Sonic hedgehog signaling molecule

mammalian protein found in Homo sapiens

Protein protein Q2477760

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Sonic hedgehog signaling molecule

Summary

Sonic hedgehog signaling molecule is a protein^[1].

Key Facts

Sonic hedgehog signaling molecule's instance of is recorded as protein^[2].
Sonic the Hedgehog is named after Sonic hedgehog signaling molecule^[3].
Sonic hedgehog signaling molecule's UniProt protein ID is recorded as Upper Siang district^[4].
Sonic hedgehog signaling molecule's part of is recorded as Hedgehog signalling/DD-peptidase zinc-binding domain superfamily^[5].
Sonic hedgehog signaling molecule's part of is recorded as Hint domain superfamily^[6].
Sonic hedgehog signaling molecule's part of is recorded as hedgehog protein^[7].
Sonic hedgehog signaling molecule's part of is recorded as Hint domain N-terminal domain, protein family^[8].
Sonic hedgehog signaling molecule's part of is recorded as Hint domain C-terminal domain, protein family^[9].
Sonic hedgehog signaling molecule's part of is recorded as Hedgehog protein, Hint domain, protein family^[10].
Sonic hedgehog signaling molecule's part of is recorded as Hedgehog, N-terminal signalling domain, protein family^[11].
Sonic hedgehog signaling molecule's Commons category is recorded as Sonic hedgehog^[12].
Sonic hedgehog signaling molecule's has part is recorded as Hint domain C-terminal^[13].
Sonic hedgehog signaling molecule's has part is recorded as Hint domain N-terminal^[14].
Sonic hedgehog signaling molecule's has part is recorded as Hedgehog, N-terminal signalling domain^[15].
Sonic hedgehog signaling molecule's has part is recorded as Intein N-terminal splicing region^[16].
Sonic hedgehog signaling molecule's has part is recorded as Hedgehog protein, Hint domain^[17].
Sonic hedgehog signaling molecule's RefSeq protein ID is recorded as NP_000184^[18].
Sonic hedgehog signaling molecule's RefSeq protein ID is recorded as NP_001297391^[19].
Sonic hedgehog signaling molecule's RefSeq protein ID is recorded as XP_011514781^[20].
Sonic hedgehog signaling molecule's RefSeq protein ID is recorded as XP_011514782^[21].
Sonic hedgehog signaling molecule's PDB structure ID is recorded as 3HO5^[22].
Sonic hedgehog signaling molecule's PDB structure ID is recorded as 3M1N^[23].
Sonic hedgehog signaling molecule's PDB structure ID is recorded as 3MXW^[24].
Sonic hedgehog signaling molecule's Freebase ID is recorded as /m/01zlqs^[25].
Sonic hedgehog signaling molecule's molecular function is recorded as calcium ion binding^[26].

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Quick Facts

Instance of protein

Part of Hedgehog signalling/DD-peptidase zinc-binding domain superfamily, Hint domain superfamily, hedgehog protein, Hint domain N-terminal domain, protein family, Hint domain C-terminal domain, protein family, Hedgehog protein, Hint domain, protein family, Hedgehog, N-terminal signalling domain, protein family

