Pyruvate dehydrogenase kinase 2

mammalian protein found in Homo sapiens
Protein protein Q21123214
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Summary

Pyruvate dehydrogenase kinase 2 is a protein[1]. It is known by 10 alternative names across languages and contexts.[2]

Key Facts

  • Pyruvate dehydrogenase kinase 2's instance of is recorded as protein[3].
  • Pyruvate dehydrogenase kinase 2's molecular function is recorded as transferase activity[4].
  • Pyruvate dehydrogenase kinase 2's molecular function is recorded as nucleotide binding[5].
  • Pyruvate dehydrogenase kinase 2's molecular function is recorded as protein kinase activity[6].
  • Pyruvate dehydrogenase kinase 2's molecular function is recorded as protein homodimerization activity[7].
  • Pyruvate dehydrogenase kinase 2's molecular function is recorded as kinase activity[8].
  • Pyruvate dehydrogenase kinase 2's molecular function is recorded as ATP binding[9].
  • Pyruvate dehydrogenase kinase 2's molecular function is recorded as pyruvate dehydrogenase (acetyl-transferring) kinase activity[10].
  • Pyruvate dehydrogenase kinase 2's molecular function is recorded as protein kinase activity[11].
  • Pyruvate dehydrogenase kinase 2's molecular function is recorded as pyruvate dehydrogenase (acetyl-transferring) kinase activity[12].
  • Pyruvate dehydrogenase kinase 2's cell component is recorded as nucleoplasm[13].
  • Pyruvate dehydrogenase kinase 2's cell component is recorded as mitochondrial matrix[14].
  • Pyruvate dehydrogenase kinase 2's cell component is recorded as mitochondrion[15].
  • Pyruvate dehydrogenase kinase 2's cell component is recorded as mitochondrial pyruvate dehydrogenase complex[16].
  • Pyruvate dehydrogenase kinase 2's cell component is recorded as cytosol[17].
  • Pyruvate dehydrogenase kinase 2's biological process is recorded as phosphorylation[18].
  • Pyruvate dehydrogenase kinase 2's biological process is recorded as cellular response to reactive oxygen species[19].
  • Pyruvate dehydrogenase kinase 2's biological process is recorded as intrinsic apoptotic signaling pathway by p53 class mediator[20].
  • Pyruvate dehydrogenase kinase 2's biological process is recorded as glucose metabolic process[21].
  • Pyruvate dehydrogenase kinase 2's biological process is recorded as regulation of acetyl-CoA biosynthetic process from pyruvate[22].
  • Pyruvate dehydrogenase kinase 2's biological process is recorded as cellular response to nutrient[23].
  • Pyruvate dehydrogenase kinase 2's biological process is recorded as insulin receptor signaling pathway[24].
  • Pyruvate dehydrogenase kinase 2's biological process is recorded as regulation of cellular ketone metabolic process[25].
  • Pyruvate dehydrogenase kinase 2's biological process is recorded as regulation of glucose metabolic process[26].
  • Pyruvate dehydrogenase kinase 2's biological process is recorded as glucose homeostasis[27].

Why It Matters

Pyruvate dehydrogenase kinase 2 is known by 10 alternative names across languages and contexts.[2]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . UniProt. Retrieved . wikidata.org.
  2. [4] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  3. [5] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  4. [6] ↑ . Marked differences between two isoforms of human pyruvate dehydrogenase kinase. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  5. [7] ↑ . Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  6. [8] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  7. [9] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [10] ↑ . Diversity of the pyruvate dehydrogenase kinase gene family in humans. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [11] ↑ . Diversity of the pyruvate dehydrogenase kinase gene family in humans. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [12] ↑ . Diversity of the pyruvate dehydrogenase kinase gene family in humans. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [14] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] ↑ . Chronic CSE treatment induces the growth of normal oral keratinocytes via PDK2 upregulation, increased glycolysis and HIF1α stabilization. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] ↑ . p53 Negatively Regulates Transcription of the Pyruvate Dehydrogenase Kinase Pdk2. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] ↑ . Diversity of the pyruvate dehydrogenase kinase gene family in humans. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikidata aliases. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Pyruvate dehydrogenase kinase 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/pyruvate-dehydrogenase-kinase-2
MLA “Pyruvate dehydrogenase kinase 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/pyruvate-dehydrogenase-kinase-2.
BibTeX @misc{4ortxyz_pyruvate-dehydrogenase-kinase-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Pyruvate dehydrogenase kinase 2}}, year = {2026}, url = {https://4ort.xyz/entity/pyruvate-dehydrogenase-kinase-2}, note = {Accessed: 2026-05-03}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 11w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from → —
    Encoded by → PDK2
    Wikidata description → mammalian protein found in Homo sapiens
    Molecular function → transferase activity, nucleotide binding, protein kinase activity +6
    + 11 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 2.7.11.2, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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