SIX homeobox 2

mammalian protein found in Homo sapiens
Protein Protein Q21125207

Facts

8 properties
Instance of
protein
Part of
Homeobox-like domain superfamily, Homeobox domain, protein family, Homeobox protein SIX1, N-terminal SD domain, protein family, Homeobox, conserved site, protein family[2][3][4][5]
Biological process
embryonic skeletal system morphogenesis, regulation of chondrocyte differentiation, regulation of transcription, DNA-templated, positive regulation of chondrocyte proliferation, chondrocyte differentiation, protein import into nucleus, kidney development, negative regulation of cell differentiation, anatomical structure morphogenesis, mesenchymal stem cell maintenance involved in nephron morphogenesis, mesenchymal to epithelial transition involved in metanephros morphogenesis, mesenchymal cell differentiation involved in kidney development, mesenchymal stem cell proliferation, transcription by RNA polymerase II, regulation of branching involved in ureteric bud morphogenesis, multicellular organism development, nephron morphogenesis, nephron development, middle ear morphogenesis, embryonic digestive tract morphogenesis, embryonic cranial skeleton morphogenesis, regulation of ossification, cell population proliferation, mesodermal cell fate specification, anterior/posterior axis specification, metanephros development, cell migration, positive regulation of transcription by RNA polymerase II, condensed mesenchymal cell proliferation, kidney development, negative regulation of transcription, DNA-templated, anatomical structure development
Cell component
nucleus, nucleus, transcription regulator complex[21][22]
Encoded by
SIX2
Found in taxon
Homo sapiens
Has part(s)
Homeobox protein SIX1, N-terminal SD domain, Homeobox domain, Homeobox, conserved site[6][7][8]
Molecular function
DNA binding, sequence-specific DNA binding, DNA-binding transcription factor activity, DNA-binding transcription activator activity, RNA polymerase II-specific, transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein-containing complex binding, DNA-binding transcription factor activity, RNA polymerase II-specific, transcription cis-regulatory region binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific[9][10][11][12][13][14][15][16][17][18][19][20]
🏷️ Also known as
en homeobox protein SIX2 en sine oculis homeobox homolog 2 en SIX2 en SIX homeobox 2
🔖 Identifiers · 3
Ensembl protein ID
ENSP00000304502
RefSeq protein ID
NP_058628, XP_005264157
UniProt protein ID
Q9NPC8

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Summary

SIX homeobox 2 is a protein[1].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [3] ↑ . wikidata.org.
  3. [4] ↑ . wikidata.org.
  4. [5] ↑ . wikidata.org.
  5. [6] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [7] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  7. [8] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  8. [9] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [10] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [11] ↑ . Structure, mapping and expression of the human gene encoding the homeodomain protein, SIX2. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [12] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [14] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [16] ↑ . A census of human transcription factors: function, expression and evolution. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [17] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [18] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [20] ↑ . A census of human transcription factors: function, expression and evolution. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [21] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). SIX homeobox 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/six-homeobox-2
MLA “SIX homeobox 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/six-homeobox-2.
BibTeX @misc{4ortxyz_six-homeobox-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{SIX homeobox 2}}, year = {2026}, url = {https://4ort.xyz/entity/six-homeobox-2}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): SIX homeobox 2 — https://4ort.xyz/entity/six-homeobox-2 (retrieved 2026-05-03)

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