Spleen tyrosine kinase

mammalian protein found in Mus musculus

Protein protein Q14907340

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Spleen tyrosine kinase

Summary

Spleen tyrosine kinase is a protein^[1].

Key Facts

Spleen tyrosine kinase's instance of is recorded as protein^[2].
Spleen tyrosine kinase's UniProt protein ID is recorded as P48025^[3].
Spleen tyrosine kinase's part of is recorded as tyrosine-protein kinase, non-receptor SYK/ZAP-70^[4].
Spleen tyrosine kinase's part of is recorded as Protein kinase-like domain superfamily^[5].
Spleen tyrosine kinase's part of is recorded as Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily^[6].
Spleen tyrosine kinase's part of is recorded as SH2 domain superfamily^[7].
Spleen tyrosine kinase's part of is recorded as membrane protein^[8].
Spleen tyrosine kinase's part of is recorded as Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family^[9].
Spleen tyrosine kinase's part of is recorded as SH2 domain, protein family^[10].
Spleen tyrosine kinase's part of is recorded as SYK/ZAP-70, N-terminal SH2 domain, protein family^[11].
Spleen tyrosine kinase's part of is recorded as Protein kinase domain, protein family^[12].
Spleen tyrosine kinase's part of is recorded as Protein kinase, ATP binding site, protein family^[13].
Spleen tyrosine kinase's part of is recorded as Tyrosine-protein kinase, catalytic domain, protein family^[14].
Spleen tyrosine kinase's part of is recorded as Tyrosine-protein kinase, active site, protein family^[15].
Spleen tyrosine kinase's has part is recorded as SH2 domain^[16].
Spleen tyrosine kinase's has part is recorded as tyrosine-protein kinase, catalytic domain^[17].
Spleen tyrosine kinase's has part is recorded as tyrosine-protein kinase, active site^[18].
Spleen tyrosine kinase's has part is recorded as serine-threonine/tyrosine-protein kinase, catalytic domain^[19].
Spleen tyrosine kinase's has part is recorded as protein kinase, ATP binding site^[20].
Spleen tyrosine kinase's has part is recorded as protein kinase domain^[21].
Spleen tyrosine kinase's has part is recorded as SYK/ZAP-70, N-terminal SH2 domain^[22].
Spleen tyrosine kinase's RefSeq protein ID is recorded as NP_001185906^[23].
Spleen tyrosine kinase's RefSeq protein ID is recorded as NP_035648^[24].
Spleen tyrosine kinase's RefSeq protein ID is recorded as XP_006516958^[25].
Spleen tyrosine kinase's RefSeq protein ID is recorded as XP_006516960^[26].

⭐ Popularity Graph

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Quick Facts

Instance of protein

Part of tyrosine-protein kinase, non-receptor SYK/ZAP-70, Protein kinase-like domain superfamily, Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily, SH2 domain superfamily, membrane protein, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, SH2 domain, protein family, SYK/ZAP-70, N-terminal SH2 domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Tyrosine-protein kinase, active site, protein family

Properties

Biological process leukocyte cell-cell adhesion, B cell receptor signaling pathway, G protein-coupled receptor signaling pathway, cellular response to molecule of fungal origin, intracellular signal transduction, positive regulation of calcium-mediated signaling, adaptive immune response, blood vessel morphogenesis, phosphorylation, positive regulation of receptor internalization, immune system process, regulation of neutrophil degranulation, positive regulation of B cell differentiation, regulation of tumor necrosis factor-mediated signaling pathway, beta selection, receptor internalization, serotonin secretion by platelet, neutrophil activation involved in immune response, leukocyte activation involved in immune response, cellular response to low-density lipoprotein particle stimulus, positive regulation of bone resorption, lymph vessel development, neutrophil chemotaxis, protein phosphorylation, macrophage activation involved in immune response, cell surface receptor signaling pathway, regulation of arachidonic acid secretion, defense response to bacterium, regulation of DNA-binding transcription factor activity, peptidyl-serine phosphorylation, angiogenesis, serotonin secretion, positive regulation of alpha-beta T cell proliferation, regulation of ERK1 and ERK2 cascade, positive regulation of peptidyl-tyrosine phosphorylation, integrin-mediated signaling pathway, regulation of superoxide anion generation, peptidyl-tyrosine phosphorylation, positive regulation of cell adhesion mediated by integrin, regulation of phagocytosis, regulation of platelet activation, leukotriene biosynthetic process, innate immune response, enzyme linked receptor protein signaling pathway, positive regulation of gamma-delta T cell differentiation, positive regulation of type I interferon production, positive regulation of alpha-beta T cell differentiation, regulation of platelet aggregation, cell migration, collagen-activated tyrosine kinase receptor signaling pathway, positive regulation of peptidyl-tyrosine autophosphorylation, protein import into nucleus, positive regulation of mast cell degranulation, protein autophosphorylation, regulation of immune response, positive regulation of interleukin-4 production, interleukin-3-mediated signaling pathway, macrophage activation involved in immune response, neutrophil activation involved in immune response, positive regulation of cell adhesion mediated by integrin, positive regulation of mast cell degranulation, positive regulation of B cell differentiation, positive regulation of alpha-beta T cell proliferation, B cell receptor signaling pathway, regulation of platelet aggregation, positive regulation of cold-induced thermogenesis, positive regulation of protein-containing complex assembly, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

