R-spondin 1

mammalian protein found in Homo sapiens

Protein protein Q21124389

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Summary

R-spondin 1 is a protein^[1].

Key Facts

Part of: Thrombospondin type-1 (TSP1) repeat superfamily^[2], Growth factor receptor cysteine-rich domain superfamily^[3], Thrombospondin type-1 (TSP1) repeat, protein family^[4], Furin-like repeat, protein family^[5]
Has part(s): Thrombospondin type-1 (TSP1) repeat^[6], Furin-like repeat^[7]
Molecular function: heparin binding^[8]

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Quick Facts

Instance of protein

Part of Thrombospondin type-1 (TSP1) repeat superfamily, Growth factor receptor cysteine-rich domain superfamily, Thrombospondin type-1 (TSP1) repeat, protein family, Furin-like repeat, protein family

Properties

Biological process positive regulation of canonical Wnt signaling pathway, positive regulation of Wnt signaling pathway, regulation of receptor internalization, positive regulation of protein phosphorylation, Wnt signaling pathway, response to stimulus, positive regulation of canonical Wnt signaling pathway

Cell component extracellular region, nucleus, extracellular space

Encoded by RSPO1

Found in taxon Homo sapiens

Has part(s) Thrombospondin type-1 (TSP1) repeat, Furin-like repeat

Imported from wholeness_audit_2026-05-02

Molecular function heparin binding, signaling receptor binding, protein binding, G protein-coupled receptor binding, frizzled binding

Identifiers (4)

Ensembl protein id ENSP00000348944, ENSP00000383846, ENSP00000479832, ENSP00000481178

Pdb structure id 4BSO, 4BSP, 4BSR, 4BSS, 4BST, 4BSU, 4CDK, 4KNG, 4KT1, 4LI2, 4QXF

Refseq protein id NP_001033722, NP_001229837, NP_001229838, NP_001229839, XP_006710646

Uniprot protein id Q2MKA7

🏷️ Also known as

en hRspo1 en roof plate-specific spondin-1 en RSPO1 en R-spondin 1 en R-spondin-1 en R-spondin homolog

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ R-spondin 1 — part of (P361): Thrombospondin type-1 (TSP1) repeat superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[3] ↑ R-spondin 1 — part of (P361): Growth factor receptor cysteine-rich domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[4] ↑ R-spondin 1 — part of (P361): Thrombospondin type-1 (TSP1) repeat, protein family. wikidata.org.
[5] ↑ R-spondin 1 — part of (P361): Furin-like repeat, protein family. wikidata.org.
[6] ↑ R-spondin 1 — has part(s) (P527): Thrombospondin type-1 (TSP1) repeat. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ R-spondin 1 — has part(s) (P527): Furin-like repeat. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ R-spondin 1 — molecular function (P680): heparin binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ R-spondin 1 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). R-spondin 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/r-spondin-1-q21124389

MLA “R-spondin 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/r-spondin-1-q21124389.

BibTeX

@misc{4ortxyz_r-spondin-1-q21124389_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{R-spondin 1}}, year = {2026}, url = {https://4ort.xyz/entity/r-spondin-1-q21124389}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): R-spondin 1 — https://4ort.xyz/entity/r-spondin-1-q21124389 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/r-spondin-1-q21124389 · Last refreshed: May 3, 2026