PYD and CARD domain containing

mammalian protein found in Homo sapiens

Protein protein Q21116456

Press Enter · cited answer in seconds

PYD and CARD domain containing

Summary

PYD and CARD domain containing is a protein^[1].

Key Facts

PYD and CARD domain containing's instance of is recorded as protein^[2].
PYD and CARD domain containing's UniProt protein ID is recorded as Q9ULZ3^[3].
PYD and CARD domain containing's RefSeq protein ID is recorded as NP_037390^[4].
PYD and CARD domain containing's RefSeq protein ID is recorded as NP_660183^[5].
PYD and CARD domain containing's PDB structure ID is recorded as 1UCP^[6].
PYD and CARD domain containing's PDB structure ID is recorded as 2KN6^[7].
PYD and CARD domain containing's PDB structure ID is recorded as 3J63^[8].
PYD and CARD domain containing's PDB structure ID is recorded as 5H8O^[9].
PYD and CARD domain containing's molecular function is recorded as protein homodimerization activity^[10].
PYD and CARD domain containing's molecular function is recorded as interleukin-6 receptor binding^[11].
PYD and CARD domain containing's molecular function is recorded as BMP receptor binding^[12].
PYD and CARD domain containing's molecular function is recorded as protein binding^[13].
PYD and CARD domain containing's molecular function is recorded as identical protein binding^[14].
PYD and CARD domain containing's molecular function is recorded as enzyme binding^[15].
PYD and CARD domain containing's molecular function is recorded as cysteine-type endopeptidase activity involved in apoptotic process^[16].
PYD and CARD domain containing's molecular function is recorded as Pyrin domain binding^[17].
PYD and CARD domain containing's molecular function is recorded as cysteine-type endopeptidase activator activity involved in apoptotic process^[18].
PYD and CARD domain containing's molecular function is recorded as myosin I binding^[19].
PYD and CARD domain containing's molecular function is recorded as tropomyosin binding^[20].
PYD and CARD domain containing's molecular function is recorded as protease binding^[21].
PYD and CARD domain containing's molecular function is recorded as protease binding^[22].
PYD and CARD domain containing's molecular function is recorded as transmembrane transporter binding^[23].
PYD and CARD domain containing's molecular function is recorded as protein dimerization activity^[24].
PYD and CARD domain containing's molecular function is recorded as cysteine-type endopeptidase activity^[25].
PYD and CARD domain containing's cell component is recorded as cytoplasm^[26].

⭐ Popularity Graph

0/100 long tail

Quick Facts

Instance of protein

Properties

Biological process positive regulation of cysteine-type endopeptidase activity, regulation of apoptotic process, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, regulation of intrinsic apoptotic signaling pathway, intrinsic apoptotic signaling pathway by p53 class mediator, positive regulation of adaptive immune response, defense response to Gram-negative bacterium, immune system process, cellular response to tumor necrosis factor, regulation of tumor necrosis factor-mediated signaling pathway, positive regulation of DNA-binding transcription factor activity, tumor necrosis factor-mediated signaling pathway, positive regulation of JNK cascade, negative regulation of interferon-beta production, negative regulation of I-kappaB kinase/NF-kappaB signaling, myeloid dendritic cell activation, positive regulation of T cell activation, defense response to virus, cellular response to interleukin-1, positive regulation of apoptotic process, positive regulation of tumor necrosis factor production, positive regulation of release of cytochrome c from mitochondria, negative regulation of protein serine/threonine kinase activity, positive regulation of extrinsic apoptotic signaling pathway, inflammatory response, cellular response to lipopolysaccharide, negative regulation of NF-kappaB transcription factor activity, signal transduction, apoptotic process, innate immune response, neutrophil degranulation, positive regulation of NF-kappaB transcription factor activity, activation of innate immune response, myeloid dendritic cell activation involved in immune response, positive regulation of antigen processing and presentation of peptide antigen via MHC class II, activation of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of actin filament polymerization, regulation of protein stability, positive regulation of interferon-gamma production, positive regulation of interleukin-6 production, positive regulation of activated T cell proliferation, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, macropinocytosis, positive regulation of phagocytosis, positive regulation of ERK1 and ERK2 cascade, positive regulation of T cell migration, activation of innate immune response, positive regulation of defense response to virus by host, myeloid dendritic cell activation involved in immune response, positive regulation of antigen processing and presentation of peptide antigen via MHC class II, apoptotic process, activation of cysteine-type endopeptidase activity involved in apoptotic process, intrinsic apoptotic signaling pathway in response to DNA damage, response to bacterium, regulation of autophagy, positive regulation of actin filament polymerization, regulation of protein stability, interleukin-1 beta production, positive regulation of interferon-gamma production, positive regulation of interleukin-6 production, positive regulation of activated T cell proliferation, regulation of GTPase activity, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, regulation of cysteine-type endopeptidase activity involved in apoptotic process, macropinocytosis, regulation of inflammatory response, positive regulation of phagocytosis, protein homooligomerization, positive regulation of ERK1 and ERK2 cascade, activation of cysteine-type endopeptidase activity, negative regulation of cytokine production involved in inflammatory response, positive regulation of T cell migration, proteolysis, positive regulation of interleukin-1 beta production, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