Properties

Biological process positive regulation of skeletal muscle cell proliferation, pattern specification process, myotube differentiation, mesenchymal cell proliferation, male genitalia development, bud outgrowth involved in lung branching, limb bud formation, T cell differentiation in thymus, embryonic pattern specification, positive regulation of skeletal muscle tissue development, positive regulation of immature T cell proliferation in thymus, positive regulation of kidney smooth muscle cell differentiation, negative regulation of Wnt signaling pathway, anatomical structure formation involved in morphogenesis, ectoderm development, hindgut morphogenesis, spinal cord dorsal/ventral patterning, formation of anatomical boundary, oligodendrocyte differentiation, trachea development, prostate gland development, negative regulation of transcription elongation from RNA polymerase II promoter, limb development, vasculogenesis, primary prostatic bud elongation, heart looping, telencephalon regionalization, odontogenesis of dentin-containing tooth, positive regulation of mesenchymal cell proliferation, angiogenesis, positive regulation of epithelial cell proliferation involved in prostate gland development, positive regulation of striated muscle cell differentiation, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, embryonic digestive tract morphogenesis, apoptotic signaling pathway, inner ear development, hair follicle morphogenesis, cell population proliferation, metanephros development, lung epithelium development, negative regulation of canonical Wnt signaling pathway, regulation of proteolysis, branching involved in salivary gland morphogenesis, negative regulation of mesenchymal cell apoptotic process, positive regulation of neuroblast proliferation, dopaminergic neuron differentiation, intermediate filament organization, renal system development, cell fate commitment, regulation of transcription, DNA-templated, positive regulation of smoothened signaling pathway, androgen metabolic process, kidney development, lung development, negative regulation of protein catabolic process, thymus development, embryonic organ development, negative regulation of cell differentiation, negative regulation of dopaminergic neuron differentiation, embryonic digit morphogenesis, negative regulation of alpha-beta T cell differentiation, positive regulation of sclerotome development, epithelial-mesenchymal cell signaling, negative regulation of gene expression, lymphoid progenitor cell differentiation, negative thymic T cell selection, positive regulation of transcription, DNA-templated, positive regulation of Wnt signaling pathway, ventral midline development, central nervous system development, development of the heart, branching involved in ureteric bud morphogenesis, negative regulation of T cell proliferation, embryonic limb morphogenesis, positive regulation of cell differentiation, branching involved in prostate gland morphogenesis, positive regulation of mesenchymal cell proliferation involved in ureter development, establishment of cell polarity, branching involved in blood vessel morphogenesis, positive regulation of cerebellar granule cell precursor proliferation, neuroblast proliferation, pancreas development, positive regulation of protein import into nucleus, smoothened signaling pathway, oligodendrocyte development, camera-type eye development, spinal cord motor neuron differentiation, positive regulation of alpha-beta T cell differentiation, digestive tract morphogenesis, hair follicle development, positive regulation of oligodendrocyte differentiation, roof of mouth development, left lung development, striated muscle tissue development, positive regulation of T cell differentiation in thymus, cellular response to lithium ion, embryonic foregut morphogenesis, anatomical structure development, thalamus development, stem cell development, smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation, cell fate specification, negative regulation of apoptotic process, negative regulation of transcription by RNA polymerase II, regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry, proteolysis, embryonic skeletal system development, regulation of protein localization to nucleus, odontogenesis, respiratory tube development, regulation of prostatic bud formation, thyroid gland development, negative regulation of cell migration, developmental growth, right lung development, determination of left/right asymmetry in lateral mesoderm, positive thymic T cell selection, mesenchymal smoothened signaling pathway involved in prostate gland development, canonical Wnt signaling pathway, regulation of gene expression, osteoblast development, negative regulation of cholesterol efflux, dorsal/ventral neural tube patterning, regulation of epithelial cell proliferation involved in prostate gland development, epithelial-mesenchymal signaling involved in prostate gland development, dorsal/ventral pattern formation, branching morphogenesis of an epithelial tube, lung lobe morphogenesis, embryonic forelimb morphogenesis, midbrain development, skin development, regulation of odontogenesis, regulation of mesenchymal cell proliferation involved in prostate gland development, mesenchymal cell proliferation involved in lung development, positive regulation of hh target transcription factor activity, prostate epithelial cord elongation, metanephric mesenchymal cell proliferation involved in metanephros development, endocytosis, lung morphogenesis, cell development, trachea morphogenesis, epithelial cell proliferation involved in salivary gland morphogenesis, cell-cell signaling, salivary gland cavitation, hindbrain development, blood coagulation, negative regulation of kidney smooth muscle cell differentiation, somite development, cerebellar granule cell precursor proliferation, axon guidance, negative regulation of ureter smooth muscle cell differentiation, positive regulation of ureter smooth muscle cell differentiation, multicellular organism development, animal organ formation, intein-mediated protein splicing, determination of left/right symmetry, vasculature development, positive regulation of gene expression, regulation of cell population proliferation, embryonic morphogenesis, neural crest cell migration, polarity specification of anterior/posterior axis, positive regulation of cell population proliferation, artery development, protein localization to nucleus, Bergmann glial cell differentiation, forebrain development, neuron fate commitment, CD4-positive or CD8-positive, alpha-beta T cell lineage commitment, striated muscle cell differentiation, myoblast differentiation, lung-associated mesenchyme development, epithelial tube branching involved in lung morphogenesis, positive regulation of cell division, positive regulation of transcription by RNA polymerase II, anterior/posterior pattern specification, embryonic hindlimb morphogenesis, forebrain regionalization, cell proliferation in external granule layer, tracheoesophageal septum formation, regulation of signaling receptor activity

Cell component cytosol, endoplasmic reticulum lumen, membrane, cell surface, membrane raft, plasma membrane, extracellular space, extracellular region, extracellular matrix

