RELA proto-oncogene, NF-kB subunit

mammalian protein found in Homo sapiens

Protein protein Q4047839

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Summary

RELA proto-oncogene, NF-kB subunit is a protein^[1].

Key Facts

RELA proto-oncogene, NF-kB subunit's instance of is recorded as protein^[2].
RELA proto-oncogene, NF-kB subunit's UniProt protein ID is recorded as Q04206^[3].
RELA proto-oncogene, NF-kB subunit's part of is recorded as p53-like transcription factor, DNA-binding^[4].
RELA proto-oncogene, NF-kB subunit's part of is recorded as Immunoglobulin-like fold^[5].
RELA proto-oncogene, NF-kB subunit's part of is recorded as transcription factor RelA (p65)^[6].
RELA proto-oncogene, NF-kB subunit's part of is recorded as Immunoglobulin E-set^[7].
RELA proto-oncogene, NF-kB subunit's part of is recorded as Rel homology domain (RHD), DNA-binding domain superfamily^[8].
RELA proto-oncogene, NF-kB subunit's part of is recorded as IPT domain, protein family^[9].
RELA proto-oncogene, NF-kB subunit's part of is recorded as Rel homology dimerisation domain, protein family^[10].
RELA proto-oncogene, NF-kB subunit's part of is recorded as Rel homology domain (RHD), DNA-binding domain, protein family^[11].
RELA proto-oncogene, NF-kB subunit's part of is recorded as NFkappaB IPT domain, protein family^[12].
RELA proto-oncogene, NF-kB subunit's part of is recorded as Rel homology domain, conserved site, protein family^[13].
RELA proto-oncogene, NF-kB subunit's has part is recorded as IPT domain^[14].
RELA proto-oncogene, NF-kB subunit's has part is recorded as Rel homology dimerisation domain^[15].
RELA proto-oncogene, NF-kB subunit's has part is recorded as Rel homology domain, conserved site^[16].
RELA proto-oncogene, NF-kB subunit's has part is recorded as Rel homology domain (RHD), DNA-binding domain^[17].
RELA proto-oncogene, NF-kB subunit's has part is recorded as NFkappaB IPT domain^[18].
RELA proto-oncogene, NF-kB subunit's RefSeq protein ID is recorded as NP_001138610^[19].
RELA proto-oncogene, NF-kB subunit's RefSeq protein ID is recorded as NP_001230913^[20].
RELA proto-oncogene, NF-kB subunit's RefSeq protein ID is recorded as NP_001230914^[21].
RELA proto-oncogene, NF-kB subunit's RefSeq protein ID is recorded as NP_068810^[22].
RELA proto-oncogene, NF-kB subunit's RefSeq protein ID is recorded as XP_011543508^[23].
RELA proto-oncogene, NF-kB subunit's RefSeq protein ID is recorded as XP_011543509^[24].
RELA proto-oncogene, NF-kB subunit's PDB structure ID is recorded as 4KV4^[25].
RELA proto-oncogene, NF-kB subunit's PDB structure ID is recorded as 1NFI^[26].

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Quick Facts

Instance of protein

Part of p53-like transcription factor, DNA-binding, Immunoglobulin-like fold, transcription factor RelA (p65), Immunoglobulin E-set, Rel homology domain (RHD), DNA-binding domain superfamily, IPT domain, protein family, Rel homology dimerisation domain, protein family, Rel homology domain (RHD), DNA-binding domain, protein family, NFkappaB IPT domain, protein family, Rel homology domain, conserved site, protein family

