Senataxin

mammalian protein found in Homo sapiens
Protein protein Q21124479
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Summary

Senataxin is a protein[1]. Senataxin is known by 5 alternative names across languages and contexts.[2]

Key Facts

  • Part of: P-loop containing nucleoside triphosphate hydrolase[3]
  • EC enzyme number: 5.6.2.3[4]
  • Molecular function: transcription termination site sequence-specific DNA binding[5], nucleotide binding[6], protein binding[7], ATP binding[8], helicase activity[9], DNA helicase activity[10], identical protein binding[11], hydrolase activity[12], DNA binding[13], RNA binding[14]
  • Cell component: nucleolus[15], telomere[16], nuclear chromosome[17], chromosome[18], cell projection[19], cytoplasm[20], growth cone[21], nucleoplasm[22], axon[23], nucleus[24], nuclear body[25], intercellular bridge[26]
  • Biological process: cellular response to fibroblast growth factor stimulus[27], positive regulation of DNA-templated transcription, termination[28], fibroblast growth factor receptor signaling pathway[29], positive regulation of RNA splicing[30], DNA recombination[31], cellular response to retinoic acid[32], nervous system development[33], positive regulation of neuron projection development[34], DNA repair[35], RNA processing[36], termination of RNA polymerase II transcription[37], cell differentiation[38], DNA-templated transcription, termination[39], mRNA splice site selection[40]
  • Encoded by: SETX[41]
  • Found in taxon: Homo sapiens[42]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [4] ↑ . UniProt. Retrieved . wikidata.org.
  3. [5] ↑ . Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  4. [6] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  5. [7] ↑ . Functional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  6. [8] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  7. [9] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [10] ↑ . Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [11] ↑ . Protein interaction analysis of senataxin and the ALS4 L389S mutant yields insights into senataxin post-translational modification and uncovers mutant-specific binding with a brain cytoplasmic RNA-encoded peptide. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [12] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [13] ↑ . Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [14] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] ↑ . A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] ↑ . Senataxin modulates neurite growth through fibroblast growth factor 8 signalling. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [28] ↑ . Functional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [29] ↑ . Senataxin modulates neurite growth through fibroblast growth factor 8 signalling. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [30] ↑ . Functional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [31] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  30. [32] ↑ . Senataxin modulates neurite growth through fibroblast growth factor 8 signalling. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  31. [33] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  32. [34] ↑ . Senataxin modulates neurite growth through fibroblast growth factor 8 signalling. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  33. [35] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  34. [36] ↑ . Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  35. [37] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  36. [38] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  37. [39] ↑ . SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  38. [40] ↑ . Functional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  39. [41] ↑ . UniProt. Retrieved . wikidata.org.
  40. [42] ↑ . UniProt. Retrieved . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikidata aliases. wikidata.org.

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APA 4ort.xyz Knowledge Graph. (2026). Senataxin. Retrieved October 30, 2026, from https://4ort.xyz/entity/senataxin
MLA “Senataxin.” 4ort.xyz Knowledge Graph, 4ort.xyz, 30 Oct. 2026, https://4ort.xyz/entity/senataxin.
BibTeX @misc{4ortxyz_senataxin_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Senataxin}}, year = {2026}, url = {https://4ort.xyz/entity/senataxin}, note = {Accessed: 2026-10-30}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 13w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from → —
    Encoded by → SETX
    Wikidata description → mammalian protein found in Homo sapiens
    Molecular function → transcription termination site sequence-specific DNA binding, nucleotide binding, protein binding +8
    + 9 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 5.6.2.3, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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