TNF alpha induced protein 3

mammalian protein found in Homo sapiens

Protein protein Q21109230

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TNF alpha induced protein 3

Summary

TNF alpha induced protein 3 is a protein^[1].

Key Facts

TNF alpha induced protein 3's instance of is recorded as protein^[2].
TNF alpha induced protein 3's UniProt protein ID is recorded as P21580^[3].
TNF alpha induced protein 3's part of is recorded as A20 peptidase^[4].
TNF alpha induced protein 3's part of is recorded as OTU domain, protein family^[5].
TNF alpha induced protein 3's part of is recorded as Zinc finger, A20-type, protein family^[6].
TNF alpha induced protein 3's MeSH descriptor ID is recorded as C076529^[7].
TNF alpha induced protein 3's has part is recorded as Zinc finger, A20-type^[8].
TNF alpha induced protein 3's has part is recorded as OTU domain^[9].
TNF alpha induced protein 3's RefSeq protein ID is recorded as NP_001257436^[10].
TNF alpha induced protein 3's RefSeq protein ID is recorded as NP_001257437^[11].
TNF alpha induced protein 3's RefSeq protein ID is recorded as NP_006281^[12].
TNF alpha induced protein 3's RefSeq protein ID is recorded as XP_005267176^[13].
TNF alpha induced protein 3's RefSeq protein ID is recorded as XP_006715618^[14].
TNF alpha induced protein 3's RefSeq protein ID is recorded as XP_011534397^[15].
TNF alpha induced protein 3's RefSeq protein ID is recorded as XP_011534398^[16].
TNF alpha induced protein 3's RefSeq protein ID is recorded as XP_024302300^[17].
TNF alpha induced protein 3's RefSeq protein ID is recorded as XP_024302301^[18].
TNF alpha induced protein 3's PDB structure ID is recorded as 2EQF^[19].
TNF alpha induced protein 3's PDB structure ID is recorded as 2EQG^[20].
TNF alpha induced protein 3's PDB structure ID is recorded as 2VFJ^[21].
TNF alpha induced protein 3's PDB structure ID is recorded as 3DKB^[22].
TNF alpha induced protein 3's PDB structure ID is recorded as 3OJ3^[23].
TNF alpha induced protein 3's PDB structure ID is recorded as 3OJ4^[24].
TNF alpha induced protein 3's PDB structure ID is recorded as 3VUW^[25].
TNF alpha induced protein 3's PDB structure ID is recorded as 3VUX^[26].

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Quick Facts

Instance of protein

Part of A20 peptidase, OTU domain, protein family, Zinc finger, A20-type, protein family

Properties

Biological process regulation of germinal center formation, positive regulation of hepatocyte proliferation, negative regulation of endothelial cell apoptotic process, negative regulation of interleukin-1 beta production, negative regulation of smooth muscle cell proliferation, regulation of vascular wound healing, B-1 B cell homeostasis, protein K48-linked deubiquitination, positive regulation of protein catabolic process, negative regulation of cyclin-dependent protein serine/threonine kinase activity, regulation of defense response to virus by host, protein deubiquitination involved in ubiquitin-dependent protein catabolic process, negative regulation of toll-like receptor 2 signaling pathway, negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway, regulation of tumor necrosis factor-mediated signaling pathway, negative regulation of interleukin-6 production, negative regulation of B cell activation, negative regulation of toll-like receptor 5 signaling pathway, tolerance induction to lipopolysaccharide, response to muramyl dipeptide, negative regulation of chronic inflammatory response, negative regulation of cell death, negative regulation of I-kappaB kinase/NF-kappaB signaling, proteolysis, establishment of protein localization to vacuole, protein deubiquitination, negative regulation of protein ubiquitination, protein K48-linked ubiquitination, protein K63-linked deubiquitination, negative regulation of CD40 signaling pathway, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, protein complex oligomerization, protein K11-linked deubiquitination, regulation of inflammatory response, negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway, negative regulation of innate immune response, negative regulation of osteoclast proliferation, negative regulation of tumor necrosis factor production, negative regulation of type I interferon production, metabolism, inflammatory response, response to molecule of bacterial origin, negative regulation of NF-kappaB transcription factor activity, negative regulation of interleukin-2 production, negative regulation of inflammatory response, negative regulation of toll-like receptor 3 signaling pathway, nucleotide-binding oligomerization domain containing signaling pathway, cellular response to lipopolysaccharide, negative regulation of toll-like receptor 4 signaling pathway, negative regulation of bone resorption, cellular response to hydrogen peroxide, apoptotic process, protein ubiquitination, cytoskeleton organization, cell migration, positive regulation of Wnt signaling pathway, protein K29-linked deubiquitination, protein K33-linked deubiquitination

Cell component cytoplasm, cytosol, lysosome, extracellular exosome, nucleus, nucleus, intracellular membrane-bounded organelle, extracellular exosome

Encoded by TNFAIP3

Found in taxon Homo sapiens

Has part(s) Zinc finger, A20-type, OTU domain

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, cysteine-type peptidase activity, zinc ion binding, metal ion binding, ubiquitin-protein transferase activity, protease binding, protein self-association, peptidase activity, ligase activity, kinase binding, K63-linked polyubiquitin modification-dependent protein binding, ubiquitin binding, protein binding, catalytic activity, thiol-dependent deubiquitinase, hydrolase activity, identical protein binding, Lys63-specific deubiquitinase activity, thiol-dependent deubiquitinase, thiol-dependent deubiquitinase, transferase activity

