SRY-box transcription factor 9

mammalian protein found in Homo sapiens

Protein protein Q21127264

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SRY-box transcription factor 9

Summary

SRY-box transcription factor 9 is a protein^[1].

Key Facts

SRY-box transcription factor 9's instance of is recorded as protein^[2].
SRY-box transcription factor 9's subclass of is recorded as protein^[3].
SRY-box transcription factor 9's UniProt protein ID is recorded as P48436^[4].
SRY-box transcription factor 9's part of is recorded as Transcription factor SOX-9^[5].
SRY-box transcription factor 9's part of is recorded as High mobility group box domain superfamily^[6].
SRY-box transcription factor 9's part of is recorded as High mobility group box domain, protein family^[7].
SRY-box transcription factor 9's part of is recorded as Sox developmental protein N-terminal domain, protein family^[8].
SRY-box transcription factor 9's MeSH descriptor ID is recorded as D055758^[9].
SRY-box transcription factor 9's has part is recorded as Sox developmental protein N-terminal^[10].
SRY-box transcription factor 9's has part is recorded as High mobility group box domain^[11].
SRY-box transcription factor 9's RefSeq protein ID is recorded as NP_000337^[12].
SRY-box transcription factor 9's PDB structure ID is recorded as 4EUW^[13].
SRY-box transcription factor 9's MeSH tree code is recorded as D12.776.260.719.500.500^[14].
SRY-box transcription factor 9's MeSH tree code is recorded as D12.776.660.235.400.750.500.500^[15].
SRY-box transcription factor 9's MeSH tree code is recorded as D12.776.664.235.400.750.500.500^[16].
SRY-box transcription factor 9's MeSH tree code is recorded as D12.776.930.823.500.500^[17].
SRY-box transcription factor 9's molecular function is recorded as DNA-binding transcription factor activity^[18].
SRY-box transcription factor 9's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[19].
SRY-box transcription factor 9's molecular function is recorded as core promoter sequence-specific DNA binding^[20].
SRY-box transcription factor 9's molecular function is recorded as protein kinase activity^[21].
SRY-box transcription factor 9's molecular function is recorded as protein kinase A catalytic subunit binding^[22].
SRY-box transcription factor 9's molecular function is recorded as beta-catenin binding^[23].
SRY-box transcription factor 9's molecular function is recorded as pre-mRNA intronic binding^[24].
SRY-box transcription factor 9's molecular function is recorded as chromatin binding^[25].
SRY-box transcription factor 9's molecular function is recorded as protein binding^[26].

⭐ Popularity Graph

1/100 established

Quick Facts

Instance of protein

Subclass of protein

Part of Transcription factor SOX-9, High mobility group box domain superfamily, High mobility group box domain, protein family, Sox developmental protein N-terminal domain, protein family

