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thrombopoietin

mammalian protein found in Homo sapiens
Protein protein Q424519

Facts

9 properties
Instance of
protein
Part of
four-helical cytokine-like, core, thrombopoeitin, Erythropoietin/thrombopoeitin, conserved site, protein family[2][3][4]
Biological process
multicellular organism development, positive regulation of hematopoietic stem cell proliferation, cell population proliferation, regulation of signaling receptor activity, positive regulation of protein phosphorylation, thrombopoietin-mediated signaling pathway, positive regulation of megakaryocyte differentiation, positive regulation of protein kinase B signaling, positive regulation of ERK1 and ERK2 cascade, positive regulation of protein phosphorylation, positive regulation of cell population proliferation, myeloid cell differentiation, thrombopoietin-mediated signaling pathway, positive regulation of megakaryocyte differentiation, positive regulation of protein kinase B signaling, positive regulation of ERK1 and ERK2 cascade, positive regulation of hematopoietic stem cell proliferation, positive regulation of cell population proliferation, megakaryocyte development, thrombopoietin-mediated signaling pathway, positive regulation of MAPK cascade, positive regulation of protein kinase B signaling, receptor signaling pathway via STAT
Cell component
extracellular region, extracellular space, extracellular region
Encoded by
THPO
Found in taxon
Homo sapiens
Has part(s)
Erythropoietin/thrombopoeitin, conserved site[5]
Has parts
Erythropoietin/thrombopoeitin, conserved site
Molecular function
cytokine activity, growth factor activity, hormone activity, signaling receptor binding[6][7][8]
🏷️ Also known as
en thrombopoietin en MPL ligand en myeloproliferative leukemia virus oncogene ligand en prepro-thrombopoietin en THPO en c-mpl ligand en megakaryocyte colony-stimulating factor en megakaryocyte growth and development factor en megakaryocyte stimulating factor en MGDF en ML ar ثرومبوبويتين cs Trombopoetin de Thrombopoetin de Thrombopoietin es TPO es trombopoyetina fa ترومبوپویتین fr THPO fr thrombopoïétine
🔖 Identifiers · 16
OpenAlex ID
C2777863708
Image (Wikimedia Commons)
Protein THPO PDB 1v7m.png ↗
DeCS ID
14311
Ensembl protein ID
ENSP00000410763, ENSP00000411704, ENSP00000494281, ENSP00000495689, ENSP00000494504, ENSP00000497233, ENSP00000497904
Exact match
purl.uniprot.org
Freebase ID
/m/02lfgj
Gran Enciclopèdia Catalana ID
trombopoetina
Gran Enciclopèdia Catalana ID (former scheme)
0282526
Microsoft Academic ID (discontinued)
2777863708
NE.se ID
trombopoetin
PDB structure ID
1V7M, 1V7N
RefSeq protein ID
NP_000451, NP_001171068, NP_001171069, NP_001276926, NP_001276927, NP_001276932, NP_001276951, NP_001276955, NP_001276956, NP_001276957, XP_016862596
Show all 16 identifiers +4
Treccani's Dizionario di Medicina ID
trombopoietina
UMLS CUI
C0040052
UniProt protein ID
P40225
WikiSkripta article ID
15525

Report an error or request removal Lineage (PROV-JSON)

🔗 Connections
Biological process 1
cell population proliferation
Cell component 1
extracellular space
Found in taxon 1
Homo sapiens
Instance of 1
protein
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Summary

thrombopoietin is a protein[1].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [4] ↑ . wikidata.org.
  4. [5] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  5. [6] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  6. [7] ↑ . Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  7. [8] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). thrombopoietin. Retrieved November 3, 2026, from https://4ort.xyz/entity/thrombopoietin
MLA “thrombopoietin.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 Nov. 2026, https://4ort.xyz/entity/thrombopoietin.
BibTeX @misc{4ortxyz_thrombopoietin_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{thrombopoietin}}, year = {2026}, url = {https://4ort.xyz/entity/thrombopoietin}, note = {Accessed: 2026-11-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): thrombopoietin — https://4ort.xyz/entity/thrombopoietin (retrieved 2026-11-03)

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