External References (6)

Ensembl protein id ENSP00000237289, ENSP00000481570, ENSP00000393577, ENSP00000401562, ENSP00000409845, ENSP00000478438, ENSP00000479556, ENSP00000481122, ENSP00000481454, ENSP00000484332

Mesh descriptor id C076529

Pdb structure id 2EQF, 2EQG, 2VFJ, 3DKB, 3OJ3, 3OJ4, 3VUW, 3VUX, 3VUY, 3ZJD, 3ZJE, 3ZJF, 3ZJG, 4ZRH, 4ZS5

Refseq protein id NP_001257436, NP_001257437, NP_006281, XP_005267176, XP_006715618, XP_011534397, XP_011534398, XP_024302300, XP_024302301

Umls cui C0171965

Uniprot protein id P21580

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ TNF alpha induced protein 3 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ TNF alpha induced protein 3 — UniProt protein ID (P352): P21580. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ TNF alpha induced protein 3 — part of (P361): A20 peptidase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ TNF alpha induced protein 3 — part of (P361): OTU domain, protein family. wikidata.org.
[6] ↑ TNF alpha induced protein 3 — part of (P361): Zinc finger, A20-type, protein family. wikidata.org.
[7] ↑ TNF alpha induced protein 3 — MeSH descriptor ID (P486): C076529. wikidata.org.
[8] ↑ TNF alpha induced protein 3 — has part(s) (P527): Zinc finger, A20-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ TNF alpha induced protein 3 — has part(s) (P527): OTU domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ TNF alpha induced protein 3 — RefSeq protein ID (P637): NP_001257436. Q20641742. Retrieved 2020-05-30. wikidata.org.
[11] ↑ TNF alpha induced protein 3 — RefSeq protein ID (P637): NP_001257437. Q20641742. Retrieved 2020-05-30. wikidata.org.
[12] ↑ TNF alpha induced protein 3 — RefSeq protein ID (P637): NP_006281. Q20641742. Retrieved 2020-05-30. wikidata.org.
[13] ↑ TNF alpha induced protein 3 — RefSeq protein ID (P637): XP_005267176. Q20641742. Retrieved 2020-05-30. wikidata.org.
[14] ↑ TNF alpha induced protein 3 — RefSeq protein ID (P637): XP_006715618. Q20641742. Retrieved 2020-05-30. wikidata.org.
[15] ↑ TNF alpha induced protein 3 — RefSeq protein ID (P637): XP_011534397. Q20641742. Retrieved 2020-05-30. wikidata.org.
[16] ↑ TNF alpha induced protein 3 — RefSeq protein ID (P637): XP_011534398. Q20641742. Retrieved 2020-05-30. wikidata.org.
[17] ↑ TNF alpha induced protein 3 — RefSeq protein ID (P637): XP_024302300. Q20641742. Retrieved 2020-05-30. wikidata.org.
[18] ↑ TNF alpha induced protein 3 — RefSeq protein ID (P637): XP_024302301. Q20641742. Retrieved 2020-05-30. wikidata.org.
[19] ↑ TNF alpha induced protein 3 — PDB structure ID (P638): 2EQF. Q905695. Retrieved 2016-08-09. wikidata.org.
[20] ↑ TNF alpha induced protein 3 — PDB structure ID (P638): 2EQG. Q905695. Retrieved 2016-08-09. wikidata.org.
[21] ↑ TNF alpha induced protein 3 — PDB structure ID (P638): 2VFJ. Q905695. Retrieved 2016-08-09. wikidata.org.
[22] ↑ TNF alpha induced protein 3 — PDB structure ID (P638): 3DKB. Q905695. Retrieved 2016-08-09. wikidata.org.
[23] ↑ TNF alpha induced protein 3 — PDB structure ID (P638): 3OJ3. Q905695. Retrieved 2016-08-09. wikidata.org.
[24] ↑ TNF alpha induced protein 3 — PDB structure ID (P638): 3OJ4. Q905695. Retrieved 2016-08-09. wikidata.org.
[25] ↑ TNF alpha induced protein 3 — PDB structure ID (P638): 3VUW. Q905695. Retrieved 2016-08-09. wikidata.org.
[26] ↑ TNF alpha induced protein 3 — PDB structure ID (P638): 3VUX. Q905695. Retrieved 2016-08-09. wikidata.org.

Class ancestry

[1] ↑ TNF alpha induced protein 3 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). TNF alpha induced protein 3. Retrieved May 3, 2026, from https://4ort.xyz/entity/tnf-alpha-induced-protein-3-q21109230

MLA

“TNF alpha induced protein 3.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/tnf-alpha-induced-protein-3-q21109230.

BibTeX

@misc{4ortxyz_tnf-alpha-induced-protein-3-q21109230_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{TNF alpha induced protein 3}}, year = {2026}, url = {https://4ort.xyz/entity/tnf-alpha-induced-protein-3-q21109230}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): TNF alpha induced protein 3 — https://4ort.xyz/entity/tnf-alpha-induced-protein-3-q21109230 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/tnf-alpha-induced-protein-3-q21109230 · Last refreshed: May 3, 2026