Ribosomal protein S6 kinase A4

mammalian protein found in Homo sapiens

Protein protein Q21119246

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Ribosomal protein S6 kinase A4

Summary

Ribosomal protein S6 kinase A4 is a protein^[1].

Key Facts

Ribosomal protein S6 kinase A4's instance of is recorded as protein^[2].
Ribosomal protein S6 kinase A4 is part of ribosomal protein S6 kinase II^[3].
Ribosomal protein S6 kinase A4 is part of Protein kinase-like domain superfamily^[4].
Ribosomal protein S6 kinase A4 is part of Protein kinase, C-terminal domain, protein family^[5].
Ribosomal protein S6 kinase A4 is part of AGC-kinase, C-terminal domain, protein family^[6].
Ribosomal protein S6 kinase A4 is part of Protein kinase domain, protein family^[7].
Ribosomal protein S6 kinase A4 is part of Protein kinase, ATP binding site, protein family^[8].
Ribosomal protein S6 kinase A4 is part of MSK2, N-terminal catalytic domain, protein family^[9].
Ribosomal protein S6 kinase A4 is part of Serine/threonine-protein kinase, active site, protein family^[10].
Ribosomal protein S6 kinase A4 comprises AGC-kinase, C-terminal^[11].
Ribosomal protein S6 kinase A4 comprises protein kinase, ATP binding site^[12].
Ribosomal protein S6 kinase A4 comprises protein kinase domain^[13].
Ribosomal protein S6 kinase A4 comprises protein kinase, C-terminal^[14].
Ribosomal protein S6 kinase A4 comprises serine/threonine-protein kinase, active site^[15].
Ribosomal protein S6 kinase A4 comprises MSK2, N-terminal catalytic domain^[16].
Ribosomal protein S6 kinase A4's molecular function is recorded as transferase activity^[17].
Ribosomal protein S6 kinase A4's molecular function is recorded as nucleotide binding^[18].
Ribosomal protein S6 kinase A4's molecular function is recorded as protein kinase activity^[19].
Ribosomal protein S6 kinase A4's molecular function is recorded as metal ion binding^[20].
Ribosomal protein S6 kinase A4's molecular function is recorded as kinase activity^[21].
Ribosomal protein S6 kinase A4's molecular function is recorded as protein serine/threonine kinase activity^[22].
Ribosomal protein S6 kinase A4's molecular function is recorded as ribosomal protein S6 kinase activity^[23].
Ribosomal protein S6 kinase A4's molecular function is recorded as protein binding^[24].
Ribosomal protein S6 kinase A4's molecular function is recorded as ATP binding^[25].
Ribosomal protein S6 kinase A4's molecular function is recorded as magnesium ion binding^[26].

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Quick Facts

Instance of protein

Part of ribosomal protein S6 kinase II, Protein kinase-like domain superfamily, Protein kinase, C-terminal domain, protein family, AGC-kinase, C-terminal domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, MSK2, N-terminal catalytic domain, protein family, Serine/threonine-protein kinase, active site, protein family

Properties

Biological process intracellular signal transduction, regulation of transcription, DNA-templated, phosphorylation, positive regulation of histone acetylation, interleukin-1-mediated signaling pathway, protein phosphorylation, positive regulation of CREB transcription factor activity, positive regulation of NF-kappaB transcription factor activity, inflammatory response, negative regulation of cytokine production, positive regulation of transcription by RNA polymerase II, protein phosphorylation, intracellular signal transduction

Cell component nucleoplasm, nucleus, cytoplasm, cytosol, nucleus

Ec enzyme number 2.7.11.1

Encoded by RPS6KA4

Found in taxon Homo sapiens

Has part(s) AGC-kinase, C-terminal, protein kinase, ATP binding site, protein kinase domain, protein kinase, C-terminal, serine/threonine-protein kinase, active site, MSK2, N-terminal catalytic domain

Molecular function transferase activity, nucleotide binding, protein kinase activity, metal ion binding, kinase activity, protein serine/threonine kinase activity, ribosomal protein S6 kinase activity, protein binding, ATP binding, magnesium ion binding, protein serine/threonine kinase activity

External References (3)

Ensembl protein id ENSP00000333896, ENSP00000432945, ENSP00000435314, ENSP00000435580

