Regulatory factor X, 4 (influences HLA class II expression)

mammalian protein found in Mus musculus

Protein protein Q21496810

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Summary

Regulatory factor X, 4 (influences HLA class II expression) is a protein^[1].

Key Facts

Regulatory factor X, 4 (influences HLA class II expression)'s instance of is recorded as protein^[2].
Regulatory factor X, 4 (influences HLA class II expression)'s subclass of is recorded as protein^[3].
Regulatory factor X, 4 (influences HLA class II expression)'s UniProt protein ID is recorded as Q7TNK1^[4].
Regulatory factor X, 4 (influences HLA class II expression)'s RefSeq protein ID is recorded as NP_001020089^[5].
Regulatory factor X, 4 (influences HLA class II expression)'s RefSeq protein ID is recorded as NP_081965^[6].
Regulatory factor X, 4 (influences HLA class II expression)'s RefSeq protein ID is recorded as XP_006514176^[7].
Regulatory factor X, 4 (influences HLA class II expression)'s RefSeq protein ID is recorded as XP_006514177^[8].
Regulatory factor X, 4 (influences HLA class II expression)'s RefSeq protein ID is recorded as XP_006514178^[9].
Regulatory factor X, 4 (influences HLA class II expression)'s RefSeq protein ID is recorded as XP_030101138^[10].
Regulatory factor X, 4 (influences HLA class II expression)'s RefSeq protein ID is recorded as XP_030101139^[11].
Regulatory factor X, 4 (influences HLA class II expression)'s molecular function is recorded as DNA-binding transcription factor activity^[12].
Regulatory factor X, 4 (influences HLA class II expression)'s molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[13].
Regulatory factor X, 4 (influences HLA class II expression)'s molecular function is recorded as DNA binding^[14].
Regulatory factor X, 4 (influences HLA class II expression)'s molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[15].
Regulatory factor X, 4 (influences HLA class II expression)'s molecular function is recorded as chromatin binding^[16].
Regulatory factor X, 4 (influences HLA class II expression)'s molecular function is recorded as protein binding^[17].
Regulatory factor X, 4 (influences HLA class II expression)'s molecular function is recorded as DNA-binding transcription factor activity^[18].
Regulatory factor X, 4 (influences HLA class II expression)'s cell component is recorded as nucleus^[19].
Regulatory factor X, 4 (influences HLA class II expression)'s cell component is recorded as nucleus^[20].
Regulatory factor X, 4 (influences HLA class II expression)'s biological process is recorded as regulation of transcription by RNA polymerase II^[21].
Regulatory factor X, 4 (influences HLA class II expression)'s biological process is recorded as forebrain development^[22].
Regulatory factor X, 4 (influences HLA class II expression)'s biological process is recorded as telencephalon development^[23].
Regulatory factor X, 4 (influences HLA class II expression)'s biological process is recorded as dorsal spinal cord development^[24].
Regulatory factor X, 4 (influences HLA class II expression)'s biological process is recorded as regulation of transcription, DNA-templated^[25].
Regulatory factor X, 4 (influences HLA class II expression)'s biological process is recorded as negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning^[26].

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Quick Facts

Instance of protein

Subclass of protein

Properties

Biological process regulation of transcription by RNA polymerase II, forebrain development, telencephalon development, dorsal spinal cord development, regulation of transcription, DNA-templated, negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning, transcription, DNA-templated, cerebellar cortex morphogenesis, midbrain development, positive regulation of transcription by RNA polymerase II, regulation of protein processing, transcription by RNA polymerase II, cilium assembly, regulation of transcription by RNA polymerase II, negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning

Cell component nucleus, nucleus

Encoded by Rfx4

Found in taxon house mouse

Imported from wholeness_audit_2026-05-02

Molecular function DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, chromatin binding, protein binding, DNA-binding transcription factor activity

External References (3)

Ensembl protein id ENSMUSP00000051107, ENSMUSP00000093035, ENSMUSP00000128690

Refseq protein id NP_001020089, NP_081965, XP_006514176, XP_006514177, XP_006514178, XP_030101138, XP_030101139

