Ring finger protein 8
mammalian protein found in Homo sapiens
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Summary
Ring finger protein 8 is a protein[1]. It is known by 8 alternative names across languages and contexts.[2]
Key Facts
- Part of: Zinc finger, RING/FYVE/PHD-type[3], E3 ubiquitin-protein ligase RNF8[4], SMAD/FHA domain superfamily[5], Zinc finger, RING-type, protein family[6], Forkhead-associated (FHA) domain, protein family[7], Zinc finger, RING-type, conserved site, protein family[8]
- Has part(s): Zinc finger, RING-type, conserved site[9], forkhead-associated (FHA) domain[10], Zinc finger, RING-type[11]
- Molecular function: protein homodimerization activity[12], histone binding[13], chromatin binding[14], metal ion binding[15], ubiquitin-protein transferase activity[16], protein binding[17], ubiquitin protein ligase binding[18], transferase activity[19], identical protein binding[20], zinc ion binding[21], ubiquitin binding[22], ubiquitin protein ligase activity[23]
- Cell component: site of double-strand break[24], ubiquitin ligase complex[25], nucleoplasm[26], chromosome[27], telomere[28], midbody[29], nucleus[30], cytosol[31], cytoplasm[32]
- Biological process: response to ionizing radiation[33], histone H2A ubiquitination[34], interstrand cross-link repair[35], ubiquitin-dependent protein catabolic process[36], protein K63-linked ubiquitination[37], positive regulation of DNA repair[38], histone H2A K63-linked ubiquitination[39], negative regulation of transcription elongation from RNA polymerase II promoter[40], cellular response to DNA damage stimulus[41], cell division[42], protein K48-linked ubiquitination[43], isotype switching[44], protein ubiquitination[45], spermatid development[46]