Ret proto-oncogene

mammalian protein found in Mus musculus

Protein protein Q21989450

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Ret proto-oncogene

Summary

Ret proto-oncogene is a protein^[1].

Key Facts

Ret proto-oncogene's instance of is recorded as protein^[2].
Ret proto-oncogene's UniProt protein ID is recorded as P35546^[3].
Ret proto-oncogene's part of is recorded as Cadherin-like superfamily^[4].
Ret proto-oncogene's part of is recorded as Protein kinase-like domain superfamily^[5].
Ret proto-oncogene's part of is recorded as tyrosine-protein kinase, Ret receptor^[6].
Ret proto-oncogene's part of is recorded as membrane protein^[7].
Ret proto-oncogene's part of is recorded as Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family^[8].
Ret proto-oncogene's part of is recorded as Protein kinase domain, protein family^[9].
Ret proto-oncogene's part of is recorded as Cadherin-like, protein family^[10].
Ret proto-oncogene's part of is recorded as Protein kinase, ATP binding site, protein family^[11].
Ret proto-oncogene's part of is recorded as Tyrosine-protein kinase, catalytic domain, protein family^[12].
Ret proto-oncogene's part of is recorded as Tyrosine-protein kinase, active site, protein family^[13].
Ret proto-oncogene's has part is recorded as cadherin^[14].
Ret proto-oncogene's has part is recorded as tyrosine-protein kinase, catalytic domain^[15].
Ret proto-oncogene's has part is recorded as tyrosine-protein kinase, active site^[16].
Ret proto-oncogene's has part is recorded as serine-threonine/tyrosine-protein kinase, catalytic domain^[17].
Ret proto-oncogene's has part is recorded as protein kinase, ATP binding site^[18].
Ret proto-oncogene's has part is recorded as protein kinase domain^[19].
Ret proto-oncogene's RefSeq protein ID is recorded as NP_001074249^[20].
Ret proto-oncogene's RefSeq protein ID is recorded as NP_033076^[21].
Ret proto-oncogene's PDB structure ID is recorded as 1UEF^[22].
Ret proto-oncogene's molecular function is recorded as transferase activity^[23].
Ret proto-oncogene's molecular function is recorded as nucleotide binding^[24].
Ret proto-oncogene's molecular function is recorded as protein kinase activity^[25].
Ret proto-oncogene's molecular function is recorded as calcium ion binding^[26].

⭐ Popularity Graph

0/100 established

Quick Facts

Instance of protein

Part of Cadherin-like superfamily, Protein kinase-like domain superfamily, tyrosine-protein kinase, Ret receptor, membrane protein, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, Protein kinase domain, protein family, Cadherin-like, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Tyrosine-protein kinase, active site, protein family

Properties

Biological process cellular response to retinoic acid, ureteric bud development, embryonic epithelial tube formation, phosphorylation, membrane protein proteolysis, transmembrane receptor protein tyrosine kinase signaling pathway, positive regulation of cell migration, neuron cell-cell adhesion, anatomical structure morphogenesis, nervous system development, MAPK cascade, neuron maturation, positive regulation of metanephric glomerulus development, positive regulation of transcription, DNA-templated, regulation of axonogenesis, protein phosphorylation, enteric nervous system development, positive regulation of gene expression, cell adhesion, regulation of cell adhesion, ureter maturation, response to pain, retina development in camera-type eye, neural crest cell migration, neuron differentiation, positive regulation of cell size, positive regulation of neuron projection development, positive regulation of cell adhesion mediated by integrin, homophilic cell adhesion via plasma membrane adhesion molecules, Peyer's patch morphogenesis, peptidyl-tyrosine phosphorylation, activation of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of extrinsic apoptotic signaling pathway in absence of ligand, regulation of peptidyl-serine phosphorylation of STAT protein, positive regulation of peptidyl-serine phosphorylation of STAT protein, positive regulation of neuron maturation, glial cell-derived neurotrophic factor receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of protein kinase B signaling, innervation, glial cell-derived neurotrophic factor receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of protein kinase B signaling, embryonic epithelial tube formation, negative regulation of signal transduction, cell differentiation, positive regulation of peptidyl-serine phosphorylation of STAT protein, negative regulation of apoptotic process, positive regulation of ERK1 and ERK2 cascade, transmembrane receptor protein tyrosine kinase signaling pathway, nervous system development, neurogenesis, positive regulation of MAPK cascade, positive regulation of protein kinase B signaling

