Sterol regulatory element binding transcription factor 1

mammalian protein found in Homo sapiens

Protein protein Q21135683

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Summary

Sterol regulatory element binding transcription factor 1 is a protein^[1].

Key Facts

Sterol regulatory element binding transcription factor 1's instance of is recorded as protein^[2].
Sterol regulatory element binding transcription factor 1's UniProt protein ID is recorded as P36956^[3].
Sterol regulatory element binding transcription factor 1's part of is recorded as membrane protein^[4].
Sterol regulatory element binding transcription factor 1's RefSeq protein ID is recorded as NP_001005291^[5].
Sterol regulatory element binding transcription factor 1's RefSeq protein ID is recorded as NP_001308025^[6].
Sterol regulatory element binding transcription factor 1's RefSeq protein ID is recorded as NP_004167^[7].
Sterol regulatory element binding transcription factor 1's RefSeq protein ID is recorded as XP_016880459^[8].
Sterol regulatory element binding transcription factor 1's RefSeq protein ID is recorded as XP_016880460^[9].
Sterol regulatory element binding transcription factor 1's RefSeq protein ID is recorded as XP_024306661^[10].
Sterol regulatory element binding transcription factor 1's RefSeq protein ID is recorded as XP_024306662^[11].
Sterol regulatory element binding transcription factor 1's RefSeq protein ID is recorded as XP_024306663^[12].
Sterol regulatory element binding transcription factor 1's PDB structure ID is recorded as 1AM9^[13].
Sterol regulatory element binding transcription factor 1's molecular function is recorded as DNA binding^[14].
Sterol regulatory element binding transcription factor 1's molecular function is recorded as sequence-specific DNA binding^[15].
Sterol regulatory element binding transcription factor 1's molecular function is recorded as protein dimerization activity^[16].
Sterol regulatory element binding transcription factor 1's molecular function is recorded as DNA-binding transcription factor activity^[17].
Sterol regulatory element binding transcription factor 1's molecular function is recorded as sterol response element binding^[18].
Sterol regulatory element binding transcription factor 1's molecular function is recorded as chromatin binding^[19].
Sterol regulatory element binding transcription factor 1's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[20].
Sterol regulatory element binding transcription factor 1's molecular function is recorded as transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding^[21].
Sterol regulatory element binding transcription factor 1's molecular function is recorded as protein binding^[22].
Sterol regulatory element binding transcription factor 1's molecular function is recorded as protein kinase binding^[23].
Sterol regulatory element binding transcription factor 1's molecular function is recorded as RNA polymerase II transcription regulatory region sequence-specific DNA binding^[24].
Sterol regulatory element binding transcription factor 1's molecular function is recorded as nuclear receptor activity^[25].
Sterol regulatory element binding transcription factor 1's molecular function is recorded as DNA-binding transcription factor activity, RNA polymerase II-specific^[26].

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Quick Facts

Instance of protein

Part of membrane protein

Properties

Biological process positive regulation of histone deacetylation, insulin receptor signaling pathway, positive regulation of triglyceride biosynthetic process, steroid metabolic process, negative regulation of insulin secretion, response to fatty acid, lipid biosynthetic process, response to glucagon, regulation of protein stability, regulation of transcription, DNA-templated, response to retinoic acid, response to organic cyclic compound, lung development, lipid metabolism, regulation of insulin secretion, regulation of transcription by RNA polymerase II, cellular response to starvation, response to progesterone, ageing, response to peptide hormone, mRNA transcription by RNA polymerase II, cholesterol metabolic process, negative regulation of transcription by RNA polymerase II, response to glucose, transcription, DNA-templated, positive regulation of transcription, DNA-templated, response to lipid, cellular response to fatty acid, regulation of autophagy of mitochondrion, regulation of protein targeting to mitochondrion, regulation of fatty acid metabolic process, circadian rhythm, cellular response to insulin stimulus, response to food, positive regulation of cholesterol biosynthetic process, response to cAMP, regulation of heart rate by chemical signal, fat cell differentiation, intracellular receptor signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of cholesterol biosynthetic process, transcription by RNA polymerase II, positive regulation of pri-miRNA transcription by RNA polymerase II, positive regulation of catalytic activity

Cell component cytoplasm, integral component of membrane, cytosol, Golgi apparatus, nuclear envelope, endoplasmic reticulum membrane, membrane, intracellular membrane-bounded organelle, Golgi membrane, nucleoplasm, endoplasmic reticulum, ER to Golgi transport vesicle membrane, cytoplasmic vesicle, nucleus, protein-containing complex, endoplasmic reticulum

