Pyrroline-5-carboxylate reductase 2

mammalian protein found in Homo sapiens
Protein protein Q21119673
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Summary

Pyrroline-5-carboxylate reductase 2 is a protein[1].

Key Facts

  • Pyrroline-5-carboxylate reductase 2's instance of is recorded as protein[2].
  • Pyrroline-5-carboxylate reductase 2 is part of 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily[3].
  • Pyrroline-5-carboxylate reductase 2 is part of NAD(P)-binding domain superfamily[4].
  • Pyrroline-5-carboxylate reductase 2 is part of Pyrroline-5-carboxylate reductase[5].
  • Pyrroline-5-carboxylate reductase 2 is part of Pyrroline-5-carboxylate reductase, dimerisation domain, protein family[6].
  • Pyrroline-5-carboxylate reductase 2 is part of Pyrroline-5-carboxylate reductase, catalytic, N-terminal domain, protein family[7].
  • Pyrroline-5-carboxylate reductase 2 comprises Pyrroline-5-carboxylate reductase, dimerisation domain[8].
  • Pyrroline-5-carboxylate reductase 2 comprises Pyrroline-5-carboxylate reductase, catalytic, N-terminal[9].
  • Pyrroline-5-carboxylate reductase 2's molecular function is recorded as pyrroline-5-carboxylate reductase activity[10].
  • Pyrroline-5-carboxylate reductase 2's molecular function is recorded as oxidoreductase activity[11].
  • Pyrroline-5-carboxylate reductase 2's molecular function is recorded as protein binding[12].
  • Pyrroline-5-carboxylate reductase 2's molecular function is recorded as pyrroline-5-carboxylate reductase activity[13].
  • Pyrroline-5-carboxylate reductase 2's molecular function is recorded as pyrroline-5-carboxylate reductase activity[14].
  • Pyrroline-5-carboxylate reductase 2's cell component is recorded as mitochondrial matrix[15].
  • Pyrroline-5-carboxylate reductase 2's cell component is recorded as cytoplasm[16].
  • Pyrroline-5-carboxylate reductase 2's cell component is recorded as mitochondrion[17].
  • Pyrroline-5-carboxylate reductase 2's biological process is recorded as L-proline biosynthetic process[18].
  • Pyrroline-5-carboxylate reductase 2's biological process is recorded as cellular response to oxidative stress[19].
  • Pyrroline-5-carboxylate reductase 2's biological process is recorded as proline biosynthetic process[20].
  • Pyrroline-5-carboxylate reductase 2's biological process is recorded as cellular amino acid biosynthetic process[21].
  • Pyrroline-5-carboxylate reductase 2's biological process is recorded as L-proline biosynthetic process[22].
  • Pyrroline-5-carboxylate reductase 2's encoded by is recorded as PYCR2[23].
  • Pyrroline-5-carboxylate reductase 2's found in taxon is recorded as Homo sapiens[24].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . UniProt. Retrieved . wikidata.org.
  2. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [5] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  5. [6] ↑ . wikidata.org.
  6. [7] ↑ . wikidata.org.
  7. [8] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  8. [9] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  9. [10] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [11] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [12] ↑ . Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production.. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [14] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [19] ↑ . Mutations in PYCR2, Encoding Pyrroline-5-Carboxylate Reductase 2, Cause Microcephaly and Hypomyelination. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [21] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [23] ↑ . UniProt. Retrieved . wikidata.org.
  23. [24] ↑ . UniProt. Retrieved . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

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APA 4ort.xyz Knowledge Graph. (2026). Pyrroline-5-carboxylate reductase 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/pyrroline-5-carboxylate-reductase-2
MLA “Pyrroline-5-carboxylate reductase 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/pyrroline-5-carboxylate-reductase-2.
BibTeX @misc{4ortxyz_pyrroline-5-carboxylate-reductase-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Pyrroline-5-carboxylate reductase 2}}, year = {2026}, url = {https://4ort.xyz/entity/pyrroline-5-carboxylate-reductase-2}, note = {Accessed: 2026-05-03}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 12w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from → —
    Encoded by → PYCR2
    Wikidata description → mammalian protein found in Homo sapiens
    Molecular function → pyrroline-5-carboxylate reductase activity, oxidoreductase activity, protein binding +2
    + 10 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 1.5.1.2, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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