Properties

Biological process skeletal system development, cellular response to retinoic acid, bronchus cartilage development, positive regulation of protein phosphorylation, heart valve development, limb bud formation, positive regulation of protein catabolic process, regulation of transcription by RNA polymerase II, ureter morphogenesis, negative regulation of immune system process, chondrocyte development, positive regulation of cell proliferation involved in heart morphogenesis, oligodendrocyte differentiation, chondrocyte hypertrophy, prostate gland development, lung smooth muscle development, mammary gland development, negative regulation of ossification, negative regulation of photoreceptor cell differentiation, cellular response to mechanical stimulus, intrahepatic bile duct development, regulation of cell adhesion, negative regulation of chondrocyte differentiation, positive regulation of mesenchymal cell proliferation, astrocyte fate commitment, positive regulation of chondrocyte differentiation, spermatogenesis, prostate gland morphogenesis, negative regulation of epithelial cell proliferation, lung epithelial cell differentiation, chondrocyte differentiation involved in endochondral bone morphogenesis, negative regulation of canonical Wnt signaling pathway, endocrine pancreas development, negative regulation of cell population proliferation, regulation of apoptotic process, cellular response to transforming growth factor beta stimulus, negative regulation of mesenchymal cell apoptotic process, chromatin remodeling, negative regulation of myoblast differentiation, positive regulation of branching involved in ureteric bud morphogenesis, cell fate commitment, regulation of transcription, DNA-templated, epidermal growth factor receptor signaling pathway, ossification, regulation of cell proliferation involved in tissue homeostasis, ureter smooth muscle cell differentiation, ERK1 and ERK2 cascade, notochord development, positive regulation of epithelial cell migration, Sertoli cell differentiation, male sex determination, negative regulation of gene expression, transcription, DNA-templated, metanephric nephron tubule formation, positive regulation of transcription, DNA-templated, development of the heart, regulation of branching involved in lung morphogenesis, ureter urothelium development, branching involved in ureteric bud morphogenesis, cartilage development, Harderian gland development, positive regulation of kidney development, central nervous system development, heart valve formation, positive regulation of cartilage development, tissue homeostasis, metanephric tubule development, negative regulation of biomineral tissue development, endochondral bone morphogenesis, trachea cartilage development, male germ-line sex determination, lacrimal gland development, Notch signaling pathway, hair follicle development, cell differentiation, ureter development, regulation of cell cycle process, male gonad development, positive regulation of epithelial cell proliferation, cell fate specification, intestinal epithelial structure maintenance, positive regulation of extracellular matrix assembly, extracellular matrix organization, negative regulation of apoptotic process, negative regulation of transcription by RNA polymerase II, Sertoli cell development, positive regulation of mesenchymal stem cell differentiation, retina development in camera-type eye, cellular response to interleukin-1, epithelial to mesenchymal transition, homeostasis of number of cells within a tissue, negative regulation of transcription, DNA-templated, cAMP-mediated signaling, cartilage condensation, positive regulation of male gonad development, nucleosome assembly, negative regulation of bone mineralization, morphogenesis of a branching epithelium, neural crest cell development, protein kinase B signaling, somatic stem cell population maintenance, otic vesicle formation, otic vesicle development, endocardial cushion morphogenesis, cellular response to epidermal growth factor stimulus, positive regulation of epithelial cell differentiation, renal vesicle induction, positive regulation of gene expression, regulation of epithelial cell proliferation involved in lung morphogenesis, regulation of cell population proliferation, heart valve morphogenesis, cytoskeleton organization, cochlea morphogenesis, positive regulation of cell population proliferation, epithelial cell proliferation involved in prostatic bud elongation, retinal rod cell differentiation, protein localization to nucleus, regulation of cell differentiation, positive regulation of phosphatidylinositol 3-kinase signaling, cellular response to heparin, negative regulation of epithelial cell differentiation, epithelial tube branching involved in lung morphogenesis, signal transduction, positive regulation of transcription by RNA polymerase II, negative regulation of pri-miRNA transcription by RNA polymerase II, chondrocyte differentiation, neural crest cell fate specification, cellular response to BMP stimulus, cell-cell adhesion, transcription initiation from RNA polymerase II promoter, protein-containing complex assembly, anterior head development, negative regulation of biomineral tissue development, morphogenesis of an epithelium, chondrocyte differentiation, central nervous system development, development of the heart, positive regulation of chondrocyte differentiation, positive regulation of transcription by RNA polymerase II, oligodendrocyte differentiation, aortic valve morphogenesis, regulation of gene expression, positive regulation of gene expression

Cell component nucleus, transcription regulator complex, nucleoplasm, protein-containing complex, nucleus

Encoded by SOX9

Found in taxon Homo sapiens

Has part(s) Sox developmental protein N-terminal, High mobility group box domain

Imported from wholeness_audit_2026-05-02

Molecular function DNA-binding transcription factor activity, DNA-binding transcription activator activity, RNA polymerase II-specific, core promoter sequence-specific DNA binding, protein kinase activity, protein kinase A catalytic subunit binding, beta-catenin binding, pre-mRNA intronic binding, chromatin binding, protein binding, DNA binding, sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, transcription cis-regulatory region binding, bHLH transcription factor binding, cis-regulatory region sequence-specific DNA binding, protein heterodimerization activity, transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription activator activity, RNA polymerase II-specific

