T-box18

mammalian protein found in Mus musculus

Protein protein Q21980217

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T-box18

Summary

T-box18 is a protein^[1].

Key Facts

T-box18's instance of is recorded as protein^[2].
T-box18's subclass of is recorded as protein^[3].
T-box18's UniProt protein ID is recorded as Q9EPZ6^[4].
T-box18's part of is recorded as p53-like transcription factor, DNA-binding^[5].
T-box18's part of is recorded as Transcription factor, T-box^[6].
T-box18's part of is recorded as T-box superfamily^[7].
T-box18's part of is recorded as Transcription factor, T-box, conserved site, protein family^[8].
T-box18's has part is recorded as Transcription factor, T-box, conserved site^[9].
T-box18's RefSeq protein ID is recorded as NP_076303^[10].
T-box18's molecular function is recorded as DNA binding^[11].
T-box18's molecular function is recorded as transcription corepressor activity^[12].
T-box18's molecular function is recorded as protein homodimerization activity^[13].
T-box18's molecular function is recorded as DNA-binding transcription factor activity^[14].
T-box18's molecular function is recorded as transcription cis-regulatory region binding^[15].
T-box18's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[16].
T-box18's molecular function is recorded as DNA-binding transcription repressor activity, RNA polymerase II-specific^[17].
T-box18's molecular function is recorded as protein binding^[18].
T-box18's molecular function is recorded as protein heterodimerization activity^[19].
T-box18's cell component is recorded as Tle3-Aes complex^[20].
T-box18's cell component is recorded as nucleus^[21].
T-box18's biological process is recorded as somitogenesis^[22].
T-box18's biological process is recorded as renal system development^[23].
T-box18's biological process is recorded as cell differentiation^[24].
T-box18's biological process is recorded as ureter development^[25].
T-box18's biological process is recorded as regulation of transcription, DNA-templated^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of p53-like transcription factor, DNA-binding, Transcription factor, T-box, T-box superfamily, Transcription factor, T-box, conserved site, protein family

Properties

Biological process somitogenesis, renal system development, cell differentiation, ureter development, regulation of transcription, DNA-templated, positive regulation of cell-cell adhesion, positive regulation of epithelial cell proliferation, anatomical structure formation involved in morphogenesis, negative regulation of transcription by RNA polymerase II, hearing, smooth muscle cell differentiation, transcription, DNA-templated, sinoatrial node development, multicellular organism development, negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation, positive regulation of mesenchymal cell proliferation, cochlea morphogenesis, positive regulation of mesenchymal cell proliferation involved in ureter development, morphogenesis of embryonic epithelium, anterior/posterior axis specification

Cell component Tle3-Aes complex, nucleus

Encoded by Tbx18

Found in taxon house mouse

Has part(s) Transcription factor, T-box, conserved site

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, transcription corepressor activity, protein homodimerization activity, DNA-binding transcription factor activity, transcription cis-regulatory region binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, protein binding, protein heterodimerization activity

External References (3)

Ensembl protein id ENSMUSP00000034991

Refseq protein id NP_076303

Uniprot protein id Q9EPZ6

🏷️ Also known as

en T-box18 en T-box protein 18 en T-box transcription factor TBX18 en Tbx18

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ T-box18 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ T-box18 — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ T-box18 — UniProt protein ID (P352): Q9EPZ6. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ T-box18 — part of (P361): p53-like transcription factor, DNA-binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ T-box18 — part of (P361): Transcription factor, T-box. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ T-box18 — part of (P361): T-box superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ T-box18 — part of (P361): Transcription factor, T-box, conserved site, protein family. wikidata.org.
[9] ↑ T-box18 — has part(s) (P527): Transcription factor, T-box, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ T-box18 — RefSeq protein ID (P637): NP_076303. Q20641742. Retrieved 2022-03-20. wikidata.org.
[11] ↑ T-box18 — molecular function (P680): DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ T-box18 — molecular function (P680): transcription corepressor activity. Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors. Retrieved 2018-03-27. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ T-box18 — molecular function (P680): protein homodimerization activity. Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ T-box18 — molecular function (P680): DNA-binding transcription factor activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ T-box18 — molecular function (P680): transcription cis-regulatory region binding. Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ T-box18 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ T-box18 — molecular function (P680): DNA-binding transcription repressor activity, RNA polymerase II-specific. Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors. Retrieved 2018-10-11. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ T-box18 — molecular function (P680): protein binding. SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation.. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ T-box18 — molecular function (P680): protein heterodimerization activity. Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ T-box18 — cell component (P681): Tle3-Aes complex. Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ T-box18 — cell component (P681): nucleus. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ T-box18 — biological process (P682): somitogenesis. The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ T-box18 — biological process (P682): renal system development. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ T-box18 — biological process (P682): cell differentiation. Deafness in mice lacking the T-box transcription factor Tbx18 in otic fibrocytes. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ T-box18 — biological process (P682): ureter development. Hydroureternephrosis due to loss of Sox9-regulated smooth muscle cell differentiation of the ureteric mesenchyme. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ T-box18 — biological process (P682): regulation of transcription, DNA-templated. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ T-box18 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). T-box18. Retrieved May 3, 2026, from https://4ort.xyz/entity/t-box18

MLA “T-box18.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/t-box18.

BibTeX

@misc{4ortxyz_t-box18_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{T-box18}}, year = {2026}, url = {https://4ort.xyz/entity/t-box18}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): T-box18 — https://4ort.xyz/entity/t-box18 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/t-box18 · Last refreshed: May 3, 2026