Ribosomal protein S6 kinase B1

mammalian protein found in Homo sapiens

Protein protein Q21114975

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Ribosomal protein S6 kinase B1

Summary

Ribosomal protein S6 kinase B1 is a protein^[1].

Key Facts

Ribosomal protein S6 kinase B1's instance of is recorded as protein^[2].
Ribosomal protein S6 kinase B1's physically interacts with is recorded as ly-2584702^[3].
Ribosomal protein S6 kinase B1 is part of Protein kinase-like domain superfamily^[4].
Ribosomal protein S6 kinase B1 is part of ribosomal protein S6 kinase^[5].
Ribosomal protein S6 kinase B1 is part of Protein kinase, C-terminal domain, protein family^[6].
Ribosomal protein S6 kinase B1 is part of AGC-kinase, C-terminal domain, protein family^[7].
Ribosomal protein S6 kinase B1 is part of Protein kinase domain, protein family^[8].
Ribosomal protein S6 kinase B1 is part of Protein kinase, ATP binding site, protein family^[9].
Ribosomal protein S6 kinase B1 is part of Serine/threonine-protein kinase, active site, protein family^[10].
Ribosomal protein S6 kinase B1 comprises AGC-kinase, C-terminal^[11].
Ribosomal protein S6 kinase B1 comprises protein kinase, ATP binding site^[12].
Ribosomal protein S6 kinase B1 comprises protein kinase domain^[13].
Ribosomal protein S6 kinase B1 comprises protein kinase, C-terminal^[14].
Ribosomal protein S6 kinase B1 comprises serine/threonine-protein kinase, active site^[15].
Ribosomal protein S6 kinase B1's molecular function is recorded as transferase activity^[16].
Ribosomal protein S6 kinase B1's molecular function is recorded as protein kinase activity^[17].
Ribosomal protein S6 kinase B1's molecular function is recorded as nucleotide binding^[18].
Ribosomal protein S6 kinase B1's molecular function is recorded as peptide binding^[19].
Ribosomal protein S6 kinase B1's molecular function is recorded as protein binding^[20].
Ribosomal protein S6 kinase B1's molecular function is recorded as identical protein binding^[21].
Ribosomal protein S6 kinase B1's molecular function is recorded as protein serine/threonine/tyrosine kinase activity^[22].
Ribosomal protein S6 kinase B1's molecular function is recorded as ATP binding^[23].
Ribosomal protein S6 kinase B1's molecular function is recorded as kinase activity^[24].
Ribosomal protein S6 kinase B1's molecular function is recorded as protein serine/threonine kinase activity^[25].
Ribosomal protein S6 kinase B1's molecular function is recorded as ribosomal protein S6 kinase activity^[26].

⭐ Popularity Graph

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Quick Facts

Instance of protein

Part of Protein kinase-like domain superfamily, ribosomal protein S6 kinase, Protein kinase, C-terminal domain, protein family, AGC-kinase, C-terminal domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Serine/threonine-protein kinase, active site, protein family

Properties

Biological process germ cell development, response to amino acid, response to glucagon, response to organic cyclic compound, protein kinase B signaling, response to nutrient, phosphorylation, regulation of glucose import, response to testosterone, negative regulation of extrinsic apoptotic signaling pathway, cellular response to growth factor stimulus, skeletal muscle contraction, response to mechanical stimulus, ageing, response to leucine, cellular response to organic cyclic compound, positive regulation of mitotic cell cycle, negative regulation of apoptotic process, response to heat, response to glucocorticoid, response to glucose, response to peptide hormone, behavioral fear response, positive regulation of translation, response to organic substance, positive regulation of smooth muscle cell migration, response to tumor necrosis factor, response to insulin, response to lipopolysaccharide, negative regulation of insulin receptor signaling pathway, cellular response to hormone stimulus, long-term memory, response to wounding, response to organonitrogen compound, response to electrical stimulus involved in regulation of muscle adaptation, skeletal muscle atrophy, cell cycle, response to ethanol, positive regulation of translational initiation, cell migration, response to toxic substance, positive regulation of skeletal muscle tissue growth, regulation of translation, phosphatidylinositol-mediated signaling, signal transduction, positive regulation of smooth muscle cell proliferation, apoptotic process, protein phosphorylation, cellular response to dexamethasone stimulus, cellular response to insulin stimulus, G1/S transition of mitotic cell cycle, peptidyl-serine phosphorylation, TOR signaling, cellular response to interferon-gamma, long-chain fatty acid import into cell, protein phosphorylation, cellular response to insulin stimulus, intracellular signal transduction, positive regulation of translational initiation, response to nutrient levels, peptidyl-serine phosphorylation, cellular response to insulin stimulus, negative regulation of apoptotic process, long-chain fatty acid import into cell, negative regulation of insulin receptor signaling pathway

Cell component cytoplasm, cytosol, membrane, synapse, nucleoplasm, cell surface, mitochondrial outer membrane, cell junction, mitochondrion, perinuclear region of cytoplasm, neuron projection, nucleus, nucleus, cytoplasm, cytoplasm, cytosol