External References (7)

Ensembl protein id ENSP00000245479

Mesh descriptor id D055758

Mesh tree code D12.776.260.719.500.500, D12.776.660.235.400.750.500.500, D12.776.664.235.400.750.500.500, D12.776.930.823.500.500

Pdb structure id 4EUW

Refseq protein id NP_000337

Umls cui C0291784

Uniprot protein id P48436

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ SRY-box transcription factor 9 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ SRY-box transcription factor 9 — subclass of (P279): protein. Q905695. Retrieved 2016-12-01. wikidata.org.
[4] ↑ SRY-box transcription factor 9 — UniProt protein ID (P352): P48436. Q905695. Retrieved 2019-11-13. wikidata.org.
[5] ↑ SRY-box transcription factor 9 — part of (P361): Transcription factor SOX-9. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ SRY-box transcription factor 9 — part of (P361): High mobility group box domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ SRY-box transcription factor 9 — part of (P361): High mobility group box domain, protein family. wikidata.org.
[8] ↑ SRY-box transcription factor 9 — part of (P361): Sox developmental protein N-terminal domain, protein family. wikidata.org.
[9] ↑ SRY-box transcription factor 9 — MeSH descriptor ID (P486): D055758. wikidata.org.
[10] ↑ SRY-box transcription factor 9 — has part(s) (P527): Sox developmental protein N-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ SRY-box transcription factor 9 — has part(s) (P527): High mobility group box domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ SRY-box transcription factor 9 — RefSeq protein ID (P637): NP_000337. Q20641742. Retrieved 2020-05-30. wikidata.org.
[13] ↑ SRY-box transcription factor 9 — PDB structure ID (P638): 4EUW. Q905695. Retrieved 2016-08-04. wikidata.org.
[14] ↑ SRY-box transcription factor 9 — MeSH tree code (P672): D12.776.260.719.500.500. wikidata.org.
[15] ↑ SRY-box transcription factor 9 — MeSH tree code (P672): D12.776.660.235.400.750.500.500. wikidata.org.
[16] ↑ SRY-box transcription factor 9 — MeSH tree code (P672): D12.776.664.235.400.750.500.500. wikidata.org.
[17] ↑ SRY-box transcription factor 9 — MeSH tree code (P672): D12.776.930.823.500.500. wikidata.org.
[18] ↑ SRY-box transcription factor 9 — molecular function (P680): DNA-binding transcription factor activity. Sex reversal by loss of the C-terminal transactivation domain of human SOX9. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ SRY-box transcription factor 9 — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. GOA. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ SRY-box transcription factor 9 — molecular function (P680): core promoter sequence-specific DNA binding. SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium. Retrieved 2018-03-27. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ SRY-box transcription factor 9 — molecular function (P680): protein kinase activity. GOA. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ SRY-box transcription factor 9 — molecular function (P680): protein kinase A catalytic subunit binding. Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ SRY-box transcription factor 9 — molecular function (P680): beta-catenin binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ SRY-box transcription factor 9 — molecular function (P680): pre-mRNA intronic binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ SRY-box transcription factor 9 — molecular function (P680): chromatin binding. The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ SRY-box transcription factor 9 — molecular function (P680): protein binding. SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ SRY-box transcription factor 9 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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MLA

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BibTeX

@misc{4ortxyz_sry-box-transcription-factor-9-q21127264_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{SRY-box transcription factor 9}}, year = {2026}, url = {https://4ort.xyz/entity/sry-box-transcription-factor-9-q21127264}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): SRY-box transcription factor 9 — https://4ort.xyz/entity/sry-box-transcription-factor-9-q21127264 (retrieved 2026-05-03)

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