Encoded by SREBF1

Found in taxon Homo sapiens

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, sequence-specific DNA binding, protein dimerization activity, DNA-binding transcription factor activity, sterol response element binding, chromatin binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding, protein binding, protein kinase binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, nuclear receptor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription activator activity, RNA polymerase II-specific, protein-containing complex binding, enzyme activator activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription activator activity, RNA polymerase II-specific

External References (4)

Ensembl protein id ENSP00000261646, ENSP00000348069, ENSP00000379106, ENSP00000411516, ENSP00000463474, ENSP00000464923, ENSP00000465747, ENSP00000466453, ENSP00000466643, ENSP00000474121

Pdb structure id 1AM9

Refseq protein id NP_001005291, NP_001308025, NP_004167, XP_016880459, XP_016880460, XP_024306661, XP_024306662, XP_024306663

Uniprot protein id P36956

🏷️ Also known as

en bHLHd1 en class D basic helix-loop-helix protein 1 en SREBF1 en sterol regulatory element-binding protein 1 en Sterol regulatory element binding transcription factor 1 en Sterol regulatory element-binding transcription factor 1

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Sterol regulatory element binding transcription factor 1 — instance of (P31): protein. UniProt. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Sterol regulatory element binding transcription factor 1 — UniProt protein ID (P352): P36956. UniProt. Retrieved 2019-11-13. wikidata.org.
[4] ↑ Sterol regulatory element binding transcription factor 1 — part of (P361): membrane protein. wikidata.org.
[5] ↑ Sterol regulatory element binding transcription factor 1 — RefSeq protein ID (P637): NP_001005291. Q20641742. Retrieved 2020-05-30. wikidata.org.
[6] ↑ Sterol regulatory element binding transcription factor 1 — RefSeq protein ID (P637): NP_001308025. Q20641742. Retrieved 2020-05-30. wikidata.org.
[7] ↑ Sterol regulatory element binding transcription factor 1 — RefSeq protein ID (P637): NP_004167. Q20641742. Retrieved 2020-05-30. wikidata.org.
[8] ↑ Sterol regulatory element binding transcription factor 1 — RefSeq protein ID (P637): XP_016880459. Q20641742. Retrieved 2020-05-30. wikidata.org.
[9] ↑ Sterol regulatory element binding transcription factor 1 — RefSeq protein ID (P637): XP_016880460. Q20641742. Retrieved 2020-05-30. wikidata.org.
[10] ↑ Sterol regulatory element binding transcription factor 1 — RefSeq protein ID (P637): XP_024306661. Q20641742. Retrieved 2020-05-30. wikidata.org.
[11] ↑ Sterol regulatory element binding transcription factor 1 — RefSeq protein ID (P637): XP_024306662. Q20641742. Retrieved 2020-05-30. wikidata.org.
[12] ↑ Sterol regulatory element binding transcription factor 1 — RefSeq protein ID (P637): XP_024306663. Q20641742. Retrieved 2020-05-30. wikidata.org.
[13] ↑ Sterol regulatory element binding transcription factor 1 — PDB structure ID (P638): 1AM9. UniProt. Retrieved 2016-08-09. wikidata.org.
[14] ↑ Sterol regulatory element binding transcription factor 1 — molecular function (P680): DNA binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Sterol regulatory element binding transcription factor 1 — molecular function (P680): sequence-specific DNA binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Sterol regulatory element binding transcription factor 1 — molecular function (P680): protein dimerization activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Sterol regulatory element binding transcription factor 1 — molecular function (P680): DNA-binding transcription factor activity. Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Sterol regulatory element binding transcription factor 1 — molecular function (P680): sterol response element binding. Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Sterol regulatory element binding transcription factor 1 — molecular function (P680): chromatin binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Sterol regulatory element binding transcription factor 1 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Sterol regulatory element binding transcription factor 1 — molecular function (P680): transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding. GOA. Retrieved 2018-06-21. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Sterol regulatory element binding transcription factor 1 — molecular function (P680): protein binding. Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Sterol regulatory element binding transcription factor 1 — molecular function (P680): protein kinase binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Sterol regulatory element binding transcription factor 1 — molecular function (P680): RNA polymerase II transcription regulatory region sequence-specific DNA binding. cAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Sterol regulatory element binding transcription factor 1 — molecular function (P680): nuclear receptor activity. cAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Sterol regulatory element binding transcription factor 1 — molecular function (P680): DNA-binding transcription factor activity, RNA polymerase II-specific. A census of human transcription factors: function, expression and evolution. Retrieved 2018-06-21. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Sterol regulatory element binding transcription factor 1 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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BibTeX

@misc{4ortxyz_sterol-regulatory-element-binding-transcription-factor-1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Sterol regulatory element binding transcription factor 1}}, year = {2026}, url = {https://4ort.xyz/entity/sterol-regulatory-element-binding-transcription-factor-1}, note = {Accessed: 2026-05-03}}

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