RB binding protein 8, endonuclease

mammalian protein found in Homo sapiens

Protein protein Q21100486

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RB binding protein 8, endonuclease

Summary

RB binding protein 8, endonuclease is a protein^[1].

Key Facts

RB binding protein 8, endonuclease's instance of is recorded as protein^[2].
RB binding protein 8, endonuclease's UniProt protein ID is recorded as U4^[3].
RB binding protein 8, endonuclease's part of is recorded as DNA endonuclease RBBP8^[4].
RB binding protein 8, endonuclease's part of is recorded as DNA endonuclease Ctp1, N-terminal domain, protein family^[5].
RB binding protein 8, endonuclease's part of is recorded as DNA endonuclease Ctp1, C-terminal domain, protein family^[6].
RB binding protein 8, endonuclease's has part is recorded as DNA endonuclease Ctp1, C-terminal^[7].
RB binding protein 8, endonuclease's has part is recorded as DNA endonuclease Ctp1, N-terminal^[8].
RB binding protein 8, endonuclease's RefSeq protein ID is recorded as NP_002885^[9].
RB binding protein 8, endonuclease's RefSeq protein ID is recorded as NP_976036^[10].
RB binding protein 8, endonuclease's RefSeq protein ID is recorded as NP_976037^[11].
RB binding protein 8, endonuclease's RefSeq protein ID is recorded as XP_005258382^[12].
RB binding protein 8, endonuclease's RefSeq protein ID is recorded as XP_005258383^[13].
RB binding protein 8, endonuclease's RefSeq protein ID is recorded as XP_006722582^[14].
RB binding protein 8, endonuclease's RefSeq protein ID is recorded as XP_006722583^[15].
RB binding protein 8, endonuclease's RefSeq protein ID is recorded as XP_006722584^[16].
RB binding protein 8, endonuclease's RefSeq protein ID is recorded as XP_011524434^[17].
RB binding protein 8, endonuclease's RefSeq protein ID is recorded as XP_016881405^[18].
RB binding protein 8, endonuclease's RefSeq protein ID is recorded as XP_024307001^[19].
RB binding protein 8, endonuclease's PDB structure ID is recorded as 2L4Z^[20].
RB binding protein 8, endonuclease's PDB structure ID is recorded as 4D2H^[21].
RB binding protein 8, endonuclease's molecular function is recorded as nuclease activity^[22].
RB binding protein 8, endonuclease's molecular function is recorded as hydrolase activity^[23].
RB binding protein 8, endonuclease's molecular function is recorded as endonuclease activity^[24].
RB binding protein 8, endonuclease's molecular function is recorded as transcription corepressor activity^[25].
RB binding protein 8, endonuclease's molecular function is recorded as damaged DNA binding^[26].

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Quick Facts

Instance of protein

Part of DNA endonuclease RBBP8, DNA endonuclease Ctp1, N-terminal domain, protein family, DNA endonuclease Ctp1, C-terminal domain, protein family

Properties

Biological process cell cycle, DNA repair, nucleotide-excision repair, cell division, nucleic acid phosphodiester bond hydrolysis, response to estradiol, meiosis, regulation of transcription by RNA polymerase II, cellular response to DNA damage stimulus, blastocyst hatching, DNA double-strand break processing, DNA replication, DNA double-strand break processing involved in repair via single-strand annealing, negative regulation of transcription by RNA polymerase II, double-strand break repair via homologous recombination, negative regulation of G0 to G1 transition, negative regulation of nucleic acid-templated transcription, G1/S transition of mitotic cell cycle, double-strand break repair via homologous recombination, nucleotide-excision repair, DNA double-strand break processing involved in repair via single-strand annealing, regulation of signal transduction by p53 class mediator

Cell component transcription repressor complex, chromosome, nucleus, nucleoplasm, intracellular membrane-bounded organelle, site of double-strand break

Encoded by RBBP8

Found in taxon Homo sapiens

Has part(s) DNA endonuclease Ctp1, C-terminal, DNA endonuclease Ctp1, N-terminal

Imported from wholeness_audit_2026-05-02

Molecular function nuclease activity, hydrolase activity, endonuclease activity, transcription corepressor activity, damaged DNA binding, DNA binding, protein binding, single-stranded DNA endodeoxyribonuclease activity, identical protein binding, single-stranded DNA endodeoxyribonuclease activity, Y-form DNA binding, double-strand/single-strand DNA junction binding, damaged DNA binding, double-stranded DNA binding, single-stranded DNA binding, flap-structured DNA binding

External References (4)

Ensembl protein id ENSP00000323050, ENSP00000382628, ENSP00000382630, ENSP00000354024, ENSP00000382627, ENSP00000462390, ENSP00000463310, ENSP00000463439, ENSP00000463544, ENSP00000463738, ENSP00000464284, ENSP00000464628, ENSP00000464691, ENSP00000477396