Properties

Biological process response to amino acid, response to interleukin-1, cellular response to interleukin-6, response to progesterone, response to organic substance, Fc-epsilon receptor signaling pathway, negative regulation of insulin receptor signaling pathway, defense response to virus, positive regulation of chondrocyte differentiation, animal organ morphogenesis, response to muscle stretch, response to cytokine, negative regulation of protein catabolic process, cytokine-mediated signaling pathway, negative regulation of extrinsic apoptotic signaling pathway, response to mechanical stimulus, response to muramyl dipeptide, stimulatory C-type lectin receptor signaling pathway, transcription, DNA-templated, response to insulin, negative regulation of NIK/NF-kappaB signaling, nucleotide-binding oligomerization domain containing 2 signaling pathway, membrane protein intracellular domain proteolysis, inflammatory response, viral process, response to cobalamin, hair follicle development, positive regulation of miRNA metabolic process, acetaldehyde metabolic process, cellular response to hepatocyte growth factor stimulus, cellular response to nicotine, negative regulation of apoptotic process, cellular defense response, response to morphine, response to lipopolysaccharide, cellular response to interleukin-1, response to inorganic substance, regulation of inflammatory response, response to cAMP, negative regulation of transcription, DNA-templated, response to hydrogen peroxide, positive regulation of Schwann cell differentiation, defense response, response to bacterium, response to organic cyclic compound, ageing, positive regulation of cell population proliferation, positive regulation of I-kappaB kinase/NF-kappaB signaling, liver development, response to UV-B, T cell receptor signaling pathway, cellular response to lipopolysaccharide, positive regulation of type I interferon production, positive regulation of transcription by RNA polymerase II, cellular response to hydrogen peroxide, regulation of transcription, DNA-templated, tumor necrosis factor-mediated signaling pathway, positive regulation of transcription, DNA-templated, positive regulation of T cell receptor signaling pathway, positive regulation of NF-kappaB transcription factor activity, cellular response to peptidoglycan, cellular response to tumor necrosis factor, regulation of NIK/NF-kappaB signaling, positive regulation of NIK/NF-kappaB signaling, positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus, positive regulation of pri-miRNA transcription by RNA polymerase II, regulation of DNA-templated transcription in response to stress, cellular response to lipoteichoic acid, negative regulation of transcription by RNA polymerase II, negative regulation of protein sumoylation, pri-miRNA transcription by RNA polymerase II, cellular response to angiotensin, interleukin-1-mediated signaling pathway, cellular response to vascular endothelial growth factor stimulus, negative regulation of pri-miRNA transcription by RNA polymerase II, postsynapse to nucleus signaling pathway, negative regulation of transcription by RNA polymerase II, chromatin organization, inflammatory response, I-kappaB kinase/NF-kappaB signaling, response to cytokine, NIK/NF-kappaB signaling, positive regulation of transcription by RNA polymerase II, positive regulation of leukocyte adhesion to vascular endothelial cell, positive regulation of transcription by RNA polymerase II, cellular response to lipopolysaccharide

Cell component cytoplasm, cytosol, I-kappaB/NF-kappaB complex, transcription regulator complex, NF-kappaB complex, nucleoplasm, nucleus, nucleolus, NF-kappaB p50/p65 complex, protein-containing complex, synapse, glutamatergic synapse, nucleoplasm, cytosol

Encoded by RELA

Found in taxon Homo sapiens

Has part(s) IPT domain, Rel homology dimerisation domain, Rel homology domain, conserved site, Rel homology domain (RHD), DNA-binding domain, NFkappaB IPT domain

Imported from wholeness_audit_2026-05-02

Molecular function protein N-terminus binding, ankyrin repeat binding, DNA-binding transcription activator activity, RNA polymerase II-specific, histone deacetylase binding, enzyme binding, phosphate ion binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein homodimerization activity, chromatin binding, NF-kappaB binding, protein binding, protein kinase binding, DNA binding, sequence-specific DNA binding, actinin binding, protein heterodimerization activity, transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding, chromatin DNA binding, ubiquitin protein ligase binding, RNA polymerase II general transcription initiation factor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, identical protein binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, transcription factor binding, protein-containing complex binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription activator activity, RNA polymerase II-specific, enzyme binding

External References (4)

Ensembl protein id ENSP00000384273, ENSP00000311508, ENSP00000431153, ENSP00000431304, ENSP00000432537, ENSP00000432922, ENSP00000433144, ENSP00000433526, ENSP00000433616, ENSP00000434008, ENSP00000434098, ENSP00000434372, ENSP00000434745, ENSP00000435290, ENSP00000435531, ENSP00000436545, ENSP00000437137, ENSP00000479572, ENSP00000483705

Pdb structure id 4KV4, 1NFI, 2LSP, 2O61, 3GUT, 3QXY, 3RC0, 4KV1, 2N22

Refseq protein id NP_001138610, NP_001230913, NP_001230914, NP_068810, XP_011543508, XP_011543509

Uniprot protein id Q04206

🏷️ Also known as

en NF-kappa-B p65delta3 en NF-kappa-B transcription factor p65 en nuclear factor NF-kappa-B p65 subunit en nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 en RELA en RELA proto-oncogene, NF-kB subunit en transcription factor p65 en v-rel avian reticuloendotheliosis viral oncogene homolog A en v-rel reticuloendotheliosis viral oncogene homolog A es P65