Refseq protein id NP_001006945, NP_001287731, NP_001305290, NP_003933, XP_005274437, XP_016874016

Uniprot protein id O75676

🏷️ Also known as

en 90 kDa ribosomal protein S6 kinase 4 en mitogen- and stress-activated protein kinase 2 en nuclear mitogen- and stress-activated protein kinase 2 en ribosomal protein kinase B en ribosomal protein S6 kinase, 90kDa, polypeptide 4 en Ribosomal protein S6 kinase A4 en ribosomal protein S6 kinase alpha-4 en RPS6KA4 en RSKB

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Ribosomal protein S6 kinase A4 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Ribosomal protein S6 kinase A4 — part of (P361): ribosomal protein S6 kinase II. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[4] ↑ Ribosomal protein S6 kinase A4 — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Ribosomal protein S6 kinase A4 — part of (P361): Protein kinase, C-terminal domain, protein family. wikidata.org.
[6] ↑ Ribosomal protein S6 kinase A4 — part of (P361): AGC-kinase, C-terminal domain, protein family. wikidata.org.
[7] ↑ Ribosomal protein S6 kinase A4 — part of (P361): Protein kinase domain, protein family. wikidata.org.
[8] ↑ Ribosomal protein S6 kinase A4 — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[9] ↑ Ribosomal protein S6 kinase A4 — part of (P361): MSK2, N-terminal catalytic domain, protein family. wikidata.org.
[10] ↑ Ribosomal protein S6 kinase A4 — part of (P361): Serine/threonine-protein kinase, active site, protein family. wikidata.org.
[11] ↑ Ribosomal protein S6 kinase A4 — has part(s) (P527): AGC-kinase, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Ribosomal protein S6 kinase A4 — has part(s) (P527): protein kinase, ATP binding site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Ribosomal protein S6 kinase A4 — has part(s) (P527): protein kinase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Ribosomal protein S6 kinase A4 — has part(s) (P527): protein kinase, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Ribosomal protein S6 kinase A4 — has part(s) (P527): serine/threonine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Ribosomal protein S6 kinase A4 — has part(s) (P527): MSK2, N-terminal catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Ribosomal protein S6 kinase A4 — molecular function (P680): transferase activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Ribosomal protein S6 kinase A4 — molecular function (P680): nucleotide binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Ribosomal protein S6 kinase A4 — molecular function (P680): protein kinase activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Ribosomal protein S6 kinase A4 — molecular function (P680): metal ion binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Ribosomal protein S6 kinase A4 — molecular function (P680): kinase activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Ribosomal protein S6 kinase A4 — molecular function (P680): protein serine/threonine kinase activity. MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. Retrieved 2018-03-27. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Ribosomal protein S6 kinase A4 — molecular function (P680): ribosomal protein S6 kinase activity. C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB). Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Ribosomal protein S6 kinase A4 — molecular function (P680): protein binding. The protein interaction landscape of the human CMGC kinase group. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Ribosomal protein S6 kinase A4 — molecular function (P680): ATP binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Ribosomal protein S6 kinase A4 — molecular function (P680): magnesium ion binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Ribosomal protein S6 kinase A4 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). Ribosomal protein S6 kinase A4. Retrieved May 3, 2026, from https://4ort.xyz/entity/ribosomal-protein-s6-kinase-a4

MLA

“Ribosomal protein S6 kinase A4.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/ribosomal-protein-s6-kinase-a4.

BibTeX

@misc{4ortxyz_ribosomal-protein-s6-kinase-a4_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Ribosomal protein S6 kinase A4}}, year = {2026}, url = {https://4ort.xyz/entity/ribosomal-protein-s6-kinase-a4}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Ribosomal protein S6 kinase A4 — https://4ort.xyz/entity/ribosomal-protein-s6-kinase-a4 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/ribosomal-protein-s6-kinase-a4 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

5w ago · Boghog · 2026-07-24 view diff on Wikidata ↗

Imported from → —

Encoded by → RPS6KA4

Wikidata description → mammalian protein found in Homo sapiens

Molecular function → transferase activity, nucleotide binding, protein kinase activity +8

+ 10 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.7.11.1, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"

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