T-box 1

mammalian protein found in Mus musculus

Protein protein Q21980210

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T-box 1

Summary

T-box 1 is a protein^[1].

Key Facts

T-box 1's instance of is recorded as protein^[2].
T-box 1's subclass of is recorded as protein^[3].
T-box 1's UniProt protein ID is recorded as P70323^[4].
T-box 1's part of is recorded as p53-like transcription factor, DNA-binding^[5].
T-box 1's part of is recorded as Transcription factor, T-box^[6].
T-box 1's part of is recorded as T-box superfamily^[7].
T-box 1's part of is recorded as Transcription factor, T-box, conserved site, protein family^[8].
T-box 1's has part is recorded as Transcription factor, T-box, conserved site^[9].
T-box 1's RefSeq protein ID is recorded as NP_001272401^[10].
T-box 1's RefSeq protein ID is recorded as NP_001272405^[11].
T-box 1's RefSeq protein ID is recorded as NP_035662^[12].
T-box 1's RefSeq protein ID is recorded as XP_006522041^[13].
T-box 1's RefSeq protein ID is recorded as XP_006522042^[14].
T-box 1's RefSeq protein ID is recorded as XP_017172414^[15].
T-box 1's molecular function is recorded as sequence-specific DNA binding^[16].
T-box 1's molecular function is recorded as protein homodimerization activity^[17].
T-box 1's molecular function is recorded as DNA-binding transcription factor activity^[18].
T-box 1's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[19].
T-box 1's molecular function is recorded as protein binding^[20].
T-box 1's molecular function is recorded as RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding^[21].
T-box 1's molecular function is recorded as DNA binding^[22].
T-box 1's cell component is recorded as nucleus^[23].
T-box 1's biological process is recorded as pattern specification process^[24].
T-box 1's biological process is recorded as negative regulation of mesenchymal cell apoptotic process^[25].
T-box 1's biological process is recorded as cellular response to retinoic acid^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of p53-like transcription factor, DNA-binding, Transcription factor, T-box, T-box superfamily, Transcription factor, T-box, conserved site, protein family

Properties

Biological process pattern specification process, negative regulation of mesenchymal cell apoptotic process, cellular response to retinoic acid, positive regulation of protein phosphorylation, semicircular canal morphogenesis, regulation of transcription, DNA-templated, epithelial cell differentiation, blood vessel morphogenesis, muscle organ morphogenesis, tongue morphogenesis, positive regulation of tongue muscle cell differentiation, positive regulation of epithelial cell proliferation, thymus development, mesenchymal cell apoptotic process, cell fate specification, regulation of transcription by RNA polymerase II, negative regulation of cell differentiation, muscle cell fate commitment, soft palate development, coronary artery morphogenesis, muscle organ development, heart morphogenesis, outflow tract morphogenesis, vagus nerve morphogenesis, otic vesicle morphogenesis, outer ear morphogenesis, negative regulation of transcription by RNA polymerase II, hearing, cellular response to fibroblast growth factor stimulus, aorta morphogenesis, lymph vessel development, transcription, DNA-templated, outflow tract septum morphogenesis, multicellular organism development, ear morphogenesis, odontogenesis of dentin-containing tooth, development of the heart, blood vessel remodeling, thyroid gland development, determination of left/right symmetry, retinoic acid receptor signaling pathway, blood vessel development, positive regulation of mesenchymal cell proliferation, parathyroid gland development, inner ear morphogenesis, muscle tissue morphogenesis, cochlea morphogenesis, angiogenesis, neural crest cell migration, positive regulation of cell population proliferation, artery morphogenesis, middle ear morphogenesis, branching involved in blood vessel morphogenesis, social behavior, embryonic cranial skeleton morphogenesis, embryonic viscerocranium morphogenesis, positive regulation of secondary heart field cardioblast proliferation, enamel mineralization, mesoderm development, cell population proliferation, face morphogenesis, anterior/posterior pattern specification, positive regulation of MAPK cascade, positive regulation of transcription by RNA polymerase II, pharyngeal system development, regulation of animal organ morphogenesis, transcription by RNA polymerase II, positive regulation of transcription, DNA-templated