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ RELA proto-oncogene, NF-kB subunit — instance of (P31): protein. UniProt. Retrieved 2019-11-13. wikidata.org.
[3] ↑ RELA proto-oncogene, NF-kB subunit — UniProt protein ID (P352): Q04206. UniProt. Retrieved 2019-11-13. wikidata.org.
[4] ↑ RELA proto-oncogene, NF-kB subunit — part of (P361): p53-like transcription factor, DNA-binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ RELA proto-oncogene, NF-kB subunit — part of (P361): Immunoglobulin-like fold. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ RELA proto-oncogene, NF-kB subunit — part of (P361): transcription factor RelA (p65). InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ RELA proto-oncogene, NF-kB subunit — part of (P361): Immunoglobulin E-set. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ RELA proto-oncogene, NF-kB subunit — part of (P361): Rel homology domain (RHD), DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ RELA proto-oncogene, NF-kB subunit — part of (P361): IPT domain, protein family. wikidata.org.
[10] ↑ RELA proto-oncogene, NF-kB subunit — part of (P361): Rel homology dimerisation domain, protein family. wikidata.org.
[11] ↑ RELA proto-oncogene, NF-kB subunit — part of (P361): Rel homology domain (RHD), DNA-binding domain, protein family. wikidata.org.
[12] ↑ RELA proto-oncogene, NF-kB subunit — part of (P361): NFkappaB IPT domain, protein family. wikidata.org.
[13] ↑ RELA proto-oncogene, NF-kB subunit — part of (P361): Rel homology domain, conserved site, protein family. wikidata.org.
[14] ↑ RELA proto-oncogene, NF-kB subunit — has part(s) (P527): IPT domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ RELA proto-oncogene, NF-kB subunit — has part(s) (P527): Rel homology dimerisation domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ RELA proto-oncogene, NF-kB subunit — has part(s) (P527): Rel homology domain, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ RELA proto-oncogene, NF-kB subunit — has part(s) (P527): Rel homology domain (RHD), DNA-binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ RELA proto-oncogene, NF-kB subunit — has part(s) (P527): NFkappaB IPT domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ RELA proto-oncogene, NF-kB subunit — RefSeq protein ID (P637): NP_001138610. Q20641742. Retrieved 2020-05-30. wikidata.org.
[20] ↑ RELA proto-oncogene, NF-kB subunit — RefSeq protein ID (P637): NP_001230913. Q20641742. Retrieved 2020-05-30. wikidata.org.
[21] ↑ RELA proto-oncogene, NF-kB subunit — RefSeq protein ID (P637): NP_001230914. Q20641742. Retrieved 2020-05-30. wikidata.org.
[22] ↑ RELA proto-oncogene, NF-kB subunit — RefSeq protein ID (P637): NP_068810. Q20641742. Retrieved 2020-05-30. wikidata.org.
[23] ↑ RELA proto-oncogene, NF-kB subunit — RefSeq protein ID (P637): XP_011543508. Q20641742. Retrieved 2020-05-30. wikidata.org.
[24] ↑ RELA proto-oncogene, NF-kB subunit — RefSeq protein ID (P637): XP_011543509. Q20641742. Retrieved 2020-05-30. wikidata.org.
[25] ↑ RELA proto-oncogene, NF-kB subunit — PDB structure ID (P638): 4KV4. UniProt. Retrieved 2016-08-09. wikidata.org.
[26] ↑ RELA proto-oncogene, NF-kB subunit — PDB structure ID (P638): 1NFI. UniProt. Retrieved 2016-08-09. wikidata.org.

Class ancestry

[1] ↑ RELA proto-oncogene, NF-kB subunit is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). RELA proto-oncogene, NF-kB subunit. Retrieved May 3, 2026, from https://4ort.xyz/entity/rela-proto-oncogene-nf-kb-subunit-q4047839

MLA

“RELA proto-oncogene, NF-kB subunit.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/rela-proto-oncogene-nf-kb-subunit-q4047839.

BibTeX

@misc{4ortxyz_rela-proto-oncogene-nf-kb-subunit-q4047839_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{RELA proto-oncogene, NF-kB subunit}}, year = {2026}, url = {https://4ort.xyz/entity/rela-proto-oncogene-nf-kb-subunit-q4047839}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): RELA proto-oncogene, NF-kB subunit — https://4ort.xyz/entity/rela-proto-oncogene-nf-kb-subunit-q4047839 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/rela-proto-oncogene-nf-kb-subunit-q4047839 · Last refreshed: May 3, 2026