Sirtuin 2

mammalian protein found in Homo sapiens

Protein protein Q21108304

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Sirtuin 2

Summary

Sirtuin 2 is a protein^[1]. It is known by 9 alternative names across languages and contexts.^[2]

Key Facts

Sirtuin 2's instance of is recorded as protein^[3].
Sirtuin 2 is part of DHS-like NAD/FAD-binding domain superfamily^[4].
Sirtuin 2 is part of Sirtuin, class I^[5].
Sirtuin 2 is part of Sirtuin, catalytic core small domain superfamily^[6].
Sirtuin 2 is part of Sirtuin family, catalytic core domain, protein family^[7].
Sirtuin 2 comprises Sirtuin family, catalytic core domain^[8].
Sirtuin 2's molecular function is recorded as histone deacetylase binding^[9].
Sirtuin 2's molecular function is recorded as transcription factor binding^[10].
Sirtuin 2's molecular function is recorded as metal ion binding^[11].
Sirtuin 2's molecular function is recorded as protein deacetylase activity^[12].
Sirtuin 2's molecular function is recorded as zinc ion binding^[13].
Sirtuin 2's molecular function is recorded as chromatin binding^[14].
Sirtuin 2's molecular function is recorded as protein binding^[15].
Sirtuin 2's molecular function is recorded as histone acetyltransferase binding^[16].
Sirtuin 2's molecular function is recorded as tubulin deacetylase activity^[17].
Sirtuin 2's molecular function is recorded as NAD-dependent histone deacetylase activity (H4-K16 specific)^[18].
Sirtuin 2's molecular function is recorded as NAD-dependent protein deacetylase activity^[19].
Sirtuin 2's molecular function is recorded as histone deacetylase activity^[20].
Sirtuin 2's molecular function is recorded as ubiquitin binding^[21].
Sirtuin 2's molecular function is recorded as NAD+ binding^[22].
Sirtuin 2's molecular function is recorded as beta-tubulin binding^[23].
Sirtuin 2's molecular function is recorded as NAD+ ADP-ribosyltransferase activity^[24].
Sirtuin 2's molecular function is recorded as hydrolase activity^[25].
Sirtuin 2's molecular function is recorded as NAD-dependent histone deacetylase activity^[26].
Sirtuin 2's molecular function is recorded as transcription factor binding^[27].

Why It Matters

Sirtuin 2 is known by 9 alternative names across languages and contexts.^[2]

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Quick Facts

Instance of protein

Part of DHS-like NAD/FAD-binding domain superfamily, Sirtuin, class I, Sirtuin, catalytic core small domain superfamily, Sirtuin family, catalytic core domain, protein family

Properties

Biological process cellular response to molecule of bacterial origin, positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia, cellular response to epinephrine stimulus, tubulin deacetylation, rDNA heterochromatin assembly, phosphatidylinositol 3-kinase signaling, cell cycle, positive regulation of DNA binding, negative regulation of autophagy, cellular response to hypoxia, negative regulation of cell population proliferation, proteasome-mediated ubiquitin-dependent protein catabolic process, cellular lipid catabolic process, histone H3 deacetylation, peptidyl-lysine deacetylation, negative regulation of fat cell differentiation, regulation of transcription, DNA-templated, substantia nigra development, negative regulation of protein catabolic process, negative regulation of NLRP3 inflammasome complex assembly, negative regulation of oligodendrocyte progenitor proliferation, regulation of fat cell differentiation, transcription, DNA-templated, myelination in peripheral nervous system, histone H4 deacetylation, regulation of myelination, innate immune response, hepatocyte growth factor receptor signaling pathway, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, regulation of exit from mitosis, cell differentiation, protein ADP-ribosylation, immune system process, cellular response to hepatocyte growth factor stimulus, negative regulation of peptidyl-threonine phosphorylation, regulation of phosphorylation, negative regulation of transcription by RNA polymerase II, nervous system development, response to redox state, protein deacetylation, positive regulation of attachment of spindle microtubules to kinetochore, meiosis, cellular response to caloric restriction, ripoptosome assembly involved in necroptotic process, negative regulation of transcription from RNA polymerase II promoter in response to hypoxia, negative regulation of transcription, DNA-templated, negative regulation of defense response to bacterium, positive regulation of execution phase of apoptosis, protein kinase B signaling, negative regulation of striated muscle tissue development, positive regulation of oocyte maturation, regulation of cell cycle, cell division, autophagy, positive regulation of meiotic nuclear division, cellular response to oxidative stress, negative regulation of reactive oxygen species metabolic process, histone deacetylation, positive regulation of cell division, positive regulation of transcription by RNA polymerase II, histone deacetylation, substantia nigra development

