SET domain containing 2

mammalian protein found in Mus musculus

Protein protein Q21988099

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SET domain containing 2

Summary

SET domain containing 2 is a protein^[1].

Key Facts

SET domain containing 2's instance of is recorded as protein^[2].
SET domain containing 2's subclass of is recorded as protein^[3].
SET domain containing 2's UniProt protein ID is recorded as E9Q5F9^[4].
SET domain containing 2's part of is recorded as WW domain superfamily^[5].
SET domain containing 2's part of is recorded as TFIIS/LEDGF domain superfamily^[6].
SET domain containing 2's part of is recorded as Set2 Rpb1 interacting domain superfamily^[7].
SET domain containing 2's part of is recorded as Post-SET domain, protein family^[8].
SET domain containing 2's part of is recorded as Set2 Rpb1 interacting domain, protein family^[9].
SET domain containing 2's part of is recorded as SET domain, protein family^[10].
SET domain containing 2's part of is recorded as WW domain, protein family^[11].
SET domain containing 2's part of is recorded as AWS domain, protein family^[12].
SET domain containing 2's has part is recorded as AWS domain^[13].
SET domain containing 2's has part is recorded as Set2 Rpb1 interacting domain^[14].
SET domain containing 2's has part is recorded as WW domain^[15].
SET domain containing 2's has part is recorded as SET domain^[16].
SET domain containing 2's has part is recorded as Post-SET domain^[17].
SET domain containing 2's RefSeq protein ID is recorded as NP_001074809^[18].
SET domain containing 2's RefSeq protein ID is recorded as XP_006512151^[19].
SET domain containing 2's RefSeq protein ID is recorded as XP_006512154^[20].
SET domain containing 2's RefSeq protein ID is recorded as XP_006512155^[21].
SET domain containing 2's RefSeq protein ID is recorded as XP_036010808^[22].
SET domain containing 2's RefSeq protein ID is recorded as XP_036010809^[23].
SET domain containing 2's RefSeq protein ID is recorded as XP_036010810^[24].
SET domain containing 2's RefSeq protein ID is recorded as XP_036010811^[25].
SET domain containing 2's molecular function is recorded as methyltransferase activity^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of WW domain superfamily, TFIIS/LEDGF domain superfamily, Set2 Rpb1 interacting domain superfamily, Post-SET domain, protein family, Set2 Rpb1 interacting domain, protein family, SET domain, protein family, WW domain, protein family, AWS domain, protein family

Properties

Biological process regulation of transcription, DNA-templated, histone H3-K36 dimethylation, regulation of mRNA export from nucleus, embryonic organ development, stem cell development, embryonic placenta morphogenesis, transcription elongation from RNA polymerase II promoter, coronary vasculature morphogenesis, cell migration involved in vasculogenesis, morphogenesis of a branching structure, transcription, DNA-templated, vasculogenesis, histone H3-K36 methylation, mesoderm morphogenesis, methylation, neural tube closure, nucleosome organization, angiogenesis, pericardium development, regulation of gene expression, histone H3-K36 trimethylation, embryonic cranial skeleton morphogenesis, DNA mismatch repair, histone lysine methylation, forebrain development, endodermal cell differentiation, stem cell differentiation, regulation of double-strand break repair via homologous recombination, peptidyl-lysine trimethylation, peptidyl-lysine monomethylation, regulation of cytokinesis, positive regulation of interferon-alpha production, response to type I interferon, defense response to virus, microtubule cytoskeleton organization involved in mitosis, regulation of protein localization to chromatin, immune system process, DNA repair, cellular response to DNA damage stimulus, multicellular organism development, cell differentiation, innate immune response, chromatin organization

Cell component nucleus, chromosome

Encoded by Setd2

Found in taxon house mouse

Has part(s) AWS domain, Set2 Rpb1 interacting domain, WW domain, SET domain, Post-SET domain

Imported from wholeness_audit_2026-05-02

Molecular function methyltransferase activity, transferase activity, histone-lysine N-methyltransferase activity, histone methyltransferase activity (H3-K36 specific), protein-lysine N-methyltransferase activity, alpha-tubulin binding, metal ion binding

External References (3)

Ensembl protein id ENSMUSP00000116313, ENSMUSP00000142553, ENSMUSP00000142572, ENSMUSP00000142933, ENSMUSP00000142960, ENSMUSP00000143774

Refseq protein id NP_001074809, XP_006512151, XP_006512154, XP_006512155, XP_036010808, XP_036010809, XP_036010810, XP_036010811

Uniprot protein id E9Q5F9

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ SET domain containing 2 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ SET domain containing 2 — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ SET domain containing 2 — UniProt protein ID (P352): E9Q5F9. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ SET domain containing 2 — part of (P361): WW domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ SET domain containing 2 — part of (P361): TFIIS/LEDGF domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ SET domain containing 2 — part of (P361): Set2 Rpb1 interacting domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ SET domain containing 2 — part of (P361): Post-SET domain, protein family. wikidata.org.
[9] ↑ SET domain containing 2 — part of (P361): Set2 Rpb1 interacting domain, protein family. wikidata.org.
[10] ↑ SET domain containing 2 — part of (P361): SET domain, protein family. wikidata.org.
[11] ↑ SET domain containing 2 — part of (P361): WW domain, protein family. wikidata.org.
[12] ↑ SET domain containing 2 — part of (P361): AWS domain, protein family. wikidata.org.
[13] ↑ SET domain containing 2 — has part(s) (P527): AWS domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ SET domain containing 2 — has part(s) (P527): Set2 Rpb1 interacting domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ SET domain containing 2 — has part(s) (P527): WW domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ SET domain containing 2 — has part(s) (P527): SET domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ SET domain containing 2 — has part(s) (P527): Post-SET domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ SET domain containing 2 — RefSeq protein ID (P637): NP_001074809. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ SET domain containing 2 — RefSeq protein ID (P637): XP_006512151. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ SET domain containing 2 — RefSeq protein ID (P637): XP_006512154. Q20641742. Retrieved 2022-03-20. wikidata.org.
[21] ↑ SET domain containing 2 — RefSeq protein ID (P637): XP_006512155. Q20641742. Retrieved 2022-03-20. wikidata.org.
[22] ↑ SET domain containing 2 — RefSeq protein ID (P637): XP_036010808. Q20641742. Retrieved 2022-03-20. wikidata.org.
[23] ↑ SET domain containing 2 — RefSeq protein ID (P637): XP_036010809. Q20641742. Retrieved 2022-03-20. wikidata.org.
[24] ↑ SET domain containing 2 — RefSeq protein ID (P637): XP_036010810. Q20641742. Retrieved 2022-03-20. wikidata.org.
[25] ↑ SET domain containing 2 — RefSeq protein ID (P637): XP_036010811. Q20641742. Retrieved 2022-03-20. wikidata.org.
[26] ↑ SET domain containing 2 — molecular function (P680): methyltransferase activity. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ SET domain containing 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). SET domain containing 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/set-domain-containing-2

MLA

“SET domain containing 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/set-domain-containing-2.

BibTeX

@misc{4ortxyz_set-domain-containing-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{SET domain containing 2}}, year = {2026}, url = {https://4ort.xyz/entity/set-domain-containing-2}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): SET domain containing 2 — https://4ort.xyz/entity/set-domain-containing-2 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/set-domain-containing-2 · Last refreshed: May 3, 2026