SH3 domain containing ring finger 2

mammalian protein found in Homo sapiens
Protein protein Q21100407
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Summary

SH3 domain containing ring finger 2 is a protein[1]. It is known by 12 alternative names across languages and contexts.[2]

Key Facts

  • Part of: SH3-like domain superfamily[3], E3 ubiquitin-protein ligase SH3RF2[4], Zinc finger, RING/FYVE/PHD-type[5], RING-type zinc-finger, LisH dimerisation motif, protein family[6], E3 ubiquitin-protein ligase SH3RF2, first SH3 domain, protein family[7], E3 ubiquitin-protein ligase SH3RF2, second SH3 domain, protein family[8], Zinc finger, RING-type, protein family[9], SH3RF2, third SH3 domain, protein family[10], SH3 domain, protein family[11], Zinc finger, RING-type, conserved site, protein family[12]
  • Has part(s): Zinc finger, RING-type, conserved site[13], SH3 domain[14], Zinc finger, RING-type[15], RING-type zinc-finger, LisH dimerisation motif[16], E3 ubiquitin-protein ligase SH3RF2, second SH3 domain[17], SH3RF2, third SH3 domain[18], E3 ubiquitin-protein ligase SH3RF2, first SH3 domain[19]
  • Molecular function: protein phosphatase inhibitor activity[20], protein phosphatase 1 binding[21], phosphatase binding[22], protein binding[23], metal ion binding[24], transferase activity[25], ubiquitin protein ligase activity[26]
  • Cell component: nucleoplasm[27], nucleus[28]
  • Biological process: negative regulation of phosphatase activity[29], protein ubiquitination[30], negative regulation of phosphoprotein phosphatase activity[31], positive regulation of cell migration[32], negative regulation of protein ubiquitination[33], positive regulation of proteasomal ubiquitin-dependent protein catabolic process[34], negative regulation of apoptotic process[35], negative regulation of JNK cascade[36], positive regulation of JNK cascade[37], protein autoubiquitination[38], regulation of JNK cascade[39]
  • Encoded by: SH3RF2[40]
  • Found in taxon: Homo sapiens[41]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [5] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [6] ↑ . wikidata.org.
  5. [7] ↑ . wikidata.org.
  6. [8] ↑ . wikidata.org.
  7. [9] ↑ . wikidata.org.
  8. [10] ↑ . wikidata.org.
  9. [11] ↑ . wikidata.org.
  10. [12] ↑ . wikidata.org.
  11. [13] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  12. [14] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  13. [15] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  14. [16] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  15. [17] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  16. [18] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  17. [19] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  18. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] ↑ . FLJ23654 encodes a heart protein phosphatase 1-binding protein (Hepp1). Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] ↑ . Docking motif-guided mapping of the interactome of protein phosphatase-1. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] ↑ . SH3RF2 functions as an oncogene by mediating PAK4 protein stability. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] ↑ . SH3RF2 functions as an oncogene by mediating PAK4 protein stability. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [28] ↑ . SH3RF2 functions as an oncogene by mediating PAK4 protein stability. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [29] ↑ . Docking motif-guided mapping of the interactome of protein phosphatase-1. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [30] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [31] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  30. [32] ↑ . SH3RF2 functions as an oncogene by mediating PAK4 protein stability. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  31. [33] ↑ . SH3RF2 functions as an oncogene by mediating PAK4 protein stability. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  32. [34] ↑ . Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein.. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  33. [35] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  34. [36] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  35. [37] ↑ . SH3RF2 functions as an oncogene by mediating PAK4 protein stability. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  36. [38] ↑ . SH3RF2 functions as an oncogene by mediating PAK4 protein stability. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  37. [39] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  38. [40] ↑ . UniProt. Retrieved . wikidata.org.
  39. [41] ↑ . UniProt. Retrieved . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). SH3 domain containing ring finger 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/sh3-domain-containing-ring-finger-2-q21100407
MLA “SH3 domain containing ring finger 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/sh3-domain-containing-ring-finger-2-q21100407.
BibTeX @misc{4ortxyz_sh3-domain-containing-ring-finger-2-q21100407_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{SH3 domain containing ring finger 2}}, year = {2026}, url = {https://4ort.xyz/entity/sh3-domain-containing-ring-finger-2-q21100407}, note = {Accessed: 2026-05-03}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 12w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from → —
    Encoded by → SH3RF2
    Wikidata description → mammalian protein found in Homo sapiens
    Molecular function → protein phosphatase inhibitor activity, protein phosphatase 1 binding, phosphatase binding +6
    + 10 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 2.3.2.27, [[:toollabs:quickstatements/#/batch/261488|batch #261488]]"
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