Cell component nucleus

Encoded by Tbx1

Found in taxon house mouse

Has part(s) Transcription factor, T-box, conserved site

Imported from wholeness_audit_2026-05-02

Molecular function sequence-specific DNA binding, protein homodimerization activity, DNA-binding transcription factor activity, DNA-binding transcription activator activity, RNA polymerase II-specific, protein binding, RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding, DNA binding

External References (3)

Ensembl protein id ENSMUSP00000009241

Refseq protein id NP_001272401, NP_001272405, NP_035662, XP_006522041, XP_006522042, XP_017172414

Uniprot protein id P70323

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ T-box 1 — instance of (P31): protein. Q905695. Retrieved 2018-01-31. wikidata.org.
[3] ↑ T-box 1 — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ T-box 1 — UniProt protein ID (P352): P70323. Q905695. Retrieved 2018-01-31. wikidata.org.
[5] ↑ T-box 1 — part of (P361): p53-like transcription factor, DNA-binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ T-box 1 — part of (P361): Transcription factor, T-box. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ T-box 1 — part of (P361): T-box superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ T-box 1 — part of (P361): Transcription factor, T-box, conserved site, protein family. wikidata.org.
[9] ↑ T-box 1 — has part(s) (P527): Transcription factor, T-box, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ T-box 1 — RefSeq protein ID (P637): NP_001272401. Q20641742. Retrieved 2018-02-24. wikidata.org.
[11] ↑ T-box 1 — RefSeq protein ID (P637): NP_001272405. Q20641742. Retrieved 2018-02-24. wikidata.org.
[12] ↑ T-box 1 — RefSeq protein ID (P637): NP_035662. Q20641742. Retrieved 2018-02-24. wikidata.org.
[13] ↑ T-box 1 — RefSeq protein ID (P637): XP_006522041. Q20641742. Retrieved 2018-02-24. wikidata.org.
[14] ↑ T-box 1 — RefSeq protein ID (P637): XP_006522042. Q20641742. Retrieved 2018-02-24. wikidata.org.
[15] ↑ T-box 1 — RefSeq protein ID (P637): XP_017172414. Q20641742. Retrieved 2018-02-24. wikidata.org.
[16] ↑ T-box 1 — molecular function (P680): sequence-specific DNA binding. Isolation and Characterization of a Gene from the DiGeorge Chromosomal Region Homologous to the MouseTbx1Gene. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ T-box 1 — molecular function (P680): protein homodimerization activity. Isolation and Characterization of a Gene from the DiGeorge Chromosomal Region Homologous to the MouseTbx1Gene. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ T-box 1 — molecular function (P680): DNA-binding transcription factor activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ T-box 1 — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ T-box 1 — molecular function (P680): protein binding. Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ T-box 1 — molecular function (P680): RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding. Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ T-box 1 — molecular function (P680): DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ T-box 1 — cell component (P681): nucleus. Isolation and Characterization of a Gene from the DiGeorge Chromosomal Region Homologous to the MouseTbx1Gene. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ T-box 1 — biological process (P682): pattern specification process. The del22q11.2 candidate gene Tbx1 regulates branchiomeric myogenesis. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ T-box 1 — biological process (P682): negative regulation of mesenchymal cell apoptotic process. Cooperative function of Tbx1 and Brn4 in the periotic mesenchyme is necessary for cochlea formation. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ T-box 1 — biological process (P682): cellular response to retinoic acid. Retinoic acid down-regulates Tbx1 expression and induces abnormal differentiation of tongue muscles in fetal mice. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ T-box 1 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). T-box 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/t-box-1

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BibTeX

@misc{4ortxyz_t-box-1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{T-box 1}}, year = {2026}, url = {https://4ort.xyz/entity/t-box-1}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): T-box 1 — https://4ort.xyz/entity/t-box-1 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/t-box-1 · Last refreshed: May 3, 2026