Ec enzyme number 2.7.11.1

Encoded by RPS6KB1

Found in taxon Homo sapiens

Has part(s) AGC-kinase, C-terminal, protein kinase, ATP binding site, protein kinase domain, protein kinase, C-terminal, serine/threonine-protein kinase, active site

Molecular function transferase activity, protein kinase activity, nucleotide binding, peptide binding, protein binding, identical protein binding, protein serine/threonine/tyrosine kinase activity, ATP binding, kinase activity, protein serine/threonine kinase activity, ribosomal protein S6 kinase activity, PDZ domain binding, protein phosphatase 2A binding, ribosomal protein S6 kinase activity, ribosomal protein S6 kinase activity

Physically interacts with ly-2584702

External References (4)

Ensembl protein id ENSP00000225577, ENSP00000376744, ENSP00000384335, ENSP00000441993, ENSP00000464805, ENSP00000466562, ENSP00000468058

Pdb structure id 3A60, 3A61, 3A62, 3WE4, 3WF5, 3WF6, 3WF7, 3WF8, 3WF9, 4L3J, 4L3L, 4L42, 4L43, 4L44, 4L45, 4L46, 4RLO, 4RLP

Refseq protein id NP_001258971, NP_001258972, NP_001258973, NP_001258989, NP_003152, XP_011523404, NP_001356598, NP_001356599, NP_001356600, NP_001356601, NP_001356602, NP_001356603, NP_001356604, NP_001356605, NP_001356606, NP_001356607, NP_001356608

Uniprot protein id P23443

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Ribosomal protein S6 kinase B1 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Ribosomal protein S6 kinase B1 — physically interacts with (P129): ly-2584702. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[4] ↑ Ribosomal protein S6 kinase B1 — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Ribosomal protein S6 kinase B1 — part of (P361): ribosomal protein S6 kinase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Ribosomal protein S6 kinase B1 — part of (P361): Protein kinase, C-terminal domain, protein family. wikidata.org.
[7] ↑ Ribosomal protein S6 kinase B1 — part of (P361): AGC-kinase, C-terminal domain, protein family. wikidata.org.
[8] ↑ Ribosomal protein S6 kinase B1 — part of (P361): Protein kinase domain, protein family. wikidata.org.
[9] ↑ Ribosomal protein S6 kinase B1 — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[10] ↑ Ribosomal protein S6 kinase B1 — part of (P361): Serine/threonine-protein kinase, active site, protein family. wikidata.org.
[11] ↑ Ribosomal protein S6 kinase B1 — has part(s) (P527): AGC-kinase, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Ribosomal protein S6 kinase B1 — has part(s) (P527): protein kinase, ATP binding site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Ribosomal protein S6 kinase B1 — has part(s) (P527): protein kinase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Ribosomal protein S6 kinase B1 — has part(s) (P527): protein kinase, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Ribosomal protein S6 kinase B1 — has part(s) (P527): serine/threonine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Ribosomal protein S6 kinase B1 — molecular function (P680): transferase activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Ribosomal protein S6 kinase B1 — molecular function (P680): protein kinase activity. Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Ribosomal protein S6 kinase B1 — molecular function (P680): nucleotide binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Ribosomal protein S6 kinase B1 — molecular function (P680): peptide binding. GOA. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Ribosomal protein S6 kinase B1 — molecular function (P680): protein binding. S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Ribosomal protein S6 kinase B1 — molecular function (P680): identical protein binding. GOA. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Ribosomal protein S6 kinase B1 — molecular function (P680): protein serine/threonine/tyrosine kinase activity. ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Ribosomal protein S6 kinase B1 — molecular function (P680): ATP binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Ribosomal protein S6 kinase B1 — molecular function (P680): kinase activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Ribosomal protein S6 kinase B1 — molecular function (P680): protein serine/threonine kinase activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Ribosomal protein S6 kinase B1 — molecular function (P680): ribosomal protein S6 kinase activity. GOA. Retrieved 2018-07-16. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Ribosomal protein S6 kinase B1 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). Ribosomal protein S6 kinase B1. Retrieved May 3, 2026, from https://4ort.xyz/entity/ribosomal-protein-s6-kinase-b1

MLA

“Ribosomal protein S6 kinase B1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/ribosomal-protein-s6-kinase-b1.

BibTeX

@misc{4ortxyz_ribosomal-protein-s6-kinase-b1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Ribosomal protein S6 kinase B1}}, year = {2026}, url = {https://4ort.xyz/entity/ribosomal-protein-s6-kinase-b1}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Ribosomal protein S6 kinase B1 — https://4ort.xyz/entity/ribosomal-protein-s6-kinase-b1 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/ribosomal-protein-s6-kinase-b1 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

4w ago · Boghog · 2026-07-24 view diff on Wikidata ↗

Imported from → —

Encoded by → RPS6KB1

Wikidata description → mammalian protein found in Homo sapiens

Molecular function → transferase activity, protein kinase activity, nucleotide binding +12

+ 12 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.7.11.1, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"

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