Thrombospondin 1

mammalian protein found in Homo sapiens

Protein protein Q3822573

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Thrombospondin 1

Summary

Thrombospondin 1 is a protein^[1].

Key Facts

Thrombospondin 1's instance of is recorded as protein^[2].
Thrombospondin 1's UniProt protein ID is recorded as P07996^[3].
Thrombospondin 1's part of is recorded as TSP type-3 repeat^[4].
Thrombospondin 1's part of is recorded as Concanavalin A-like lectin/glucanase domain superfamily^[5].
Thrombospondin 1's part of is recorded as Thrombospondin type-1 (TSP1) repeat superfamily^[6].
Thrombospondin 1's part of is recorded as thrombospondin-1^[7].
Thrombospondin 1's part of is recorded as Thrombospondin, C-terminal domain, protein family^[8].
Thrombospondin 1's part of is recorded as Laminin G domain, protein family^[9].
Thrombospondin 1's part of is recorded as VWFC domain, protein family^[10].
Thrombospondin 1's part of is recorded as EGF-like calcium-binding domain, protein family^[11].
Thrombospondin 1's part of is recorded as EGF-like domain, protein family^[12].
Thrombospondin 1's part of is recorded as Thrombospondin, type 3-like repeat, protein family^[13].
Thrombospondin 1's part of is recorded as EGF-like, conserved site, protein family^[14].
Thrombospondin 1's part of is recorded as Thrombospondin type-1 (TSP1) repeat, protein family^[15].
Thrombospondin 1's part of is recorded as Thrombospondin, type 3 repeat, protein family^[16].
Thrombospondin 1's has part is recorded as Thrombospondin type-1 (TSP1) repeat^[17].
Thrombospondin 1's has part is recorded as EGF-like, conserved site^[18].
Thrombospondin 1's has part is recorded as Thrombospondin, C-terminal^[19].
Thrombospondin 1's has part is recorded as VWFC domain^[20].
Thrombospondin 1's has part is recorded as Thrombospondin, type 3 repeat^[21].
Thrombospondin 1's has part is recorded as Laminin G domain^[22].
Thrombospondin 1's has part is recorded as Thrombospondin, type 3-like repeat^[23].
Thrombospondin 1's has part is recorded as EGF-like domain^[24].
Thrombospondin 1's has part is recorded as EGF-like calcium-binding domain^[25].
Thrombospondin 1's RefSeq protein ID is recorded as NP_003237^[26].

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Quick Facts

Instance of protein

Part of TSP type-3 repeat, Concanavalin A-like lectin/glucanase domain superfamily, Thrombospondin type-1 (TSP1) repeat superfamily, thrombospondin-1, Thrombospondin, C-terminal domain, protein family, Laminin G domain, protein family, VWFC domain, protein family, EGF-like calcium-binding domain, protein family, EGF-like domain, protein family, Thrombospondin, type 3-like repeat, protein family, EGF-like, conserved site, protein family, Thrombospondin type-1 (TSP1) repeat, protein family, Thrombospondin, type 3 repeat, protein family

Properties

Biological process positive regulation of transforming growth factor beta receptor signaling pathway, cellular response to heat, negative regulation of fibrinolysis, protein O-linked fucosylation, response to progesterone, response to magnesium ion, positive regulation of translation, negative regulation of endothelial cell migration, negative regulation of cell-matrix adhesion, negative regulation of long-chain fatty acid import across plasma membrane, positive regulation of reactive oxygen species metabolic process, positive regulation of blood coagulation, positive regulation of blood vessel endothelial cell migration, positive regulation of macrophage chemotaxis, positive regulation of protein kinase B signaling, negative regulation of plasminogen activation, negative regulation of blood vessel endothelial cell migration, negative regulation of extrinsic apoptotic signaling pathway, response to endoplasmic reticulum stress, positive regulation of endothelial cell apoptotic process, response to unfolded protein, positive regulation of chemotaxis, negative regulation of cGMP-mediated signaling, positive regulation of phosphorylation, inflammatory response, negative regulation of focal adhesion assembly, chronic inflammatory response, negative regulation of nitric oxide mediated signal transduction, engulfment of apoptotic cell, extracellular matrix organization, positive regulation of macrophage activation, sprouting angiogenesis, negative regulation of apoptotic process, response to glucose, positive regulation of angiogenesis, response to calcium ion, positive regulation of transforming growth factor beta1 production, cell adhesion, behavioral response to pain, immune response, negative regulation of interleukin-12 production, positive regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, response to hypoxia, positive regulation of cell migration, platelet degranulation, negative regulation of endothelial cell chemotaxis, negative regulation of endothelial cell proliferation, positive regulation of endothelial cell migration, negative regulation of fibroblast growth factor receptor signaling pathway, peptide cross-linking, negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, negative regulation of dendritic cell antigen processing and presentation, negative regulation of angiogenesis, cell migration, positive regulation of fibroblast migration, response to testosterone, cellular response to tumor necrosis factor, cellular response to growth factor stimulus, positive regulation of transforming growth factor beta production, response to mechanical stimulus, positive regulation of cell population proliferation, positive regulation of smooth muscle cell proliferation, regulation of megakaryocyte differentiation, inflammatory response, negative regulation of angiogenesis, positive regulation of transforming growth factor beta receptor signaling pathway, negative regulation of cell migration involved in sprouting angiogenesis, negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis, negative regulation of sprouting angiogenesis

