R-spondin 2

mammalian protein found in Mus musculus

Protein protein Q21988502

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Summary

R-spondin 2 is a protein^[1].

Key Facts

R-spondin 2's instance of is recorded as protein^[2].
R-spondin 2's subclass of is recorded as protein^[3].
R-spondin 2's UniProt protein ID is recorded as Q8BFU0^[4].
R-spondin 2's part of is recorded as Thrombospondin type-1 (TSP1) repeat superfamily^[5].
R-spondin 2's part of is recorded as Growth factor receptor cysteine-rich domain superfamily^[6].
R-spondin 2's part of is recorded as Thrombospondin type-1 (TSP1) repeat, protein family^[7].
R-spondin 2's part of is recorded as Furin-like repeat, protein family^[8].
R-spondin 2's has part is recorded as Furin-like repeat^[9].
R-spondin 2's has part is recorded as Thrombospondin type-1 (TSP1) repeat^[10].
R-spondin 2's RefSeq protein ID is recorded as NP_766403^[11].
R-spondin 2's RefSeq protein ID is recorded as XP_011243909^[12].
R-spondin 2's RefSeq protein ID is recorded as XP_011243911^[13].
R-spondin 2's RefSeq protein ID is recorded as XP_017172085^[14].
R-spondin 2's RefSeq protein ID is recorded as NP_001344885^[15].
R-spondin 2's RefSeq protein ID is recorded as NP_001344886^[16].
R-spondin 2's RefSeq protein ID is recorded as XP_030104398^[17].
R-spondin 2's RefSeq protein ID is recorded as XP_036015286^[18].
R-spondin 2's RefSeq protein ID is recorded as XP_036015287^[19].
R-spondin 2's PDB structure ID is recorded as 4C99^[20].
R-spondin 2's PDB structure ID is recorded as 4UFR^[21].
R-spondin 2's PDB structure ID is recorded as 4UFS^[22].
R-spondin 2's molecular function is recorded as heparin binding^[23].
R-spondin 2's molecular function is recorded as signaling receptor binding^[24].
R-spondin 2's molecular function is recorded as frizzled binding^[25].
R-spondin 2's cell component is recorded as extracellular region^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of Thrombospondin type-1 (TSP1) repeat superfamily, Growth factor receptor cysteine-rich domain superfamily, Thrombospondin type-1 (TSP1) repeat, protein family, Furin-like repeat, protein family

Properties

Biological process positive regulation of canonical Wnt signaling pathway, bone mineralization, lung growth, dopaminergic neuron differentiation, epithelial tube branching involved in lung morphogenesis, Wnt signaling pathway, embryonic forelimb morphogenesis, negative regulation of odontogenesis of dentin-containing tooth, osteoblast differentiation, response to stimulus, trachea cartilage morphogenesis, embryonic hindlimb morphogenesis, positive regulation of canonical Wnt signaling pathway, positive regulation of Wnt signaling pathway, limb development, multicellular organism development, positive regulation of Wnt signaling pathway, limb development

Cell component extracellular region, cell surface, extracellular space

Encoded by Rspo2

Found in taxon house mouse

Has part(s) Furin-like repeat, Thrombospondin type-1 (TSP1) repeat

Imported from wholeness_audit_2026-05-02

Molecular function heparin binding, signaling receptor binding, frizzled binding

External References (4)

Ensembl protein id ENSMUSP00000067325, ENSMUSP00000154600

Pdb structure id 4C99, 4UFR, 4UFS

Refseq protein id NP_766403, XP_011243909, XP_011243911, XP_017172085, NP_001344885, NP_001344886, XP_030104398, XP_036015286, XP_036015287

Uniprot protein id Q8BFU0

🏷️ Also known as

en cristin-2 en cysteine-rich and single thrombospondin domain-containing protein 2 en mCristin-2 en roof plate-specific spondin-2 en Rspo2 en R-spondin 2 en R-spondin-2 en R-spondin 2 homolog

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ R-spondin 2 — instance of (P31): protein. UniProt. Retrieved 2022-05-25. wikidata.org.
[3] ↑ R-spondin 2 — subclass of (P279): protein. UniProt. Retrieved 2017-01-19. wikidata.org.
[4] ↑ R-spondin 2 — UniProt protein ID (P352): Q8BFU0. UniProt. Retrieved 2022-05-25. wikidata.org.
[5] ↑ R-spondin 2 — part of (P361): Thrombospondin type-1 (TSP1) repeat superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ R-spondin 2 — part of (P361): Growth factor receptor cysteine-rich domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ R-spondin 2 — part of (P361): Thrombospondin type-1 (TSP1) repeat, protein family. wikidata.org.
[8] ↑ R-spondin 2 — part of (P361): Furin-like repeat, protein family. wikidata.org.
[9] ↑ R-spondin 2 — has part(s) (P527): Furin-like repeat. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ R-spondin 2 — has part(s) (P527): Thrombospondin type-1 (TSP1) repeat. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ R-spondin 2 — RefSeq protein ID (P637): NP_766403. Q20641742. Retrieved 2022-03-20. wikidata.org.
[12] ↑ R-spondin 2 — RefSeq protein ID (P637): XP_011243909. Q20641742. Retrieved 2022-03-20. wikidata.org.
[13] ↑ R-spondin 2 — RefSeq protein ID (P637): XP_011243911. Q20641742. Retrieved 2022-03-20. wikidata.org.
[14] ↑ R-spondin 2 — RefSeq protein ID (P637): XP_017172085. Q20641742. Retrieved 2022-03-20. wikidata.org.
[15] ↑ R-spondin 2 — RefSeq protein ID (P637): NP_001344885. Q20641742. Retrieved 2022-03-20. wikidata.org.
[16] ↑ R-spondin 2 — RefSeq protein ID (P637): NP_001344886. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ R-spondin 2 — RefSeq protein ID (P637): XP_030104398. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ R-spondin 2 — RefSeq protein ID (P637): XP_036015286. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ R-spondin 2 — RefSeq protein ID (P637): XP_036015287. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ R-spondin 2 — PDB structure ID (P638): 4C99. UniProt. Retrieved 2016-03-20. wikidata.org.
[21] ↑ R-spondin 2 — PDB structure ID (P638): 4UFR. UniProt. Retrieved 2016-03-20. wikidata.org.
[22] ↑ R-spondin 2 — PDB structure ID (P638): 4UFS. UniProt. Retrieved 2016-03-20. wikidata.org.
[23] ↑ R-spondin 2 — molecular function (P680): heparin binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ R-spondin 2 — molecular function (P680): signaling receptor binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ R-spondin 2 — molecular function (P680): frizzled binding. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ R-spondin 2 — cell component (P681): extracellular region. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ R-spondin 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). R-spondin 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/r-spondin-2-q21988502

MLA “R-spondin 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/r-spondin-2-q21988502.

BibTeX

@misc{4ortxyz_r-spondin-2-q21988502_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{R-spondin 2}}, year = {2026}, url = {https://4ort.xyz/entity/r-spondin-2-q21988502}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): R-spondin 2 — https://4ort.xyz/entity/r-spondin-2-q21988502 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/r-spondin-2-q21988502 · Last refreshed: May 3, 2026