Sestrin 2

mammalian protein found in Homo sapiens
Protein protein Q21125178
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Sestrin 2

Summary

Sestrin 2 is a protein[1].

Key Facts

  • Sestrin 2's instance of is recorded as protein[2].
  • Sestrin 2's UniProt protein ID is recorded as P58004[3].
  • Sestrin 2's part of is recorded as AhpD-like[4].
  • Sestrin 2's part of is recorded as sestrin[5].
  • Sestrin 2's RefSeq protein ID is recorded as NP_113647[6].
  • Sestrin 2's PDB structure ID is recorded as 5DJ4[7].
  • Sestrin 2's PDB structure ID is recorded as 5CUF[8].
  • Sestrin 2's molecular function is recorded as protein binding[9].
  • Sestrin 2's molecular function is recorded as oxidoreductase activity, acting on peroxide as acceptor[10].
  • Sestrin 2's molecular function is recorded as leucine binding[11].
  • Sestrin 2's molecular function is recorded as sulfiredoxin activity[12].
  • Sestrin 2's molecular function is recorded as oxidoreductase activity[13].
  • Sestrin 2's molecular function is recorded as GDP-dissociation inhibitor activity[14].
  • Sestrin 2's molecular function is recorded as oxidoreductase activity, acting on peroxide as acceptor[15].
  • Sestrin 2's molecular function is recorded as leucine binding[16].
  • Sestrin 2's cell component is recorded as nucleus[17].
  • Sestrin 2's cell component is recorded as mitochondrion[18].
  • Sestrin 2's cell component is recorded as cytosol[19].
  • Sestrin 2's cell component is recorded as cytoplasm[20].
  • Sestrin 2's cell component is recorded as GATOR2 complex[21].
  • Sestrin 2's cell component is recorded as nucleotide-activated protein kinase complex[22].
  • Sestrin 2's cell component is recorded as Atg1/ULK1 kinase complex[23].
  • Sestrin 2's cell component is recorded as TORC2 complex[24].
  • Sestrin 2's cell component is recorded as cytoplasm[25].
  • Sestrin 2's cell component is recorded as TORC2 complex[26].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] . Q905695. Retrieved . wikidata.org.
  2. [3] . Q905695. Retrieved . wikidata.org.
  3. [4] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [5] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  5. [6] . Q20641742. Retrieved . wikidata.org.
  6. [7] . Q905695. Retrieved . wikidata.org.
  7. [8] . Q905695. Retrieved . wikidata.org.
  8. [9] . p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [10] . Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [11] . Sestrin2 is a leucine sensor for the mTORC1 pathway. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [12] . Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [13] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [14] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [15] . Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [16] . Sestrin2 is a leucine sensor for the mTORC1 pathway. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [17] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [18] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [19] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [20] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [21] . Sestrin2 is a leucine sensor for the mTORC1 pathway. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [22] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [23] . Sestrin2 promotes Unc‐51‐like kinase 1 mediated phosphorylation of p62/sequestosome‐1. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [24] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [25] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [26] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Sestrin 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/sestrin-2
MLA “Sestrin 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/sestrin-2.
BibTeX @misc{4ortxyz_sestrin-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Sestrin 2}}, year = {2026}, url = {https://4ort.xyz/entity/sestrin-2}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Sestrin 2 — https://4ort.xyz/entity/sestrin-2 (retrieved 2026-05-03)

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