Sonic hedgehog

mammalian protein found in Mus musculus

Protein protein Q14860215

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Sonic hedgehog

Summary

Sonic hedgehog is a protein^[1].

Key Facts

Sonic hedgehog's instance of is recorded as protein^[2].
Sonic hedgehog's UniProt protein ID is recorded as Vyhurivshchyna-Troieshchyna^[3].
Sonic hedgehog's part of is recorded as Hedgehog signalling/DD-peptidase zinc-binding domain superfamily^[4].
Sonic hedgehog's part of is recorded as Hint domain superfamily^[5].
Sonic hedgehog's part of is recorded as hedgehog protein^[6].
Sonic hedgehog's part of is recorded as membrane protein^[7].
Sonic hedgehog's part of is recorded as Hint domain N-terminal domain, protein family^[8].
Sonic hedgehog's part of is recorded as Hint domain C-terminal domain, protein family^[9].
Sonic hedgehog's part of is recorded as Hedgehog protein, Hint domain, protein family^[10].
Sonic hedgehog's part of is recorded as Hedgehog, N-terminal signalling domain, protein family^[11].
Sonic hedgehog's has part is recorded as Intein N-terminal splicing region^[12].
Sonic hedgehog's has part is recorded as Hedgehog, N-terminal signalling domain^[13].
Sonic hedgehog's has part is recorded as Hint domain N-terminal^[14].
Sonic hedgehog's has part is recorded as Hint domain C-terminal^[15].
Sonic hedgehog's has part is recorded as Hedgehog protein, Hint domain^[16].
Sonic hedgehog's RefSeq protein ID is recorded as NP_033196^[17].
Sonic hedgehog's RefSeq protein ID is recorded as XP_006535711^[18].
Sonic hedgehog's RefSeq protein ID is recorded as XP_006535712^[19].
Sonic hedgehog's PDB structure ID is recorded as 1VHH^[20].
Sonic hedgehog's PDB structure ID is recorded as 2WFX^[21].
Sonic hedgehog's PDB structure ID is recorded as 2WG4^[22].
Sonic hedgehog's PDB structure ID is recorded as 3D1M^[23].
Sonic hedgehog's PDB structure ID is recorded as 3N1R^[24].
Sonic hedgehog's PDB structure ID is recorded as 4C4M^[25].
Sonic hedgehog's PDB structure ID is recorded as 4C4N^[26].

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Quick Facts

Instance of protein

Part of Hedgehog signalling/DD-peptidase zinc-binding domain superfamily, Hint domain superfamily, hedgehog protein, membrane protein, Hint domain N-terminal domain, protein family, Hint domain C-terminal domain, protein family, Hedgehog protein, Hint domain, protein family, Hedgehog, N-terminal signalling domain, protein family

