Rous sarcoma oncogene
mammalian protein found in Mus musculus
Facts
9 properties- Instance of
- protein
- Part of
- SH3-like domain superfamily, Protein kinase-like domain superfamily, SH2 domain superfamily, membrane protein, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, SH2 domain, protein family, SH3 domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Tyrosine-protein kinase, active site, protein family[2][3][4][5][6][7][8][9][10][11][12]
- Biological process
- response to mineralocorticoid, negative regulation of telomere maintenance via telomerase, response to interleukin-1, positive regulation of canonical Wnt signaling pathway, negative regulation of telomerase activity, regulation of intracellular estrogen receptor signaling pathway, stress fiber assembly, positive regulation of protein serine/threonine kinase activity, cell cycle, substrate adhesion-dependent cell spreading, osteoclast development, transforming growth factor beta receptor signaling pathway, cellular response to hypoxia, cellular response to transforming growth factor beta stimulus, negative regulation of protein homooligomerization, positive regulation of protein kinase B signaling, positive regulation of lamellipodium morphogenesis, branching involved in mammary gland duct morphogenesis, response to mechanical stimulus, response to virus, positive regulation of epithelial cell migration, bone resorption, positive regulation of platelet-derived growth factor receptor signaling pathway, oogenesis, regulation of epithelial cell migration, response to nutrient levels, positive regulation of protein processing, cellular response to insulin stimulus, positive regulation of peptidyl-tyrosine phosphorylation, protein autophosphorylation, innate immune response, response to acidic pH, response to fatty acid, regulation of cell projection assembly, immune system process, negative regulation of mitochondrial depolarization, negative regulation of apoptotic process, cellular response to platelet-derived growth factor stimulus, cellular response to fluid shear stress, response to electrical stimulus, uterus development, cell adhesion, protein destabilization, regulation of cell-cell adhesion, peptidyl-tyrosine autophosphorylation, integrin-mediated signaling pathway, negative regulation of anoikis, response to hydrogen peroxide, positive regulation of protein localization to nucleus, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, regulation of early endosome to late endosome transport, regulation of caveolin-mediated endocytosis, regulation of cell cycle, cellular response to reactive oxygen species, cellular response to peptide hormone stimulus, cellular response to fatty acid, regulation of cell population proliferation, angiotensin-activated signaling pathway involved in heart process, forebrain development, regulation of protein binding, cellular response to lipopolysaccharide, cell migration, negative regulation of intrinsic apoptotic signaling pathway, peptidyl-tyrosine phosphorylation, phosphorylation, protein phosphorylation, intracellular signal transduction, epidermal growth factor receptor signaling pathway, negative regulation of extrinsic apoptotic signaling pathway, positive regulation of podosome assembly, platelet-derived growth factor receptor signaling pathway, positive regulation of small GTPase mediated signal transduction, cell-cell adhesion, primary ovarian follicle growth, cell population proliferation, positive regulation of gene expression, positive regulation of glucose metabolic process, positive regulation of smooth muscle cell migration, peptidyl-serine phosphorylation, positive regulation of protein autophosphorylation, activation of protein kinase B activity, adherens junction organization, positive regulation of apoptotic process, positive regulation of MAP kinase activity, positive regulation of phosphatidylinositol 3-kinase activity, transcytosis, positive regulation of cyclin-dependent protein serine/threonine kinase activity, positive regulation of cell adhesion, negative regulation of transcription, DNA-templated, positive regulation of transcription, DNA-templated, positive regulation of insulin receptor signaling pathway, neurotrophin TRK receptor signaling pathway, progesterone receptor signaling pathway, positive regulation of protein transport, negative regulation of focal adhesion assembly, positive regulation of ERK1 and ERK2 cascade, cellular response to progesterone stimulus, positive regulation of intracellular signal transduction, positive regulation of ovarian follicle development, positive regulation of DNA biosynthetic process, regulation of postsynaptic neurotransmitter receptor activity, transmembrane receptor protein tyrosine kinase signaling pathway, cell differentiation, osteoclast development, bone resorption, regulation of postsynaptic neurotransmitter receptor activity, cellular response to hydrogen peroxide, positive regulation of platelet-derived growth factor receptor-beta signaling pathway, odontogenesis
- Cell component
- extrinsic component of cytoplasmic side of plasma membrane, ruffle membrane, mitochondrion, cytoskeleton, lysosome, late endosome, actin filament, mitochondrial inner membrane, nucleus, caveola, cytosol, podosome, cytoplasm, plasma membrane, perinuclear region of cytoplasm, nucleoplasm, postsynaptic density, membrane, neuron projection, glutamatergic synapse, postsynaptic specialization, intracellular component, glutamatergic synapse, postsynaptic specialization, intracellular component
- Encoded by
- Src
- Found in taxon
- house mouse
- Has part(s)
- SH2 domain, tyrosine-protein kinase, catalytic domain, tyrosine-protein kinase, active site, serine-threonine/tyrosine-protein kinase, catalytic domain, SH3 domain, protein kinase, ATP binding site, protein kinase domain[13][14][15][16][17][18][19]
- Imported from
- wholeness_audit_2026-05-02
- Molecular function
- transmembrane transporter binding, protein domain specific binding, SH2 domain binding, signaling receptor binding, ATP binding, kinase binding, heme binding, enzyme binding, transferase activity, scaffold protein binding, protein binding, hormone receptor binding, nucleotide binding, phosphoprotein binding, growth factor receptor binding, protein kinase activity, non-membrane spanning protein tyrosine kinase activity, kinase activity, ephrin receptor binding, protein C-terminus binding, connexin binding, protein tyrosine kinase activity, protein kinase C binding, insulin receptor binding, protein kinase binding, estrogen receptor binding, ubiquitin protein ligase binding, protein-containing complex binding, cadherin binding, cell adhesion molecule binding, signaling receptor binding, integrin binding, integrin binding
🏷️ Also known as
en neuronal proto-oncogene tyrosine-protein kinase Src
en p60-Src
en pp60c-src
en proto-oncogene c-Src
en proto-oncogene tyrosine-protein kinase Src
en Rous sarcoma oncogene
en Src
🔖 Identifiers · 3
- Ensembl protein ID
- ENSMUSP00000090237, ENSMUSP00000105155, ENSMUSP00000029175, ENSMUSP00000105157, ENSMUSP00000105159
- RefSeq protein ID
- NP_001020566, NP_033297, XP_006499126, XP_006499128, XP_006499129, XP_011237704, XP_011237705, XP_011237706, XP_030104859, XP_030104861, XP_030104862, XP_036015972, XP_036015973, XP_036015974, XP_036015976, XP_036015977, XP_036015978
- UniProt protein ID
- P05480
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Summary
Rous sarcoma oncogene is a protein[1].