TNF receptor associated factor 2

mammalian protein found in Homo sapiens

Protein protein Q7671245

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TNF receptor associated factor 2

Summary

TNF receptor associated factor 2 is a protein^[1]. It is known by 7 alternative names across languages and contexts.^[2]

Key Facts

TNF receptor associated factor 2's instance of is recorded as protein^[3].
TNF receptor associated factor 2 is part of TRAF-like^[4].
TNF receptor associated factor 2 is part of Zinc finger, RING/FYVE/PHD-type^[5].
TNF receptor associated factor 2 is part of TNF receptor-associated factor 2^[6].
TNF receptor associated factor 2 is part of MATH/TRAF domain, protein family^[7].
TNF receptor associated factor 2 is part of TNF receptor-associated factor 2, MATH domain, protein family^[8].
TNF receptor associated factor 2 is part of Zinc finger, RING-type, protein family^[9].
TNF receptor associated factor 2 is part of Zinc finger, C3HC4 RING-type, protein family^[10].
TNF receptor associated factor 2 is part of TNF receptor-associated factor, BIRC3 binding domain, protein family^[11].
TNF receptor associated factor 2 is part of Zinc finger, TRAF-type, protein family^[12].
TNF receptor associated factor 2 is part of Zinc finger, RING-type, conserved site, protein family^[13].
TNF receptor associated factor 2 comprises Zinc finger, RING-type, conserved site^[14].
TNF receptor associated factor 2 comprises Zinc finger, TRAF-type^[15].
TNF receptor associated factor 2 comprises Zinc finger, C3HC4 RING-type^[16].
TNF receptor associated factor 2 comprises Zinc finger, RING-type^[17].
TNF receptor associated factor 2 comprises TNF receptor-associated factor, BIRC3 binding domain^[18].
TNF receptor associated factor 2 comprises MATH/TRAF domain^[19].
TNF receptor associated factor 2 comprises TNF receptor-associated factor 2, MATH domain^[20].
TNF receptor associated factor 2's molecular function is recorded as sphingolipid binding^[21].
TNF receptor associated factor 2's molecular function is recorded as lipid binding^[22].
TNF receptor associated factor 2's molecular function is recorded as CD40 receptor binding^[23].
TNF receptor associated factor 2's molecular function is recorded as mitogen-activated protein kinase kinase kinase binding^[24].
TNF receptor associated factor 2's molecular function is recorded as zinc ion binding^[25].
TNF receptor associated factor 2's molecular function is recorded as signal transducer activity^[26].
TNF receptor associated factor 2's molecular function is recorded as metal ion binding^[27].

Why It Matters

TNF receptor associated factor 2 is known by 7 alternative names across languages and contexts.^[2]

⭐ Popularity Graph

1/100 established

Quick Facts

Instance of protein

Part of TRAF-like, Zinc finger, RING/FYVE/PHD-type, TNF receptor-associated factor 2, MATH/TRAF domain, protein family, TNF receptor-associated factor 2, MATH domain, protein family, Zinc finger, RING-type, protein family, Zinc finger, C3HC4 RING-type, protein family, TNF receptor-associated factor, BIRC3 binding domain, protein family, Zinc finger, TRAF-type, protein family, Zinc finger, RING-type, conserved site, protein family

Properties

Biological process regulation of apoptotic process, positive regulation of tumor necrosis factor-mediated signaling pathway, positive regulation of JUN kinase activity, negative regulation of glial cell apoptotic process, regulation of tumor necrosis factor-mediated signaling pathway, protein K63-linked ubiquitination, positive regulation of DNA-binding transcription factor activity, tumor necrosis factor-mediated signaling pathway, activation of NF-kappaB-inducing kinase activity, positive regulation of protein homodimerization activity, response to endoplasmic reticulum stress, protein homotrimerization, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, positive regulation of I-kappaB phosphorylation, regulation of JNK cascade, protein catabolic process, positive regulation of NF-kappaB transcription factor activity, positive regulation of interleukin-2 production, death-inducing signaling complex assembly, positive regulation of T cell cytokine production, protein ubiquitination, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of extrinsic apoptotic signaling pathway, cellular response to nitric oxide, regulation of extrinsic apoptotic signaling pathway via death domain receptors, I-kappaB kinase/NF-kappaB signaling, activation of cysteine-type endopeptidase activity involved in apoptotic process, signal transduction, protein autoubiquitination, negative regulation of neuron death, programmed necrotic cell death, apoptotic process, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, protein deubiquitination, protein heterooligomerization, protein-containing complex assembly, tumor necrosis factor-mediated signaling pathway, positive regulation of NF-kappaB transcription factor activity