Properties

Biological process positive regulation of skeletal muscle cell proliferation, pattern specification process, myotube differentiation, mesenchymal cell proliferation, male genitalia development, bud outgrowth involved in lung branching, limb bud formation, T cell differentiation in thymus, positive regulation of skeletal muscle tissue development, positive regulation of immature T cell proliferation in thymus, positive regulation of kidney smooth muscle cell differentiation, negative regulation of Wnt signaling pathway, anatomical structure formation involved in morphogenesis, ectoderm development, hindgut morphogenesis, spinal cord dorsal/ventral patterning, oligodendrocyte differentiation, formation of anatomical boundary, trachea development, prostate gland development, negative regulation of transcription elongation from RNA polymerase II promoter, limb development, vasculogenesis, primary prostatic bud elongation, heart looping, odontogenesis of dentin-containing tooth, positive regulation of mesenchymal cell proliferation, angiogenesis, positive regulation of epithelial cell proliferation involved in prostate gland development, positive regulation of striated muscle cell differentiation, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, embryonic digestive tract morphogenesis, apoptotic signaling pathway, inner ear development, hair follicle morphogenesis, cell population proliferation, metanephros development, lung epithelium development, vasculogenesis involved in coronary vascular morphogenesis, negative regulation of canonical Wnt signaling pathway, regulation of proteolysis, branching involved in salivary gland morphogenesis, negative regulation of mesenchymal cell apoptotic process, dopaminergic neuron differentiation, intermediate filament organization, renal system development, cell fate commitment, regulation of transcription, DNA-templated, positive regulation of smoothened signaling pathway, androgen metabolic process, kidney development, lung development, negative regulation of protein catabolic process, thymus development, embryonic organ development, negative regulation of cell differentiation, negative regulation of dopaminergic neuron differentiation, embryonic digit morphogenesis, negative regulation of alpha-beta T cell differentiation, epithelial-mesenchymal cell signaling, positive regulation of sclerotome development, negative regulation of gene expression, lymphoid progenitor cell differentiation, negative thymic T cell selection, positive regulation of transcription, DNA-templated, positive regulation of Wnt signaling pathway, central nervous system development, development of the heart, branching involved in ureteric bud morphogenesis, negative regulation of T cell proliferation, embryonic limb morphogenesis, positive regulation of cell differentiation, branching involved in prostate gland morphogenesis, establishment of cell polarity, positive regulation of mesenchymal cell proliferation involved in ureter development, branching involved in blood vessel morphogenesis, positive regulation of cerebellar granule cell precursor proliferation, neuroblast proliferation, pancreas development, positive regulation of protein import into nucleus, smoothened signaling pathway, oligodendrocyte development, camera-type eye development, spinal cord motor neuron differentiation, positive regulation of alpha-beta T cell differentiation, digestive tract morphogenesis, hair follicle development, positive regulation of oligodendrocyte differentiation, roof of mouth development, left lung development, striated muscle tissue development, positive regulation of T cell differentiation in thymus, cellular response to lithium ion, embryonic foregut morphogenesis, anatomical structure development, thalamus development, stem cell development, smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation, cell fate specification, negative regulation of transcription by RNA polymerase II, proteolysis, embryonic skeletal system development, regulation of protein localization to nucleus, odontogenesis, respiratory tube development, regulation of prostatic bud formation, thyroid gland development, negative regulation of cell migration, developmental growth, right lung development, determination of left/right asymmetry in lateral mesoderm, positive thymic T cell selection, mesenchymal smoothened signaling pathway involved in prostate gland development, regulation of gene expression, canonical Wnt signaling pathway, osteoblast development, negative regulation of cholesterol efflux, dorsal/ventral neural tube patterning, regulation of epithelial cell proliferation involved in prostate gland development, epithelial-mesenchymal signaling involved in prostate gland development, dorsal/ventral pattern formation, branching morphogenesis of an epithelial tube, lung lobe morphogenesis, embryonic forelimb morphogenesis, midbrain development, skin development, regulation of odontogenesis, regulation of mesenchymal cell proliferation involved in prostate gland development, ventral spinal cord interneuron specification, mesenchymal cell proliferation involved in lung development, positive regulation of hh target transcription factor activity, prostate epithelial cord elongation, metanephric mesenchymal cell proliferation involved in metanephros development, endocytosis, lung morphogenesis, cell development, trachea morphogenesis, epithelial cell proliferation involved in salivary gland morphogenesis, cell-cell signaling, salivary gland cavitation, hindbrain development, blood coagulation, negative regulation of kidney smooth muscle cell differentiation, somite development, cerebellar granule cell precursor proliferation, axon guidance, negative regulation of ureter smooth muscle cell differentiation, multicellular organism development, positive regulation of ureter smooth muscle cell differentiation, animal organ formation, intein-mediated protein splicing, determination of left/right symmetry, vasculature development, positive regulation of gene expression, embryonic morphogenesis, neural crest cell migration, polarity specification of anterior/posterior axis, positive regulation of cell population proliferation, artery development, protein localization to nucleus, Bergmann glial cell differentiation, forebrain development, neuron fate commitment, CD4-positive or CD8-positive, alpha-beta T cell lineage commitment, striated muscle cell differentiation, myoblast differentiation, lung-associated mesenchyme development, epithelial tube branching involved in lung morphogenesis, positive regulation of cell division, signal transduction, anterior/posterior pattern specification, positive regulation of transcription by RNA polymerase II, embryonic hindlimb morphogenesis, positive regulation of neuroblast proliferation, telencephalon regionalization, forebrain regionalization, cell proliferation in external granule layer, regulation of cell population proliferation, negative regulation of apoptotic process, neural tube formation, positive regulation of neuroblast proliferation, digestive tract mesoderm development, telencephalon regionalization, zona limitans intrathalamica formation, positive regulation of neurotrophin production, regulation of cell population proliferation, negative regulation of apoptotic process, tongue development, tongue morphogenesis, response to ethanol, positive regulation of neuron differentiation, positive regulation of photoreceptor cell differentiation, response to axon injury, male genitalia morphogenesis, positive regulation of penile erection, fungiform papilla development, fungiform papilla morphogenesis, fungiform papilla formation, positive regulation of oligodendrocyte progenitor proliferation, commissural neuron axon guidance, negative regulation of neuron death, positive regulation of sprouting angiogenesis, tracheoesophageal septum formation, positive regulation of endothelial cell chemotaxis, cell fate specification, smoothened signaling pathway, regulation of gene expression, oligodendrocyte differentiation