Cell component integral component of membrane, endosome, membrane, intracellular membrane-bounded organelle, receptor complex, integral component of plasma membrane, endosome membrane, cytosol, plasma membrane protein complex, early endosome, plasma membrane, axon, dendrite, soma, membrane raft, cytoplasm, integral component of plasma membrane, axon, receptor complex

Encoded by Ret

Found in taxon house mouse

Has part(s) cadherin, tyrosine-protein kinase, catalytic domain, tyrosine-protein kinase, active site, serine-threonine/tyrosine-protein kinase, catalytic domain, protein kinase, ATP binding site, protein kinase domain

Imported from wholeness_audit_2026-05-02

Molecular function transferase activity, nucleotide binding, protein kinase activity, calcium ion binding, kinase activity, protein binding, protein tyrosine kinase activity, ATP binding, transmembrane receptor protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity, receptor tyrosine kinase, transmembrane signaling receptor activity, transmembrane receptor protein tyrosine kinase activity

External References (3)

Pdb structure id 1UEF

Refseq protein id NP_001074249, NP_033076

Uniprot protein id P35546

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Ret proto-oncogene — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Ret proto-oncogene — UniProt protein ID (P352): P35546. Q905695. Retrieved 2022-05-25. wikidata.org.
[4] ↑ Ret proto-oncogene — part of (P361): Cadherin-like superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Ret proto-oncogene — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Ret proto-oncogene — part of (P361): tyrosine-protein kinase, Ret receptor. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Ret proto-oncogene — part of (P361): membrane protein. wikidata.org.
[8] ↑ Ret proto-oncogene — part of (P361): Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[9] ↑ Ret proto-oncogene — part of (P361): Protein kinase domain, protein family. wikidata.org.
[10] ↑ Ret proto-oncogene — part of (P361): Cadherin-like, protein family. wikidata.org.
[11] ↑ Ret proto-oncogene — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[12] ↑ Ret proto-oncogene — part of (P361): Tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[13] ↑ Ret proto-oncogene — part of (P361): Tyrosine-protein kinase, active site, protein family. wikidata.org.
[14] ↑ Ret proto-oncogene — has part(s) (P527): cadherin. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Ret proto-oncogene — has part(s) (P527): tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Ret proto-oncogene — has part(s) (P527): tyrosine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Ret proto-oncogene — has part(s) (P527): serine-threonine/tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Ret proto-oncogene — has part(s) (P527): protein kinase, ATP binding site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Ret proto-oncogene — has part(s) (P527): protein kinase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Ret proto-oncogene — RefSeq protein ID (P637): NP_001074249. Q20641742. Retrieved 2022-03-20. wikidata.org.
[21] ↑ Ret proto-oncogene — RefSeq protein ID (P637): NP_033076. Q20641742. Retrieved 2022-03-20. wikidata.org.
[22] ↑ Ret proto-oncogene — PDB structure ID (P638): 1UEF. Q905695. Retrieved 2016-08-09. wikidata.org.
[23] ↑ Ret proto-oncogene — molecular function (P680): transferase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Ret proto-oncogene — molecular function (P680): nucleotide binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Ret proto-oncogene — molecular function (P680): protein kinase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Ret proto-oncogene — molecular function (P680): calcium ion binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Ret proto-oncogene is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Ret proto-oncogene. Retrieved May 3, 2026, from https://4ort.xyz/entity/ret-proto-oncogene-q21989450

MLA

“Ret proto-oncogene.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/ret-proto-oncogene-q21989450.

BibTeX

@misc{4ortxyz_ret-proto-oncogene-q21989450_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Ret proto-oncogene}}, year = {2026}, url = {https://4ort.xyz/entity/ret-proto-oncogene-q21989450}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Ret proto-oncogene — https://4ort.xyz/entity/ret-proto-oncogene-q21989450 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/ret-proto-oncogene-q21989450 · Last refreshed: May 3, 2026