Protein kinase, DNA-activated, catalytic subunit

mammalian protein found in Homo sapiens

Protein protein Q21105070

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Summary

Protein kinase, DNA-activated, catalytic subunit is a protein^[1]. It is known by 8 alternative names across languages and contexts.^[2]

Key Facts

Protein kinase, DNA-activated, catalytic subunit's instance of is recorded as protein^[3].
Protein kinase, DNA-activated, catalytic subunit is part of Protein kinase-like domain superfamily^[4].
Protein kinase, DNA-activated, catalytic subunit is part of Armadillo-type fold^[5].
Protein kinase, DNA-activated, catalytic subunit is part of Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily^[6].
Protein kinase, DNA-activated, catalytic subunit is part of Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family^[7].
Protein kinase, DNA-activated, catalytic subunit is part of DNA-dependent protein kinase catalytic subunit, catalytic domain, protein family^[8].
Protein kinase, DNA-activated, catalytic subunit is part of PIK-related kinase, FAT family^[9].
Protein kinase, DNA-activated, catalytic subunit is part of NUC194 domain, protein family^[10].
Protein kinase, DNA-activated, catalytic subunit is part of PIK-related kinase family^[11].
Protein kinase, DNA-activated, catalytic subunit is part of FATC domain, protein family^[12].
Protein kinase, DNA-activated, catalytic subunit is part of Phosphatidylinositol 3/4-kinase, conserved site, protein family^[13].
Protein kinase, DNA-activated, catalytic subunit comprises PIK-related kinase^[14].
Protein kinase, DNA-activated, catalytic subunit comprises FATC domain^[15].
Protein kinase, DNA-activated, catalytic subunit comprises PIK-related kinase, FAT^[16].
Protein kinase, DNA-activated, catalytic subunit comprises NUC194^[17].
Protein kinase, DNA-activated, catalytic subunit comprises Phosphatidylinositol 3/4-kinase, conserved site^[18].
Protein kinase, DNA-activated, catalytic subunit comprises Phosphatidylinositol 3-/4-kinase, catalytic domain^[19].
Protein kinase, DNA-activated, catalytic subunit comprises DNA-dependent protein kinase catalytic subunit, catalytic domain^[20].
Protein kinase, DNA-activated, catalytic subunit's molecular function is recorded as transferase activity^[21].
Protein kinase, DNA-activated, catalytic subunit's molecular function is recorded as nucleotide binding^[22].
Protein kinase, DNA-activated, catalytic subunit's molecular function is recorded as DNA binding^[23].
Protein kinase, DNA-activated, catalytic subunit's molecular function is recorded as DNA-dependent protein kinase activity^[24].
Protein kinase, DNA-activated, catalytic subunit's molecular function is recorded as transcription factor binding^[25].
Protein kinase, DNA-activated, catalytic subunit's molecular function is recorded as kinase activity^[26].
Protein kinase, DNA-activated, catalytic subunit's molecular function is recorded as protein serine/threonine kinase activity^[27].

Why It Matters

Protein kinase, DNA-activated, catalytic subunit is known by 8 alternative names across languages and contexts.^[2]

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Quick Facts

Instance of protein

Part of Protein kinase-like domain superfamily, Armadillo-type fold, Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily, Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family, DNA-dependent protein kinase catalytic subunit, catalytic domain, protein family, PIK-related kinase, FAT family, NUC194 domain, protein family, PIK-related kinase family, FATC domain, protein family, Phosphatidylinositol 3/4-kinase, conserved site, protein family

