SMAD family member 3

mammalian protein found in Homo sapiens

Protein protein Q6917575

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SMAD family member 3

Summary

SMAD family member 3 is a protein^[1].

Key Facts

SMAD family member 3's instance of is recorded as protein^[2].
SMAD family member 3's instance of is recorded as R-SMAD^[3].
SMAD family member 3's UniProt protein ID is recorded as P84022^[4].
SMAD family member 3's part of is recorded as SMAD-like domain superfamily^[5].
SMAD family member 3's part of is recorded as Dwarfin^[6].
SMAD family member 3's part of is recorded as SMAD MH1 domain superfamily^[7].
SMAD family member 3's part of is recorded as SMAD/FHA domain superfamily^[8].
SMAD family member 3's part of is recorded as MAD homology, MH1, protein family^[9].
SMAD family member 3's part of is recorded as SMAD domain, Dwarfin-type, protein family^[10].
SMAD family member 3's part of is recorded as MAD homology 1, Dwarfin-type, protein family^[11].
SMAD family member 3's MeSH descriptor ID is recorded as D051900^[12].
SMAD family member 3's has part is recorded as MAD homology 1, Dwarfin-type^[13].
SMAD family member 3's has part is recorded as SMAD domain, Dwarfin-type^[14].
SMAD family member 3's has part is recorded as MAD homology, MH1^[15].
SMAD family member 3's RefSeq protein ID is recorded as NP_001138574^[16].
SMAD family member 3's RefSeq protein ID is recorded as NP_001138575^[17].
SMAD family member 3's RefSeq protein ID is recorded as NP_001138576^[18].
SMAD family member 3's RefSeq protein ID is recorded as NP_005893^[19].
SMAD family member 3's RefSeq protein ID is recorded as XP_011519861^[20].
SMAD family member 3's RefSeq protein ID is recorded as XP_011519862^[21].
SMAD family member 3's PDB structure ID is recorded as 2LB2^[22].
SMAD family member 3's PDB structure ID is recorded as 1MHD^[23].
SMAD family member 3's PDB structure ID is recorded as 1MJS^[24].
SMAD family member 3's PDB structure ID is recorded as 1MK2^[25].
SMAD family member 3's PDB structure ID is recorded as 1OZJ^[26].

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Quick Facts

Instance of protein, R-SMAD

Part of SMAD-like domain superfamily, Dwarfin, SMAD MH1 domain superfamily, SMAD/FHA domain superfamily, MAD homology, MH1, protein family, SMAD domain, Dwarfin-type, protein family, MAD homology 1, Dwarfin-type, protein family

Properties

Biological process somitogenesis, skeletal system development, ureteric bud development, endoderm development, regulation of transforming growth factor beta2 production, embryonic pattern specification, regulation of transcription by RNA polymerase II, negative regulation of osteoblast differentiation, heart looping, positive regulation of chondrocyte differentiation, positive regulation of alkaline phosphatase activity, positive regulation of interleukin-1 beta production, pericardium development, regulation of binding, negative regulation of wound healing, activation of cysteine-type endopeptidase activity involved in apoptotic process, transforming growth factor beta receptor signaling pathway, negative regulation of inflammatory response, positive regulation of positive chemotaxis, negative regulation of cell population proliferation, negative regulation of fat cell differentiation, cell-cell junction organization, regulation of transcription, DNA-templated, extrinsic apoptotic signaling pathway, activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway, signal transduction involved in regulation of gene expression, in utero embryonic development, negative regulation of transforming growth factor beta receptor signaling pathway, nodal signaling pathway, positive regulation of transcription, DNA-templated, negative regulation of cell growth, regulation of immune response, positive regulation of transforming growth factor beta3 production, T cell activation, activin receptor signaling pathway, regulation of striated muscle tissue development, embryonic foregut morphogenesis, positive regulation of bone mineralization, wound healing, negative regulation of apoptotic process, positive regulation of extracellular matrix assembly, negative regulation of transcription by RNA polymerase II, positive regulation of epithelial to mesenchymal transition, mitigation of host defenses by virus, thyroid gland development, developmental growth, lens fiber cell differentiation, gastrulation, immune response, osteoblast differentiation, primary miRNA processing, negative regulation of osteoblast proliferation, osteoblast development, embryonic cranial skeleton morphogenesis, transdifferentiation, paraxial mesoderm morphogenesis, response to hypoxia, positive regulation of cell migration, mesoderm formation, regulation of transforming growth factor beta receptor signaling pathway, positive regulation of gene expression, immune system development, positive regulation of focal adhesion assembly, liver development, regulation of epithelial cell proliferation, positive regulation of stress fiber assembly, positive regulation of transcription by RNA polymerase II, negative regulation of mitotic cell cycle, negative regulation of cytosolic calcium ion concentration, canonical Wnt signaling pathway, protein stabilization, transcription, DNA-templated, negative regulation of protein catabolic process, protein deubiquitination, positive regulation of nitric oxide biosynthetic process, negative regulation of lung blood pressure, positive regulation of pri-miRNA transcription by RNA polymerase II, negative regulation of cardiac muscle hypertrophy in response to stress, cellular response to transforming growth factor beta stimulus, cellular response to cytokine stimulus, positive regulation of protein import into nucleus, positive regulation of DNA-binding transcription factor activity, SMAD protein signal transduction, positive regulation of canonical Wnt signaling pathway, SMAD protein complex assembly, adrenal gland development

Cell component cytoplasm, nucleus, heteromeric SMAD protein complex, SMAD protein complex, transcription regulator complex, receptor complex, plasma membrane, intracellular anatomical structure, nucleoplasm, nuclear inner membrane, cytosol, protein-containing complex

