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thrombomodulin

mammalian protein found in Homo sapiens
Protein protein Q414446

Facts

8 properties
Instance of
protein
Part of
thrombomodulin, C-type lectin-like/link domain superfamily, Growth factor receptor cysteine-rich domain superfamily, C-type lectin fold, Thrombomodulin-like, EGF-like, protein family, C-type lectin-like domain, protein family, EGF-like calcium-binding domain, protein family, EGF-like domain, protein family, EGF-like, conserved site, protein family, Complement Clr-like EGF domain, protein family, EGF-like calcium-binding, conserved site, protein family[1][2][3][4][5][6][7][8][9][10][11]
Biological process
hemostasis, female pregnancy, negative regulation of platelet activation, response to lipopolysaccharide, response to cAMP, negative regulation of fibrinolysis, blood coagulation, response to X-ray, signal transduction, negative regulation of blood coagulation, leukocyte migration[32][33][34][35][36][37][38][39][40][41][42]
Cell component
integral component of membrane, cell surface, plasma membrane, integral component of plasma membrane, membrane, apicolateral plasma membrane, vacuolar membrane, extracellular space[24][25][26][27][28][29][30][31]
Encoded by
THBD[43]
Found in taxon
Homo sapiens[44]
Has part(s)
EGF-type aspartate/asparagine hydroxylation site, EGF-like calcium-binding, conserved site, EGF-like, conserved site, Complement Clr-like EGF domain, C-type lectin-like domain, Thrombomodulin-like, EGF-like, EGF-like calcium-binding domain, EGF-like domain[12][13][14][15][16][17][18][19]
Molecular function
calcium ion binding, protein binding, transmembrane signaling receptor activity, signaling receptor activity[20][21][22][23]
🏷️ Also known as
en CD141 antigen en fetomodulin en THBD en thrombomodulin es Trombomodulina fa ترومبومودولین fi trombomoduliini fr Thrombomoduline it CD141 ja トロンボモジュリン ru Тромбомодулин sv trombomodulin uk Тромбомодулін zh 血栓调节蛋白
🔖 Identifiers · 9
OpenAlex ID
C201267052
Ensembl protein ID
ENSP00000366307
Exact match
purl.uniprot.org
Freebase ID
/m/0bdsd5
Microsoft Academic ID (discontinued)
201267052
PDB structure ID
1ADX, 1DQB, 1DX5, 1EGT, 1FGD, 1FGE, 1HLT, 1TMR, 1ZAQ, 2ADX, 3GIS
RefSeq protein ID
NP_000352
UniProt protein ID
P07204
YSO ID
28994

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🔗 Connections
Biological process 3
blood coagulation, hemostasis, signal transduction
Cell component 2
plasma membrane, extracellular space
Found in taxon 1
Homo sapiens
Has part(s) 1
C-type lectin-like domain
Instance of 1
protein
Molecular function 1
protein binding
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References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [1] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [2] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  5. [5] ↑ . wikidata.org.
  6. [6] ↑ . wikidata.org.
  7. [7] ↑ . wikidata.org.
  8. [8] ↑ . wikidata.org.
  9. [9] ↑ . wikidata.org.
  10. [10] ↑ . wikidata.org.
  11. [11] ↑ . wikidata.org.
  12. [12] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  13. [13] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  14. [14] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  15. [15] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  16. [16] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  17. [17] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  18. [18] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  19. [19] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  20. [20] ↑ . The interaction of thrombomodulin with Ca2+. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [21] ↑ . Two different proteins that compete for binding to thrombin have opposite kinetic and thermodynamic profiles. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [23] ↑ . Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [25] ↑ . Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [26] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [27] ↑ . Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [28] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [29] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  30. [30] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  31. [31] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  32. [32] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  33. [33] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  34. [34] ↑ . Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  35. [35] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  36. [36] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  37. [37] ↑ . Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  38. [38] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  39. [39] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  40. [40] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  41. [41] ↑ . Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  42. [42] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  43. [43] ↑ . UniProt. Retrieved . wikidata.org.
  44. [44] ↑ . UniProt. Retrieved . wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). thrombomodulin. Retrieved November 7, 2026, from https://4ort.xyz/entity/thrombomodulin
MLA “thrombomodulin.” 4ort.xyz Knowledge Graph, 4ort.xyz, 7 Nov. 2026, https://4ort.xyz/entity/thrombomodulin.
BibTeX @misc{4ortxyz_thrombomodulin_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{thrombomodulin}}, year = {2026}, url = {https://4ort.xyz/entity/thrombomodulin}, note = {Accessed: 2026-11-07}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 24w ago · Twofivesixbot bot · 2026-05-19 view diff on Wikidata ↗
    Found in taxon → Homo sapiens
    Encoded by → THBD
    Instance of → —
    Aliases → —
    + 8 other properties edited (see Wikidata diff for full list)
    "/* wbsetclaim-update-qualifiers:1||1|4 */ YSO ID: 28994, mv to monolingual text names on YSO statements"
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