sirtuin 1

mammalian protein found in Homo sapiens
Protein protein Q21113719
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sirtuin 1

Summary

sirtuin 1 is a protein[1]. It has Wikipedia articles in 11 language editions, a strong signal of global cultural recognition.[2]

Key Facts

  • sirtuin 1's instance of is recorded as protein[3].
  • sirtuin 1's physically interacts with is recorded as SRT-1720[4].
  • sirtuin 1 is part of sirtuin family[5].
  • sirtuin 1 is part of DHS-like NAD/FAD-binding domain superfamily[6].
  • sirtuin 1 is part of Sirtuin, catalytic core small domain superfamily[7].
  • sirtuin 1 is part of Sirtuin family, catalytic core domain, protein family[8].
  • sirtuin 1 comprises Sirtuin family, catalytic core domain[9].
  • sirtuin 1's molecular function is recorded as transcription corepressor activity[10].
  • sirtuin 1's molecular function is recorded as protein domain specific binding[11].
  • sirtuin 1's molecular function is recorded as core promoter sequence-specific DNA binding[12].
  • sirtuin 1's molecular function is recorded as protein C-terminus binding[13].
  • sirtuin 1's molecular function is recorded as keratin filament binding[14].
  • sirtuin 1's molecular function is recorded as transcription factor binding[15].
  • sirtuin 1's molecular function is recorded as metal ion binding[16].
  • sirtuin 1's molecular function is recorded as HLH domain binding[17].
  • sirtuin 1's molecular function is recorded as enzyme binding[18].
  • sirtuin 1's molecular function is recorded as protein deacetylase activity[19].
  • sirtuin 1's molecular function is recorded as histone binding[20].
  • sirtuin 1's molecular function is recorded as protein binding[21].
  • sirtuin 1's molecular function is recorded as NAD-dependent histone deacetylase activity[22].
  • sirtuin 1's molecular function is recorded as NAD-dependent protein deacetylase activity[23].
  • sirtuin 1's molecular function is recorded as histone deacetylase activity[24].
  • sirtuin 1's molecular function is recorded as p53 binding[25].
  • sirtuin 1's molecular function is recorded as mitogen-activated protein kinase binding[26].
  • sirtuin 1's molecular function is recorded as deacetylase activity[27].

Why It Matters

sirtuin 1 has Wikipedia articles in 11 language editions, a strong signal of global cultural recognition.[2] It is known by 8 alternative names across languages and contexts.[28]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] . Q905695. Retrieved . wikidata.org.
  2. [4] . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  3. [5] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [6] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  5. [7] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [8] . wikidata.org.
  7. [9] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  8. [10] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [11] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [12] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [13] . Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [14] . A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [15] . A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] . Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] . A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] . SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] . Dynamic distribution of linker histone H1.5 in cellular differentiation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] . CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] . JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] . hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] . JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] . Wikidata sitelinks. wikidata.org.
  2. [28] . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). sirtuin 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/sirtuin-1
MLA “sirtuin 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/sirtuin-1.
BibTeX @misc{4ortxyz_sirtuin-1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{sirtuin 1}}, year = {2026}, url = {https://4ort.xyz/entity/sirtuin-1}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): sirtuin 1 — https://4ort.xyz/entity/sirtuin-1 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/sirtuin-1 · Last refreshed:

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 27d ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Found in taxon Homo sapiens
    Physically interacts with SRT-1720
    Instance of
    Encoded by SIRT1
    + 10 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.3.1.286, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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