Pdb structure id 2L4Z, 4D2H

Refseq protein id NP_002885, NP_976036, NP_976037, XP_005258382, XP_005258383, XP_006722582, XP_006722583, XP_006722584, XP_011524434, XP_016881405, XP_024307001

Uniprot protein id U4

🏷️ Also known as

en CTBP-interacting protein en CtIP en DNA endonuclease RBBP8 en RB binding protein 8, endonuclease en RBBP-8 en RBBP8 en retinoblastoma binding protein 8 en Retinoblastoma-binding protein 8 en Retinoblastoma-interacting protein and myosin-like en RIM en SAE2 en sporulation in the absence of SPO11 protein 2 homolog

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ RB binding protein 8, endonuclease — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ RB binding protein 8, endonuclease — UniProt protein ID (P352): U4. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ RB binding protein 8, endonuclease — part of (P361): DNA endonuclease RBBP8. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ RB binding protein 8, endonuclease — part of (P361): DNA endonuclease Ctp1, N-terminal domain, protein family. wikidata.org.
[6] ↑ RB binding protein 8, endonuclease — part of (P361): DNA endonuclease Ctp1, C-terminal domain, protein family. wikidata.org.
[7] ↑ RB binding protein 8, endonuclease — has part(s) (P527): DNA endonuclease Ctp1, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ RB binding protein 8, endonuclease — has part(s) (P527): DNA endonuclease Ctp1, N-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ RB binding protein 8, endonuclease — RefSeq protein ID (P637): NP_002885. Q20641742. Retrieved 2020-05-30. wikidata.org.
[10] ↑ RB binding protein 8, endonuclease — RefSeq protein ID (P637): NP_976036. Q20641742. Retrieved 2020-05-30. wikidata.org.
[11] ↑ RB binding protein 8, endonuclease — RefSeq protein ID (P637): NP_976037. Q20641742. Retrieved 2020-05-30. wikidata.org.
[12] ↑ RB binding protein 8, endonuclease — RefSeq protein ID (P637): XP_005258382. Q20641742. Retrieved 2020-05-30. wikidata.org.
[13] ↑ RB binding protein 8, endonuclease — RefSeq protein ID (P637): XP_005258383. Q20641742. Retrieved 2020-05-30. wikidata.org.
[14] ↑ RB binding protein 8, endonuclease — RefSeq protein ID (P637): XP_006722582. Q20641742. Retrieved 2020-05-30. wikidata.org.
[15] ↑ RB binding protein 8, endonuclease — RefSeq protein ID (P637): XP_006722583. Q20641742. Retrieved 2020-05-30. wikidata.org.
[16] ↑ RB binding protein 8, endonuclease — RefSeq protein ID (P637): XP_006722584. Q20641742. Retrieved 2020-05-30. wikidata.org.
[17] ↑ RB binding protein 8, endonuclease — RefSeq protein ID (P637): XP_011524434. Q20641742. Retrieved 2020-05-30. wikidata.org.
[18] ↑ RB binding protein 8, endonuclease — RefSeq protein ID (P637): XP_016881405. Q20641742. Retrieved 2020-05-30. wikidata.org.
[19] ↑ RB binding protein 8, endonuclease — RefSeq protein ID (P637): XP_024307001. Q20641742. Retrieved 2020-05-30. wikidata.org.
[20] ↑ RB binding protein 8, endonuclease — PDB structure ID (P638): 2L4Z. Q905695. Retrieved 2016-08-04. wikidata.org.
[21] ↑ RB binding protein 8, endonuclease — PDB structure ID (P638): 4D2H. Q905695. Retrieved 2016-08-04. wikidata.org.
[22] ↑ RB binding protein 8, endonuclease — molecular function (P680): nuclease activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ RB binding protein 8, endonuclease — molecular function (P680): hydrolase activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ RB binding protein 8, endonuclease — molecular function (P680): endonuclease activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ RB binding protein 8, endonuclease — molecular function (P680): transcription corepressor activity. RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ RB binding protein 8, endonuclease — molecular function (P680): damaged DNA binding. CDK targets Sae2 to control DNA-end resection and homologous recombination. Retrieved 2018-07-16. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ RB binding protein 8, endonuclease is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). RB binding protein 8, endonuclease. Retrieved May 3, 2026, from https://4ort.xyz/entity/rb-binding-protein-8-endonuclease

MLA

“RB binding protein 8, endonuclease.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/rb-binding-protein-8-endonuclease.

BibTeX

@misc{4ortxyz_rb-binding-protein-8-endonuclease_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{RB binding protein 8, endonuclease}}, year = {2026}, url = {https://4ort.xyz/entity/rb-binding-protein-8-endonuclease}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): RB binding protein 8, endonuclease — https://4ort.xyz/entity/rb-binding-protein-8-endonuclease (retrieved 2026-05-03)

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