Uniprot protein id Q7TNK1

🏷️ Also known as

en Regulatory factor X 4 en Regulatory factor X, 4 (influences HLA class II expression) en regulatory factor X 4 protein en Rfx4 en transcription factor RFX4 en winged-helix transcription factor RFX4

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Regulatory factor X, 4 (influences HLA class II expression) — instance of (P31): protein. UniProt. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Regulatory factor X, 4 (influences HLA class II expression) — subclass of (P279): protein. UniProt. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Regulatory factor X, 4 (influences HLA class II expression) — UniProt protein ID (P352): Q7TNK1. UniProt. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Regulatory factor X, 4 (influences HLA class II expression) — RefSeq protein ID (P637): NP_001020089. Q20641742. Retrieved 2022-03-20. wikidata.org.
[6] ↑ Regulatory factor X, 4 (influences HLA class II expression) — RefSeq protein ID (P637): NP_081965. Q20641742. Retrieved 2022-03-20. wikidata.org.
[7] ↑ Regulatory factor X, 4 (influences HLA class II expression) — RefSeq protein ID (P637): XP_006514176. Q20641742. Retrieved 2022-03-20. wikidata.org.
[8] ↑ Regulatory factor X, 4 (influences HLA class II expression) — RefSeq protein ID (P637): XP_006514177. Q20641742. Retrieved 2022-03-20. wikidata.org.
[9] ↑ Regulatory factor X, 4 (influences HLA class II expression) — RefSeq protein ID (P637): XP_006514178. Q20641742. Retrieved 2022-03-20. wikidata.org.
[10] ↑ Regulatory factor X, 4 (influences HLA class II expression) — RefSeq protein ID (P637): XP_030101138. Q20641742. Retrieved 2022-03-20. wikidata.org.
[11] ↑ Regulatory factor X, 4 (influences HLA class II expression) — RefSeq protein ID (P637): XP_030101139. Q20641742. Retrieved 2022-03-20. wikidata.org.
[12] ↑ Regulatory factor X, 4 (influences HLA class II expression) — molecular function (P680): DNA-binding transcription factor activity. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Regulatory factor X, 4 (influences HLA class II expression) — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Regulatory factor X, 4 (influences HLA class II expression) — molecular function (P680): DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Regulatory factor X, 4 (influences HLA class II expression) — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. GOA. Retrieved 2018-10-11. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Regulatory factor X, 4 (influences HLA class II expression) — molecular function (P680): chromatin binding. Identification of potential target genes for RFX4_v3, a transcription factor critical for brain development. Retrieved 2018-03-27. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Regulatory factor X, 4 (influences HLA class II expression) — molecular function (P680): protein binding. G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Regulatory factor X, 4 (influences HLA class II expression) — molecular function (P680): DNA-binding transcription factor activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Regulatory factor X, 4 (influences HLA class II expression) — cell component (P681): nucleus. GOA. Retrieved 2018-03-27. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Regulatory factor X, 4 (influences HLA class II expression) — cell component (P681): nucleus. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Regulatory factor X, 4 (influences HLA class II expression) — biological process (P682): regulation of transcription by RNA polymerase II. G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator. Retrieved 2018-03-27. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Regulatory factor X, 4 (influences HLA class II expression) — biological process (P682): forebrain development. Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4. Retrieved 2018-03-27. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Regulatory factor X, 4 (influences HLA class II expression) — biological process (P682): telencephalon development. The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Regulatory factor X, 4 (influences HLA class II expression) — biological process (P682): dorsal spinal cord development. Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4. Retrieved 2018-03-27. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Regulatory factor X, 4 (influences HLA class II expression) — biological process (P682): regulation of transcription, DNA-templated. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Regulatory factor X, 4 (influences HLA class II expression) — biological process (P682): negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning. The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis. Retrieved 2018-03-27. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Regulatory factor X, 4 (influences HLA class II expression) is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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BibTeX

@misc{4ortxyz_regulatory-factor-x-4-influences-hla-class-ii-expression-_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Regulatory factor X, 4 (influences HLA class II expression)}}, year = {2026}, url = {https://4ort.xyz/entity/regulatory-factor-x-4-influences-hla-class-ii-expression-}, note = {Accessed: 2026-05-03}}

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