Properties

Biological process somitogenesis, negative regulation of protein phosphorylation, response to ionizing radiation, negative regulation of response to gamma radiation, positive regulation of immune system process, DNA recombination, positive regulation of developmental growth, T cell differentiation in thymus, telomere capping, phosphorylation, rhythmic process, thymus development, positive regulation of fibroblast proliferation, lymphocyte differentiation, T cell receptor V(D)J recombination, negative regulation of apoptotic process, double-strand break repair via alternative nonhomologous end joining, spleen development, negative regulation of immunoglobulin production, response to activity, regulation of smooth muscle cell proliferation, cellular response to DNA damage stimulus, development of the heart, pro-B cell differentiation, brain development, B cell lineage commitment, peptidyl-serine phosphorylation, protein destabilization, regulation of circadian rhythm, intrinsic apoptotic signaling pathway in response to DNA damage, V(D)J recombination, cellular response to insulin stimulus, positive regulation of apoptotic process, ectopic germ cell programmed cell death, immunoglobulin V(D)J recombination, cell population proliferation, double-strand break repair via nonhomologous end joining, telomere maintenance, response to gamma radiation, positive regulation of type I interferon production, T cell lineage commitment, positive regulation of transcription by RNA polymerase II, negative regulation of cellular senescence, immunoglobulin production, double-strand break repair, DNA repair, protein ubiquitination, protein phosphorylation, activation of innate immune response, immune system process, innate immune response, telomere maintenance, double-strand break repair, cellular response to DNA damage stimulus, intrinsic apoptotic signaling pathway in response to DNA damage, immunoglobulin V(D)J recombination, regulation of epithelial cell proliferation, protein phosphorylation, cellular response to DNA damage stimulus, positive regulation of double-strand break repair via nonhomologous end joining

Cell component cytosol, membrane, transcription regulator complex, nucleoplasm, DNA-dependent protein kinase-DNA ligase 4 complex, nonhomologous end joining complex, extracellular matrix, nucleus, protein-DNA complex, nucleolus, nucleus, membrane, protein-containing complex

Ec enzyme number 2.7.11.1

Encoded by PRKDC

Exact match purl.uniprot.org

Found in taxon Homo sapiens

Has part(s) PIK-related kinase, FATC domain, PIK-related kinase, FAT, NUC194, Phosphatidylinositol 3/4-kinase, conserved site, Phosphatidylinositol 3-/4-kinase, catalytic domain, DNA-dependent protein kinase catalytic subunit, catalytic domain

Molecular function transferase activity, nucleotide binding, DNA binding, DNA-dependent protein kinase activity, transcription factor binding, kinase activity, protein serine/threonine kinase activity, protein binding, enzyme binding, ATP binding, RNA binding, double-stranded DNA binding, protein kinase activity, protein domain specific binding, RNA binding, protein serine/threonine kinase activity

External References (3)

Ensembl protein id ENSP00000313420, ENSP00000345182, ENSP00000441157, ENSP00000442177

Refseq protein id NP_001075109, NP_008835

Uniprot protein id P78527

🏷️ Also known as

en DNA-dependent protein kinase catalytic subunit en DNA-PK catalytic subunit en DNPK1 en hyper-radiosensitivity of murine scid mutation, complementing 1 en p460 en PRKDC en protein kinase, DNA-activated, catalytic polypeptide en Protein kinase, DNA-activated, catalytic subunit

References

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APA

4ort.xyz Knowledge Graph. (2026). Protein kinase, DNA-activated, catalytic subunit. Retrieved May 3, 2026, from https://4ort.xyz/entity/protein-kinase-dna-activated-catalytic-subunit

MLA

“Protein kinase, DNA-activated, catalytic subunit.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/protein-kinase-dna-activated-catalytic-subunit.

BibTeX

@misc{4ortxyz_protein-kinase-dna-activated-catalytic-subunit_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Protein kinase, DNA-activated, catalytic subunit}}, year = {2026}, url = {https://4ort.xyz/entity/protein-kinase-dna-activated-catalytic-subunit}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Protein kinase, DNA-activated, catalytic subunit — https://4ort.xyz/entity/protein-kinase-dna-activated-catalytic-subunit (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/protein-kinase-dna-activated-catalytic-subunit · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

12w ago · Boghog · 2026-07-24 view diff on Wikidata ↗

Imported from → —

Encoded by → PRKDC

Wikidata description → mammalian protein found in Homo sapiens

Molecular function → transferase activity, nucleotide binding, DNA binding +13

+ 11 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ Ec enzyme number: 2.7.11.1, [[:toollabs:quickstatements/#/batch/261489|batch #261489]]"

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