Encoded by SMAD3

Found in taxon Homo sapiens

Has part(s) MAD homology 1, Dwarfin-type, SMAD domain, Dwarfin-type, MAD homology, MH1

Imported from wholeness_audit_2026-05-02

Molecular function phosphatase binding, DNA-binding transcription factor activity, R-SMAD binding, co-SMAD binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, transcription factor binding, metal ion binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, enzyme binding, transforming growth factor beta receptor binding, protein homodimerization activity, collagen binding, zinc ion binding, chromatin binding, cis-regulatory region sequence-specific DNA binding, protein binding, double-stranded DNA binding, protein kinase binding, sequence-specific DNA binding, DNA binding, bHLH transcription factor binding, ubiquitin binding, identical protein binding, protein heterodimerization activity, chromatin DNA binding, ubiquitin protein ligase binding, beta-catenin binding, RNA polymerase II general transcription initiation factor activity, DEAD/H-box RNA helicase binding, mineralocorticoid receptor binding, glucocorticoid receptor binding, primary miRNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, SMAD binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription activator activity, RNA polymerase II-specific, transcription coregulator activity

External References (7)

Ensembl protein id ENSP00000445348, ENSP00000332973, ENSP00000401133, ENSP00000437757, ENSP00000452767, ENSP00000453082, ENSP00000453684, ENSP00000453788, ENSP00000454165, ENSP00000455095, ENSP00000455540, ENSP00000458060

Mesh descriptor id D051900

Mesh tree code D12.644.360.024.334.500.300, D12.776.157.057.170.500.300, D12.776.260.713.500.300, D12.776.476.024.428.500.300, D12.776.744.741.875, D12.776.930.806.500.300

Pdb structure id 2LB2, 1MHD, 1MJS, 1MK2, 1OZJ, 1U7F, 2LAJ, 5OD6, 5ODG

Refseq protein id NP_001138574, NP_001138575, NP_001138576, NP_005893, XP_011519861, XP_011519862

Umls cui C0529120

Uniprot protein id P84022

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ SMAD family member 3 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ SMAD family member 3 — instance of (P31): R-SMAD. wikidata.org.
[4] ↑ SMAD family member 3 — UniProt protein ID (P352): P84022. Q905695. Retrieved 2019-11-13. wikidata.org.
[5] ↑ SMAD family member 3 — part of (P361): SMAD-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ SMAD family member 3 — part of (P361): Dwarfin. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ SMAD family member 3 — part of (P361): SMAD MH1 domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ SMAD family member 3 — part of (P361): SMAD/FHA domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ SMAD family member 3 — part of (P361): MAD homology, MH1, protein family. wikidata.org.
[10] ↑ SMAD family member 3 — part of (P361): SMAD domain, Dwarfin-type, protein family. wikidata.org.
[11] ↑ SMAD family member 3 — part of (P361): MAD homology 1, Dwarfin-type, protein family. wikidata.org.
[12] ↑ SMAD family member 3 — MeSH descriptor ID (P486): D051900. wikidata.org.
[13] ↑ SMAD family member 3 — has part(s) (P527): MAD homology 1, Dwarfin-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ SMAD family member 3 — has part(s) (P527): SMAD domain, Dwarfin-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ SMAD family member 3 — has part(s) (P527): MAD homology, MH1. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ SMAD family member 3 — RefSeq protein ID (P637): NP_001138574. Q20641742. Retrieved 2020-05-30. wikidata.org.
[17] ↑ SMAD family member 3 — RefSeq protein ID (P637): NP_001138575. Q20641742. Retrieved 2020-05-30. wikidata.org.
[18] ↑ SMAD family member 3 — RefSeq protein ID (P637): NP_001138576. Q20641742. Retrieved 2020-05-30. wikidata.org.
[19] ↑ SMAD family member 3 — RefSeq protein ID (P637): NP_005893. Q20641742. Retrieved 2020-05-30. wikidata.org.
[20] ↑ SMAD family member 3 — RefSeq protein ID (P637): XP_011519861. Q20641742. Retrieved 2020-05-30. wikidata.org.
[21] ↑ SMAD family member 3 — RefSeq protein ID (P637): XP_011519862. Q20641742. Retrieved 2020-05-30. wikidata.org.
[22] ↑ SMAD family member 3 — PDB structure ID (P638): 2LB2. Q905695. Retrieved 2016-08-04. wikidata.org.
[23] ↑ SMAD family member 3 — PDB structure ID (P638): 1MHD. Q905695. Retrieved 2016-08-04. wikidata.org.
[24] ↑ SMAD family member 3 — PDB structure ID (P638): 1MJS. Q905695. Retrieved 2016-08-04. wikidata.org.
[25] ↑ SMAD family member 3 — PDB structure ID (P638): 1MK2. Q905695. Retrieved 2016-08-04. wikidata.org.
[26] ↑ SMAD family member 3 — PDB structure ID (P638): 1OZJ. Q905695. Retrieved 2016-08-04. wikidata.org.

Class ancestry

[1] ↑ SMAD family member 3 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). SMAD family member 3. Retrieved May 3, 2026, from https://4ort.xyz/entity/smad-family-member-3

MLA

“SMAD family member 3.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/smad-family-member-3.

BibTeX

@misc{4ortxyz_smad-family-member-3_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{SMAD family member 3}}, year = {2026}, url = {https://4ort.xyz/entity/smad-family-member-3}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): SMAD family member 3 — https://4ort.xyz/entity/smad-family-member-3 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/smad-family-member-3 · Last refreshed: May 3, 2026