R-spondin 2

mammalian protein found in Homo sapiens
Protein protein Q21120717

Facts

9 properties
Instance of
protein
Part of
Thrombospondin type-1 (TSP1) repeat superfamily, Growth factor receptor cysteine-rich domain superfamily, Thrombospondin type-1 (TSP1) repeat, protein family, Furin-like repeat, protein family[2][3][4][5]
Biological process
positive regulation of canonical Wnt signaling pathway, positive regulation of Wnt signaling pathway, bone mineralization, lung growth, dopaminergic neuron differentiation, epithelial tube branching involved in lung morphogenesis, Wnt signaling pathway, embryonic forelimb morphogenesis, negative regulation of odontogenesis of dentin-containing tooth, osteoblast differentiation, response to stimulus, trachea cartilage morphogenesis, embryonic hindlimb morphogenesis, positive regulation of canonical Wnt signaling pathway, multicellular organism development, positive regulation of Wnt signaling pathway, limb development[15][16][17][18]
Encoded by
RSPO2
Found in taxon
Homo sapiens
Has part(s)
Thrombospondin type-1 (TSP1) repeat, Furin-like repeat[6][7]
Imported from
wholeness_audit_2026-05-02
Molecular function
heparin binding, signaling receptor binding, protein binding, frizzled binding[8][9][10][11]
🏷️ Also known as
en hRspo2 en roof plate-specific spondin-2 en RSPO2 en R-spondin 2 en R-spondin-2 en R-spondin 2 homolog

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Summary

R-spondin 2 is a protein[1].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [4] ↑ . wikidata.org.
  4. [5] ↑ . wikidata.org.
  5. [6] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [7] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  7. [8] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [9] ↑ . LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [10] ↑ . RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [11] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [12] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [14] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [16] ↑ . Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). R-spondin 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/r-spondin-2
MLA “R-spondin 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/r-spondin-2.
BibTeX @misc{4ortxyz_r-spondin-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{R-spondin 2}}, year = {2026}, url = {https://4ort.xyz/entity/r-spondin-2}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): R-spondin 2 — https://4ort.xyz/entity/r-spondin-2 (retrieved 2026-05-03)

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