Home › Entities › protein › SMCR8-C9orf72 complex subunit

SMCR8-C9orf72 complex subunit

mammalian protein found in Homo sapiens
Protein protein Q21135644
Press Enter · cited answer in seconds

Summary

SMCR8-C9orf72 complex subunit is a protein[1].

Key Facts

  • SMCR8-C9orf72 complex subunit's instance of is recorded as protein[2].
  • SMCR8-C9orf72 complex subunit's subclass of is recorded as protein[3].
  • SMCR8-C9orf72 complex subunit's UniProt protein ID is recorded as Q8TEV9[4].
  • SMCR8-C9orf72 complex subunit's part of is recorded as Folliculin/SMCR8, N-terminal domain, protein family[5].
  • SMCR8-C9orf72 complex subunit's part of is recorded as Folliculin/SMCR8, tripartite DENN domain, protein family[6].
  • SMCR8-C9orf72 complex subunit's has part is recorded as Folliculin/SMCR8, N-terminal[7].
  • SMCR8-C9orf72 complex subunit's has part is recorded as Folliculin/SMCR8, tripartite DENN domain[8].
  • SMCR8-C9orf72 complex subunit's RefSeq protein ID is recorded as NP_658988[9].
  • SMCR8-C9orf72 complex subunit's molecular function is recorded as protein binding[10].
  • SMCR8-C9orf72 complex subunit's molecular function is recorded as protein kinase inhibitor activity[11].
  • SMCR8-C9orf72 complex subunit's molecular function is recorded as protein kinase binding[12].
  • SMCR8-C9orf72 complex subunit's molecular function is recorded as guanyl-nucleotide exchange factor activity[13].
  • SMCR8-C9orf72 complex subunit's cell component is recorded as nucleoplasm[14].
  • SMCR8-C9orf72 complex subunit's cell component is recorded as chromatin[15].
  • SMCR8-C9orf72 complex subunit's cell component is recorded as guanyl-nucleotide exchange factor complex[16].
  • SMCR8-C9orf72 complex subunit's cell component is recorded as Atg1/ULK1 kinase complex[17].
  • SMCR8-C9orf72 complex subunit's cell component is recorded as cytoplasm[18].
  • SMCR8-C9orf72 complex subunit's cell component is recorded as nucleus[19].
  • SMCR8-C9orf72 complex subunit's biological process is recorded as negative regulation of protein kinase activity[20].
  • SMCR8-C9orf72 complex subunit's biological process is recorded as negative regulation of gene expression[21].
  • SMCR8-C9orf72 complex subunit's biological process is recorded as negative regulation of macroautophagy[22].
  • SMCR8-C9orf72 complex subunit's biological process is recorded as positive regulation of TOR signaling[23].
  • SMCR8-C9orf72 complex subunit's biological process is recorded as positive regulation of autophagosome maturation[24].
  • SMCR8-C9orf72 complex subunit's biological process is recorded as negative regulation of autophagosome assembly[25].
  • SMCR8-C9orf72 complex subunit's biological process is recorded as regulation of autophagy[26].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . UniProt. Retrieved . wikidata.org.
  2. [3] ↑ . UniProt. Retrieved . wikidata.org.
  3. [4] ↑ . UniProt. Retrieved . wikidata.org.
  4. [5] ↑ . wikidata.org.
  5. [6] ↑ . wikidata.org.
  6. [7] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  7. [8] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  8. [9] ↑ . Q20641742. Retrieved . wikidata.org.
  9. [10] ↑ . C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [11] ↑ . Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [12] ↑ . Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [14] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [15] ↑ . Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [16] ↑ . Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [17] ↑ . The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [20] ↑ . Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [21] ↑ . Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [22] ↑ . Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [23] ↑ . Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [24] ↑ . Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [25] ↑ . Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [26] ↑ . Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). SMCR8-C9orf72 complex subunit. Retrieved May 3, 2026, from https://4ort.xyz/entity/smcr8-c9orf72-complex-subunit-q21135644
MLA “SMCR8-C9orf72 complex subunit.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/smcr8-c9orf72-complex-subunit-q21135644.
BibTeX @misc{4ortxyz_smcr8-c9orf72-complex-subunit-q21135644_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{SMCR8-C9orf72 complex subunit}}, year = {2026}, url = {https://4ort.xyz/entity/smcr8-c9orf72-complex-subunit-q21135644}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): SMCR8-C9orf72 complex subunit — https://4ort.xyz/entity/smcr8-c9orf72-complex-subunit-q21135644 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/smcr8-c9orf72-complex-subunit-q21135644 · Last refreshed: