Protein tyrosine kinase 6

mammalian protein found in Homo sapiens
Protein protein Q21114361
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Summary

Protein tyrosine kinase 6 is a protein[1]. It is known by 7 alternative names across languages and contexts.[2]

Key Facts

  • Part of: SH3-like domain superfamily[3], Protein kinase-like domain superfamily[4], SH2 domain superfamily[5], Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family[6], SH2 domain, protein family[7], PTK6, SH2 domain, protein family[8], SH3 domain, protein family[9], Protein kinase domain, protein family[10], Protein kinase, ATP binding site, protein family[11], Tyrosine-protein kinase, catalytic domain, protein family[12], Tyrosine-protein kinase, active site, protein family[13]
  • Has part(s): tyrosine-protein kinase, active site[14], SH3 domain[15], protein kinase, ATP binding site[16], protein kinase domain[17], tyrosine-protein kinase, catalytic domain[18], SH2 domain[19], serine-threonine/tyrosine-protein kinase, catalytic domain[20], PTK6, SH2 domain[21]
  • Molecular function: transferase activity[22], nucleotide binding[23], protein kinase activity[24], non-membrane spanning protein tyrosine kinase activity[25], kinase activity[26], protein binding[27], identical protein binding[28], signaling receptor binding[29], ATP binding[30], protein tyrosine kinase activity[31]
  • Cell component: cytoplasm[32], cell projection[33], membrane[34], ruffle[35], extrinsic component of cytoplasmic side of plasma membrane[36], nucleus[37], nucleoplasm[38], cytosol[39], plasma membrane[40], nuclear body[41]
  • Biological process: cellular response to retinoic acid[42], negative regulation of growth[43], phosphorylation[44], transmembrane receptor protein tyrosine kinase signaling pathway[45], protein phosphorylation[46], negative regulation of protein tyrosine kinase activity[47], regulation of cell population proliferation[48], intestinal epithelial cell differentiation[49], positive regulation of neuron projection development[50], peptidyl-tyrosine autophosphorylation[51], protein autophosphorylation[52], innate immune response[53], cell migration[54], positive regulation of cell cycle[55]
  • Encoded by: PTK6[56]
  • Found in taxon: Homo sapiens[57]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [5] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [6] ↑ . wikidata.org.
  5. [7] ↑ . wikidata.org.
  6. [8] ↑ . wikidata.org.
  7. [9] ↑ . wikidata.org.
  8. [10] ↑ . wikidata.org.
  9. [11] ↑ . wikidata.org.
  10. [12] ↑ . wikidata.org.
  11. [13] ↑ . wikidata.org.
  12. [14] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  13. [15] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  14. [16] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  15. [17] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  16. [18] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  17. [19] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  18. [20] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  19. [21] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  20. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] ↑ . Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] ↑ . Regulated association of protein kinase B/Akt with breast tumor kinase. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [28] ↑ . Brk is coamplified with ErbB2 to promote proliferation in breast cancer. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [29] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [30] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [31] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  30. [32] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  31. [33] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  32. [34] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  33. [35] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  34. [36] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  35. [37] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  36. [38] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  37. [39] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  38. [40] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  39. [41] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  40. [42] ↑ . Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  41. [43] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  42. [44] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  43. [45] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  44. [46] ↑ . Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  45. [47] ↑ . Regulated association of protein kinase B/Akt with breast tumor kinase. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  46. [48] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  47. [49] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  48. [50] ↑ . Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  49. [51] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  50. [52] ↑ . Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  51. [53] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  52. [54] ↑ . Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  53. [55] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  54. [56] ↑ . UniProt. Retrieved . wikidata.org.
  55. [57] ↑ . UniProt. Retrieved . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikidata aliases. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Protein tyrosine kinase 6. Retrieved May 3, 2026, from https://4ort.xyz/entity/protein-tyrosine-kinase-6
MLA “Protein tyrosine kinase 6.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/protein-tyrosine-kinase-6.
BibTeX @misc{4ortxyz_protein-tyrosine-kinase-6_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Protein tyrosine kinase 6}}, year = {2026}, url = {https://4ort.xyz/entity/protein-tyrosine-kinase-6}, note = {Accessed: 2026-05-03}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 12w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from → —
    Encoded by → PTK6
    Wikidata description → mammalian protein found in Homo sapiens
    Molecular function → transferase activity, nucleotide binding, protein kinase activity +8
    + 11 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 2.7.10.2, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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