Sphingomyelin phosphodiesterase 3

mammalian protein found in Homo sapiens
Protein protein Q21144907
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Summary

Sphingomyelin phosphodiesterase 3 is a protein[1]. It is known by 6 alternative names across languages and contexts.[2]

Key Facts

  • Part of: Endonuclease/exonuclease/phosphatase superfamily[3], membrane protein[4]
  • Molecular function: sphingomyelin phosphodiesterase activity[5], metal ion binding[6], hydrolase activity[7], protein binding[8], neutral sphingomyelin phosphodiesterase activity[9], phospholipase activity[10]
  • Cell component: Golgi apparatus[11], membrane[12], Golgi membrane[13], Golgi cis cisterna[14], plasma membrane[15], cytoplasm[16]
  • Biological process: positive regulation of ceramide biosynthetic process[17], lipid metabolism[18], multicellular organism development[19], sphingomyelin catabolic process[20], peptide hormone secretion[21], hematopoietic progenitor cell differentiation[22], cell cycle[23], positive regulation of exosomal secretion[24], sphingomyelin metabolic process[25], sphingolipid metabolic process[26], skeletal system development[27], endochondral ossification[28], chondrocyte development[29], regulation of leukocyte migration[30]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [4] ↑ . wikidata.org.
  3. [5] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  4. [6] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  5. [7] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  6. [8] ↑ . The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  7. [9] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [10] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [11] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [12] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [14] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] ↑ . Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [28] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [29] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [30] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Sphingomyelin phosphodiesterase 3. Retrieved May 3, 2026, from https://4ort.xyz/entity/sphingomyelin-phosphodiesterase-3-q21144907
MLA “Sphingomyelin phosphodiesterase 3.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/sphingomyelin-phosphodiesterase-3-q21144907.
BibTeX @misc{4ortxyz_sphingomyelin-phosphodiesterase-3-q21144907_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Sphingomyelin phosphodiesterase 3}}, year = {2026}, url = {https://4ort.xyz/entity/sphingomyelin-phosphodiesterase-3-q21144907}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Sphingomyelin phosphodiesterase 3 — https://4ort.xyz/entity/sphingomyelin-phosphodiesterase-3-q21144907 (retrieved 2026-05-03)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 12w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from → —
    Encoded by → SMPD3
    Wikidata description → mammalian protein found in Homo sapiens
    Molecular function → sphingomyelin phosphodiesterase activity, metal ion binding, hydrolase activity +5
    + 9 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 3.1.4.12, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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