING-type, protein family. wikidata.org.
[12] ↑ TNF receptor-associated factor 2 — part of (P361): TNF receptor-associated factor, BIRC3 binding domain, protein family. wikidata.org.
[13] ↑ TNF receptor-associated factor 2 — part of (P361): Zinc finger, TRAF-type, protein family. wikidata.org.
[14] ↑ TNF receptor-associated factor 2 — part of (P361): Zinc finger, RING-type, conserved site, protein family. wikidata.org.
[15] ↑ TNF receptor-associated factor 2 — has part(s) (P527): Zinc finger, TRAF-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ TNF receptor-associated factor 2 — has part(s) (P527): Zinc finger, RING-type, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ TNF receptor-associated factor 2 — has part(s) (P527): Zinc finger, RING-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ TNF receptor-associated factor 2 — has part(s) (P527): Zinc finger, C3HC4 RING-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ TNF receptor-associated factor 2 — has part(s) (P527): TNF receptor-associated factor, BIRC3 binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ TNF receptor-associated factor 2 — has part(s) (P527): MATH/TRAF domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ TNF receptor-associated factor 2 — has part(s) (P527): TNF receptor-associated factor 2, MATH domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ TNF receptor-associated factor 2 — RefSeq protein ID (P637): NP_001277342. Q20641742. Retrieved 2022-03-20. wikidata.org.
[23] ↑ TNF receptor-associated factor 2 — RefSeq protein ID (P637): NP_033448. Q20641742. Retrieved 2022-03-20. wikidata.org.
[24] ↑ TNF receptor-associated factor 2 — RefSeq protein ID (P637): XP_006497912. Q20641742. Retrieved 2022-03-20. wikidata.org.
[25] ↑ TNF receptor-associated factor 2 — RefSeq protein ID (P637): XP_006497913. Q20641742. Retrieved 2022-03-20. wikidata.org.
[26] ↑ TNF receptor-associated factor 2 — molecular function (P680): sphingolipid binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ TNF receptor-associated factor 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). TNF receptor-associated factor 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/tnf-receptor-associated-factor-2-q14914363

MLA

“TNF receptor-associated factor 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/tnf-receptor-associated-factor-2-q14914363.

BibTeX

@misc{4ortxyz_tnf-receptor-associated-factor-2-q14914363_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{TNF receptor-associated factor 2}}, year = {2026}, url = {https://4ort.xyz/entity/tnf-receptor-associated-factor-2-q14914363}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): TNF receptor-associated factor 2 — https://4ort.xyz/entity/tnf-receptor-associated-factor-2-q14914363 (retrieved 2026-05-03)

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