Cell component membrane, extracellular region, cell surface, plasma membrane, membrane raft, intracellular anatomical structure, extracellular space, extracellular region, nucleus, endoplasmic reticulum, Golgi apparatus, synaptic vesicle, transport vesicle, axon, dendrite, extracellular matrix, soma, membrane raft, extracellular space

Encoded by Shh

Expressed in zone of polarizing activity

Found in taxon house mouse

Has part(s) Intein N-terminal splicing region, Hedgehog, N-terminal signalling domain, Hint domain N-terminal, Hint domain C-terminal, Hedgehog protein, Hint domain

Imported from wholeness_audit_2026-05-02

Molecular function calcium ion binding, protein binding, metal ion binding, patched binding, zinc ion binding, laminin-1 binding, protein binding, glycosaminoglycan binding, hydrolase activity, protein binding, patched binding, calcium ion binding

External References (4)

Ensembl protein id ENSMUSP00000002708

Pdb structure id 1VHH, 2WFX, 2WG4, 3D1M, 3N1R, 4C4M, 4C4N

Refseq protein id NP_033196, XP_006535711, XP_006535712

Uniprot protein id Vyhurivshchyna-Troieshchyna

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Sonic hedgehog — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Sonic hedgehog — UniProt protein ID (P352): Vyhurivshchyna-Troieshchyna. Q905695. Retrieved 2022-05-25. wikidata.org.
[4] ↑ Sonic hedgehog — part of (P361): Hedgehog signalling/DD-peptidase zinc-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Sonic hedgehog — part of (P361): Hint domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Sonic hedgehog — part of (P361): hedgehog protein. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Sonic hedgehog — part of (P361): membrane protein. wikidata.org.
[8] ↑ Sonic hedgehog — part of (P361): Hint domain N-terminal domain, protein family. wikidata.org.
[9] ↑ Sonic hedgehog — part of (P361): Hint domain C-terminal domain, protein family. wikidata.org.
[10] ↑ Sonic hedgehog — part of (P361): Hedgehog protein, Hint domain, protein family. wikidata.org.
[11] ↑ Sonic hedgehog — part of (P361): Hedgehog, N-terminal signalling domain, protein family. wikidata.org.
[12] ↑ Sonic hedgehog — has part(s) (P527): Intein N-terminal splicing region. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Sonic hedgehog — has part(s) (P527): Hedgehog, N-terminal signalling domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Sonic hedgehog — has part(s) (P527): Hint domain N-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Sonic hedgehog — has part(s) (P527): Hint domain C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Sonic hedgehog — has part(s) (P527): Hedgehog protein, Hint domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Sonic hedgehog — RefSeq protein ID (P637): NP_033196. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ Sonic hedgehog — RefSeq protein ID (P637): XP_006535711. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ Sonic hedgehog — RefSeq protein ID (P637): XP_006535712. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ Sonic hedgehog — PDB structure ID (P638): 1VHH. Q905695. Retrieved 2016-08-09. wikidata.org.
[21] ↑ Sonic hedgehog — PDB structure ID (P638): 2WFX. Q905695. Retrieved 2016-08-09. wikidata.org.
[22] ↑ Sonic hedgehog — PDB structure ID (P638): 2WG4. Q905695. Retrieved 2016-08-09. wikidata.org.
[23] ↑ Sonic hedgehog — PDB structure ID (P638): 3D1M. Q905695. Retrieved 2016-08-09. wikidata.org.
[24] ↑ Sonic hedgehog — PDB structure ID (P638): 3N1R. Q905695. Retrieved 2016-08-09. wikidata.org.
[25] ↑ Sonic hedgehog — PDB structure ID (P638): 4C4M. Q905695. Retrieved 2016-08-09. wikidata.org.
[26] ↑ Sonic hedgehog — PDB structure ID (P638): 4C4N. Q905695. Retrieved 2016-08-09. wikidata.org.

Class ancestry

[1] ↑ Sonic hedgehog is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Sonic hedgehog. Retrieved May 3, 2026, from https://4ort.xyz/entity/sonic-hedgehog

MLA “Sonic hedgehog.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/sonic-hedgehog.

BibTeX

@misc{4ortxyz_sonic-hedgehog_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Sonic hedgehog}}, year = {2026}, url = {https://4ort.xyz/entity/sonic-hedgehog}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Sonic hedgehog — https://4ort.xyz/entity/sonic-hedgehog (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/sonic-hedgehog · Last refreshed: May 3, 2026