Cell component cytoplasm, B cell receptor complex, cytosol, membrane, extrinsic component of cytoplasmic side of plasma membrane, early phagosome, plasma membrane, T cell receptor complex, phagocytic vesicle, cytoplasmic vesicle, nucleus, protein-containing complex

Encoded by Syk

Found in taxon house mouse

Has part(s) SH2 domain, tyrosine-protein kinase, catalytic domain, tyrosine-protein kinase, active site, serine-threonine/tyrosine-protein kinase, catalytic domain, protein kinase, ATP binding site, protein kinase domain, SYK/ZAP-70, N-terminal SH2 domain

Imported from wholeness_audit_2026-05-02

Molecular function transferase activity, nucleotide binding, protein kinase activity, non-membrane spanning protein tyrosine kinase activity, kinase activity, integrin binding, protein serine/threonine kinase activity, protein binding, protein tyrosine kinase activity, ATP binding, protein kinase binding, Toll-like receptor binding, phosphatase binding, SH2 domain binding, phosphotyrosine residue binding, protein domain specific binding, ubiquitin protein ligase binding, protein tyrosine kinase activity, interleukin-15 receptor binding, interleukin-15 receptor binding

External References (4)

Ensembl protein id ENSMUSP00000060828, ENSMUSP00000113852, ENSMUSP00000112914

Pdb structure id 2LCT, 2MC1

Refseq protein id NP_001185906, NP_035648, XP_006516958, XP_006516960, XP_017170960, XP_036013851

Uniprot protein id P48025

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Spleen tyrosine kinase — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Spleen tyrosine kinase — UniProt protein ID (P352): P48025. Q905695. Retrieved 2022-05-25. wikidata.org.
[4] ↑ Spleen tyrosine kinase — part of (P361): tyrosine-protein kinase, non-receptor SYK/ZAP-70. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Spleen tyrosine kinase — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Spleen tyrosine kinase — part of (P361): Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Spleen tyrosine kinase — part of (P361): SH2 domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Spleen tyrosine kinase — part of (P361): membrane protein. wikidata.org.
[9] ↑ Spleen tyrosine kinase — part of (P361): Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[10] ↑ Spleen tyrosine kinase — part of (P361): SH2 domain, protein family. wikidata.org.
[11] ↑ Spleen tyrosine kinase — part of (P361): SYK/ZAP-70, N-terminal SH2 domain, protein family. wikidata.org.
[12] ↑ Spleen tyrosine kinase — part of (P361): Protein kinase domain, protein family. wikidata.org.
[13] ↑ Spleen tyrosine kinase — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[14] ↑ Spleen tyrosine kinase — part of (P361): Tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[15] ↑ Spleen tyrosine kinase — part of (P361): Tyrosine-protein kinase, active site, protein family. wikidata.org.
[16] ↑ Spleen tyrosine kinase — has part(s) (P527): SH2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Spleen tyrosine kinase — has part(s) (P527): tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Spleen tyrosine kinase — has part(s) (P527): tyrosine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Spleen tyrosine kinase — has part(s) (P527): serine-threonine/tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Spleen tyrosine kinase — has part(s) (P527): protein kinase, ATP binding site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Spleen tyrosine kinase — has part(s) (P527): protein kinase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Spleen tyrosine kinase — has part(s) (P527): SYK/ZAP-70, N-terminal SH2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Spleen tyrosine kinase — RefSeq protein ID (P637): NP_001185906. Q20641742. Retrieved 2022-03-20. wikidata.org.
[24] ↑ Spleen tyrosine kinase — RefSeq protein ID (P637): NP_035648. Q20641742. Retrieved 2022-03-20. wikidata.org.
[25] ↑ Spleen tyrosine kinase — RefSeq protein ID (P637): XP_006516958. Q20641742. Retrieved 2022-03-20. wikidata.org.
[26] ↑ Spleen tyrosine kinase — RefSeq protein ID (P637): XP_006516960. Q20641742. Retrieved 2022-03-20. wikidata.org.

Class ancestry

[1] ↑ Spleen tyrosine kinase is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Spleen tyrosine kinase. Retrieved May 3, 2026, from https://4ort.xyz/entity/spleen-tyrosine-kinase

MLA

“Spleen tyrosine kinase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/spleen-tyrosine-kinase.

BibTeX

@misc{4ortxyz_spleen-tyrosine-kinase_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Spleen tyrosine kinase}}, year = {2026}, url = {https://4ort.xyz/entity/spleen-tyrosine-kinase}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Spleen tyrosine kinase — https://4ort.xyz/entity/spleen-tyrosine-kinase (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/spleen-tyrosine-kinase · Last refreshed: May 3, 2026