Cell component TRAF2-GSTP1 complex, AIP1-IRE1 complex, ubiquitin ligase complex, vesicle membrane, cell cortex, membrane raft, CD40 receptor complex, cytoplasmic side of plasma membrane, IRE1-TRAF2-ASK1 complex, nucleoplasm, cytoplasm, cytosol, protein-containing complex, cytosol, protein-containing complex, membrane raft, IRE1-TRAF2-ASK1 complex

Ec enzyme number 2.3.2.27

Encoded by TRAF2

Found in taxon Homo sapiens

Has part(s) Zinc finger, RING-type, conserved site, Zinc finger, TRAF-type, Zinc finger, C3HC4 RING-type, Zinc finger, RING-type, TNF receptor-associated factor, BIRC3 binding domain, MATH/TRAF domain, TNF receptor-associated factor 2, MATH domain

Molecular function sphingolipid binding, lipid binding, CD40 receptor binding, mitogen-activated protein kinase kinase kinase binding, zinc ion binding, signal transducer activity, metal ion binding, ubiquitin-protein transferase activity, protein binding, identical protein binding, thioesterase binding, enzyme binding, protein phosphatase binding, protein kinase binding, ubiquitin protein ligase binding, transferase activity, tumor necrosis factor receptor binding, protein-containing complex binding, thioesterase binding, tumor necrosis factor receptor binding, protein kinase binding

External References (4)

Ensembl protein id ENSP00000247668, ENSP00000397653, ENSP00000405860, ENSP00000406524

Pdb structure id 3M0D, 1CA4, 1CA9, 1CZY, 1CZZ, 1D00, 1D01, 1D0A, 1D0J, 1F3V, 1QSC, 3KNV, 3M06, 3M0A

Refseq protein id NP_066961, XP_011517276, XP_011517278, XP_011517279

Uniprot protein id Ilocos Region

🏷️ Also known as

en E3 ubiquitin-protein ligase TRAF2 en RING-type E3 ubiquitin transferase TRAF2 en TNF receptor associated factor 2 en TNF receptor-associated factor 2 en TRAF2 en tumor necrosis factor type 2 receptor associated protein 3 en Tumor necrosis factor type 2 receptor-associated protein 3

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). TNF receptor associated factor 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/tnf-receptor-associated-factor-2

MLA

“TNF receptor associated factor 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/tnf-receptor-associated-factor-2.

BibTeX

@misc{4ortxyz_tnf-receptor-associated-factor-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{TNF receptor associated factor 2}}, year = {2026}, url = {https://4ort.xyz/entity/tnf-receptor-associated-factor-2}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): TNF receptor associated factor 2 — https://4ort.xyz/entity/tnf-receptor-associated-factor-2 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/tnf-receptor-associated-factor-2 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

7w ago · Boghog · 2026-07-23 view diff on Wikidata ↗

Uniprot protein id → Ilocos Region

Ec enzyme number → 2.3.2.27

Refseq protein id → NP_066961, XP_011517276, XP_011517278 +1

Imported from → —

+ 12 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.3.2.27, [[:toollabs:quickstatements/#/batch/261457|batch #261457]]"

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TNF receptor associated factor 2

TNF receptor associated factor 2

Summary

Key Facts

Why It Matters

References

Direct Wikidata claims

Class ancestry

Aggregate / graph-position facts

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