Encoded by SHH

Found in taxon Homo sapiens

Has part(s) Hint domain C-terminal, Hint domain N-terminal, Hedgehog, N-terminal signalling domain, Intein N-terminal splicing region, Hedgehog protein, Hint domain

Imported from wholeness_audit_2026-05-02

Molecular function calcium ion binding, metal ion binding, patched binding, peptidase activity, zinc ion binding, laminin-1 binding, glycosaminoglycan binding, morphogen activity, hydrolase activity, protein binding, endopeptidase activity

Named after Sonic the Hedgehog

External References (5)

Ensembl protein id ENSP00000297261, ENSP00000396621, ENSP00000410546, ENSP00000413871

Freebase id /m/01zlqs

Pdb structure id 3HO5, 3M1N, 3MXW

Refseq protein id NP_000184, NP_001297391, XP_011514781, XP_011514782

Uniprot protein id Upper Siang district

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Sonic hedgehog signaling molecule — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Sonic hedgehog signaling molecule — named after (P138): Sonic the Hedgehog. wikidata.org.
[4] ↑ Sonic hedgehog signaling molecule — UniProt protein ID (P352): Upper Siang district. Q905695. Retrieved 2019-11-13. wikidata.org.
[5] ↑ Sonic hedgehog signaling molecule — part of (P361): Hedgehog signalling/DD-peptidase zinc-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Sonic hedgehog signaling molecule — part of (P361): Hint domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Sonic hedgehog signaling molecule — part of (P361): hedgehog protein. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Sonic hedgehog signaling molecule — part of (P361): Hint domain N-terminal domain, protein family. wikidata.org.
[9] ↑ Sonic hedgehog signaling molecule — part of (P361): Hint domain C-terminal domain, protein family. wikidata.org.
[10] ↑ Sonic hedgehog signaling molecule — part of (P361): Hedgehog protein, Hint domain, protein family. wikidata.org.
[11] ↑ Sonic hedgehog signaling molecule — part of (P361): Hedgehog, N-terminal signalling domain, protein family. wikidata.org.
[12] ↑ Sonic hedgehog signaling molecule — Commons category (P373): Sonic hedgehog. wikidata.org.
[13] ↑ Sonic hedgehog signaling molecule — has part(s) (P527): Hint domain C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Sonic hedgehog signaling molecule — has part(s) (P527): Hint domain N-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Sonic hedgehog signaling molecule — has part(s) (P527): Hedgehog, N-terminal signalling domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Sonic hedgehog signaling molecule — has part(s) (P527): Intein N-terminal splicing region. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Sonic hedgehog signaling molecule — has part(s) (P527): Hedgehog protein, Hint domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Sonic hedgehog signaling molecule — RefSeq protein ID (P637): NP_000184. Q20641742. Retrieved 2020-05-30. wikidata.org.
[19] ↑ Sonic hedgehog signaling molecule — RefSeq protein ID (P637): NP_001297391. Q20641742. Retrieved 2020-05-30. wikidata.org.
[20] ↑ Sonic hedgehog signaling molecule — RefSeq protein ID (P637): XP_011514781. Q20641742. Retrieved 2020-05-30. wikidata.org.
[21] ↑ Sonic hedgehog signaling molecule — RefSeq protein ID (P637): XP_011514782. Q20641742. Retrieved 2020-05-30. wikidata.org.
[22] ↑ Sonic hedgehog signaling molecule — PDB structure ID (P638): 3HO5. Q905695. Retrieved 2016-08-09. wikidata.org.
[23] ↑ Sonic hedgehog signaling molecule — PDB structure ID (P638): 3M1N. Q905695. Retrieved 2016-08-09. wikidata.org.
[24] ↑ Sonic hedgehog signaling molecule — PDB structure ID (P638): 3MXW. Q905695. Retrieved 2016-08-09. wikidata.org.
[25] ↑ Sonic hedgehog signaling molecule — Freebase ID (P646): /m/01zlqs. Freebase Data Dumps. wikidata.org.
[26] ↑ Sonic hedgehog signaling molecule — molecular function (P680): calcium ion binding. The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling. Retrieved 2018-06-21. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Sonic hedgehog signaling molecule is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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BibTeX

@misc{4ortxyz_sonic-hedgehog-signaling-molecule-q2477760_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Sonic hedgehog signaling molecule}}, year = {2026}, url = {https://4ort.xyz/entity/sonic-hedgehog-signaling-molecule-q2477760}, note = {Accessed: 2026-05-03}}

LLM prompt

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Canonical URL: https://4ort.xyz/entity/sonic-hedgehog-signaling-molecule-q2477760 · Last refreshed: May 3, 2026