Cell component endoplasmic reticulum lumen, platelet alpha granule, cell surface, endoplasmic reticulum, extracellular exosome, extracellular matrix, secretory granule, platelet alpha granule lumen, fibrinogen complex, sarcoplasmic reticulum, external side of plasma membrane, cytoplasm, extracellular space, extracellular region, extracellular region, extracellular space, cell surface, extracellular matrix, platelet alpha granule, collagen-containing extracellular matrix, extracellular exosome, extracellular space, extracellular matrix, collagen-containing extracellular matrix

Encoded by THBS1

Found in taxon Homo sapiens

Has part(s) Thrombospondin type-1 (TSP1) repeat, EGF-like, conserved site, Thrombospondin, C-terminal, VWFC domain, Thrombospondin, type 3 repeat, Laminin G domain, Thrombospondin, type 3-like repeat, EGF-like domain, EGF-like calcium-binding domain

Imported from wholeness_audit_2026-05-02

Molecular function calcium ion binding, heparin binding, extracellular matrix binding, fibroblast growth factor binding, phosphatidylserine binding, proteoglycan binding, collagen V binding, fibrinogen binding, low-density lipoprotein particle binding, integrin binding, laminin binding, fibronectin binding, identical protein binding, transforming growth factor beta binding, protein binding, extracellular matrix structural constituent, extracellular matrix structural constituent, extracellular matrix structural constituent

External References (4)

Ensembl protein id ENSP00000260356, ENSP00000380720

Pdb structure id 1LSL, 1UX6, 1Z78, 1ZA4, 2ERF, 2ES3, 2OUH, 2OUJ, 3R6B, 5FOE

Refseq protein id NP_003237, XP_011520273

Uniprot protein id P07996

🏷️ Also known as

en glycoprotein G en THBS1 en thrombospondin-1 en Thrombospondin 1 en thrombospondin-1p180 en thrombospondin-p50 ru TSP-1 ru TSP1 ru Тромбоспондин 1 ru Тромбоспондин-1

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Thrombospondin 1 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Thrombospondin 1 — UniProt protein ID (P352): P07996. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ Thrombospondin 1 — part of (P361): TSP type-3 repeat. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Thrombospondin 1 — part of (P361): Concanavalin A-like lectin/glucanase domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Thrombospondin 1 — part of (P361): Thrombospondin type-1 (TSP1) repeat superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Thrombospondin 1 — part of (P361): thrombospondin-1. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Thrombospondin 1 — part of (P361): Thrombospondin, C-terminal domain, protein family. wikidata.org.
[9] ↑ Thrombospondin 1 — part of (P361): Laminin G domain, protein family. wikidata.org.
[10] ↑ Thrombospondin 1 — part of (P361): VWFC domain, protein family. wikidata.org.
[11] ↑ Thrombospondin 1 — part of (P361): EGF-like calcium-binding domain, protein family. wikidata.org.
[12] ↑ Thrombospondin 1 — part of (P361): EGF-like domain, protein family. wikidata.org.
[13] ↑ Thrombospondin 1 — part of (P361): Thrombospondin, type 3-like repeat, protein family. wikidata.org.
[14] ↑ Thrombospondin 1 — part of (P361): EGF-like, conserved site, protein family. wikidata.org.
[15] ↑ Thrombospondin 1 — part of (P361): Thrombospondin type-1 (TSP1) repeat, protein family. wikidata.org.
[16] ↑ Thrombospondin 1 — part of (P361): Thrombospondin, type 3 repeat, protein family. wikidata.org.
[17] ↑ Thrombospondin 1 — has part(s) (P527): Thrombospondin type-1 (TSP1) repeat. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Thrombospondin 1 — has part(s) (P527): EGF-like, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Thrombospondin 1 — has part(s) (P527): Thrombospondin, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Thrombospondin 1 — has part(s) (P527): VWFC domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Thrombospondin 1 — has part(s) (P527): Thrombospondin, type 3 repeat. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Thrombospondin 1 — has part(s) (P527): Laminin G domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Thrombospondin 1 — has part(s) (P527): Thrombospondin, type 3-like repeat. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Thrombospondin 1 — has part(s) (P527): EGF-like domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Thrombospondin 1 — has part(s) (P527): EGF-like calcium-binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Thrombospondin 1 — RefSeq protein ID (P637): NP_003237. Q20641742. Retrieved 2020-05-30. wikidata.org.

Class ancestry

[1] ↑ Thrombospondin 1 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Thrombospondin 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/thrombospondin-1

MLA “Thrombospondin 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/thrombospondin-1.

BibTeX

@misc{4ortxyz_thrombospondin-1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Thrombospondin 1}}, year = {2026}, url = {https://4ort.xyz/entity/thrombospondin-1}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Thrombospondin 1 — https://4ort.xyz/entity/thrombospondin-1 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/thrombospondin-1 · Last refreshed: May 3, 2026