Cell component cytoplasm, cytosol, membrane, microtubule organizing center, chromatin silencing complex, perinuclear region of cytoplasm, paranode region of axon, microtubule, cytoskeleton, nucleus, centrosome, cell projection, myelin sheath, glial cell projection, Schmidt-Lanterman incisure, paranodal junction, perikaryon, growth cone, spindle, chromosome, lateral loop, mitotic spindle, meiotic spindle, midbody, centriole, juxtaparanode region of axon, telomere, nucleolus, mitochondrion, plasma membrane

Ec enzyme number 2.3.1.286

Encoded by SIRT2

Found in taxon Homo sapiens

Has part(s) Sirtuin family, catalytic core domain

Molecular function histone deacetylase binding, transcription factor binding, metal ion binding, protein deacetylase activity, zinc ion binding, chromatin binding, protein binding, histone acetyltransferase binding, tubulin deacetylase activity, NAD-dependent histone deacetylase activity (H4-K16 specific), NAD-dependent protein deacetylase activity, histone deacetylase activity, ubiquitin binding, NAD+ binding, beta-tubulin binding, NAD+ ADP-ribosyltransferase activity, hydrolase activity, NAD-dependent histone deacetylase activity, transcription factor binding, NAD-dependent histone deacetylase activity, NAD+ binding

External References (7)

Ensembl protein id ENSP00000249396, ENSP00000375931, ENSP00000489602, ENSP00000488940, ENSP00000351809, ENSP00000400338, ENSP00000408023, ENSP00000489495, ENSP00000404309, ENSP00000489332, ENSP00000385146, ENSP00000407272, ENSP00000401203, ENSP00000409690, ENSP00000489481, ENSP00000489238, ENSP00000411393, ENSP00000489066, ENSP00000489360, ENSP00000397022, ENSP00000481932, ENSP00000488998, ENSP00000489426, ENSP00000489070, ENSP00000489020, ENSP00000489036

Mesh descriptor id D056565

Mesh tree code D08.811.277.087.520.200.650.200, D08.811.913.400.725.115.961.200, D12.776.476.900.200

Pdb structure id 1J8F, 3ZGO, 3ZGV, 4L3O, 4R8M, 4RMG, 4RMH, 4RMI, 4RMJ, 4Y6O, 5DY4, 5D7O, 5DY5, 4Y6L, 4Y6Q, 4X3O, 4X3P, 5D7P, 5D7Q, 5FYQ

Refseq protein id NP_001180215, NP_036369, NP_085096, XP_006723174, XP_011524956, XP_011524957, XP_016881989

Umls cui C2720168

Uniprot protein id Q8IXJ6

🏷️ Also known as

en NAD-dependent deacetylase sirtuin-2 en NAD-dependent protein deacetylase sirtuin-2 en regulatory protein SIR2 homolog 2 en silent information regulator 2 en SIR2-like protein 2 en sir2-related protein type 2 en SIRT2 en Sirtuin 2 en sirtuin type 2

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Sirtuin 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/sirtuin-2-q21108304

MLA “Sirtuin 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/sirtuin-2-q21108304.

BibTeX

@misc{4ortxyz_sirtuin-2-q21108304_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Sirtuin 2}}, year = {2026}, url = {https://4ort.xyz/entity/sirtuin-2-q21108304}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Sirtuin 2 — https://4ort.xyz/entity/sirtuin-2-q21108304 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/sirtuin-2-q21108304 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

8w ago · Boghog · 2026-07-24 view diff on Wikidata ↗

Found in taxon → Homo sapiens

Mesh tree code → D08.811.277.087.520.200.650.200, D08.811.913.400.725.115.961.200, D12.776.476.900.200

Wikidata description → mammalian protein found in Homo sapiens

Pdb structure id → 1J8F, 3ZGO, 3ZGV +17

+ 14 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.3.1.286, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"

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Sirtuin 2

Sirtuin 2

Summary

Key Facts

Why It Matters

References

Direct Wikidata claims

Class ancestry

Aggregate / graph-position facts

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