Cell component cytoplasm, NLRP3 inflammasome complex, NLRP1 inflammasome complex, AIM2 inflammasome complex, nucleolus, endoplasmic reticulum, mitochondrion, IkappaB kinase complex, nucleus, secretory granule lumen, azurophil granule lumen, extracellular region, cytosol, extracellular region, cytoplasm, cytosol, protein-containing complex, soma, Golgi membrane, Golgi membrane, Golgi apparatus, membrane, protein-containing complex

Encoded by PYCARD

Found in taxon Homo sapiens

Imported from wholeness_audit_2026-05-02

Molecular function protein homodimerization activity, interleukin-6 receptor binding, BMP receptor binding, protein binding, identical protein binding, enzyme binding, cysteine-type endopeptidase activity involved in apoptotic process, Pyrin domain binding, cysteine-type endopeptidase activator activity involved in apoptotic process, myosin I binding, tropomyosin binding, protease binding, protease binding, transmembrane transporter binding, protein dimerization activity, cysteine-type endopeptidase activity

External References (4)

Ensembl protein id ENSP00000247470, ENSP00000340441, ENSP00000455141

Pdb structure id 1UCP, 2KN6, 3J63, 5H8O

Refseq protein id NP_037390, NP_660183

Uniprot protein id Q9ULZ3

🏷️ Also known as

en apoptosis-associated speck-like protein containing a CARD en caspase recruitment domain-containing protein 5 en PYCARD en PYD and CARD domain containing en PYD and CARD domain-containing protein en target of methylation-induced silencing 1

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ PYD and CARD domain containing — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ PYD and CARD domain containing — UniProt protein ID (P352): Q9ULZ3. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ PYD and CARD domain containing — RefSeq protein ID (P637): NP_037390. Q20641742. Retrieved 2020-05-30. wikidata.org.
[5] ↑ PYD and CARD domain containing — RefSeq protein ID (P637): NP_660183. Q20641742. Retrieved 2020-05-30. wikidata.org.
[6] ↑ PYD and CARD domain containing — PDB structure ID (P638): 1UCP. Q905695. Retrieved 2016-08-09. wikidata.org.
[7] ↑ PYD and CARD domain containing — PDB structure ID (P638): 2KN6. Q905695. Retrieved 2016-08-09. wikidata.org.
[8] ↑ PYD and CARD domain containing — PDB structure ID (P638): 3J63. Q905695. Retrieved 2016-08-09. wikidata.org.
[9] ↑ PYD and CARD domain containing — PDB structure ID (P638): 5H8O. Q905695. Retrieved 2016-08-09. wikidata.org.
[10] ↑ PYD and CARD domain containing — molecular function (P680): protein homodimerization activity. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ PYD and CARD domain containing — molecular function (P680): interleukin-6 receptor binding. Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ PYD and CARD domain containing — molecular function (P680): BMP receptor binding. Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ PYD and CARD domain containing — molecular function (P680): protein binding. PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ PYD and CARD domain containing — molecular function (P680): identical protein binding. Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ PYD and CARD domain containing — molecular function (P680): enzyme binding. Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ PYD and CARD domain containing — molecular function (P680): cysteine-type endopeptidase activity involved in apoptotic process. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ PYD and CARD domain containing — molecular function (P680): Pyrin domain binding. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ PYD and CARD domain containing — molecular function (P680): cysteine-type endopeptidase activator activity involved in apoptotic process. PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ PYD and CARD domain containing — molecular function (P680): myosin I binding. Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ PYD and CARD domain containing — molecular function (P680): tropomyosin binding. Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ PYD and CARD domain containing — molecular function (P680): protease binding. Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation. Retrieved 2018-03-27. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ PYD and CARD domain containing — molecular function (P680): protease binding. Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ PYD and CARD domain containing — molecular function (P680): transmembrane transporter binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ PYD and CARD domain containing — molecular function (P680): protein dimerization activity. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ PYD and CARD domain containing — molecular function (P680): cysteine-type endopeptidase activity. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ PYD and CARD domain containing — cell component (P681): cytoplasm. PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. Retrieved 2018-03-27. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ PYD and CARD domain containing is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). PYD and CARD domain containing. Retrieved May 3, 2026, from https://4ort.xyz/entity/pyd-and-card-domain-containing

MLA

“PYD and CARD domain containing.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/pyd-and-card-domain-containing.

BibTeX

@misc{4ortxyz_pyd-and-card-domain-containing_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{PYD and CARD domain containing}}, year = {2026}, url = {https://4ort.xyz/entity/pyd-and-card-domain-containing}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): PYD and CARD domain containing — https://4ort.xyz/entity/pyd-and-card-domain-containing (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/pyd-and-card-domain-containing · Last refreshed: May 3, 2026