Protein kinase C, alpha

mammalian protein found in Mus musculus

Protein protein Q14912658

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Protein kinase C, alpha

Summary

Protein kinase C, alpha is a protein^[1].

Key Facts

Protein kinase C, alpha's instance of is recorded as protein^[2].
Protein kinase C, alpha's UniProt protein ID is recorded as P20444^[3].
Protein kinase C, alpha's part of is recorded as C2 domain superfamily^[4].
Protein kinase C, alpha's part of is recorded as Protein kinase-like domain superfamily^[5].
Protein kinase C, alpha's part of is recorded as protein kinase C, alpha/beta/gamma types^[6].
Protein kinase C, alpha's part of is recorded as membrane protein^[7].
Protein kinase C, alpha's part of is recorded as Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family^[8].
Protein kinase C, alpha's part of is recorded as Protein kinase, C-terminal domain, protein family^[9].
Protein kinase C, alpha's part of is recorded as C2 domain, protein family^[10].
Protein kinase C, alpha's part of is recorded as Diacylglycerol/phorbol-ester binding domain, protein family^[11].
Protein kinase C, alpha's part of is recorded as AGC-kinase, C-terminal domain, protein family^[12].
Protein kinase C, alpha's part of is recorded as Classical Protein Kinase C alpha, catalytic domain, protein family^[13].
Protein kinase C, alpha's part of is recorded as Protein kinase domain, protein family^[14].
Protein kinase C, alpha's part of is recorded as Protein kinase, ATP binding site, protein family^[15].
Protein kinase C, alpha's part of is recorded as Serine/threonine-protein kinase, active site, protein family^[16].
Protein kinase C, alpha's has part is recorded as diacylglycerol/phorbol-ester binding^[17].
Protein kinase C, alpha's has part is recorded as AGC-kinase, C-terminal^[18].
Protein kinase C, alpha's has part is recorded as serine/threonine-protein kinase, active site^[19].
Protein kinase C, alpha's has part is recorded as protein kinase, C-terminal^[20].
Protein kinase C, alpha's has part is recorded as protein kinase, ATP binding site^[21].
Protein kinase C, alpha's has part is recorded as C2 domain^[22].
Protein kinase C, alpha's has part is recorded as protein kinase C-like, phorbol ester/diacylglycerol-binding domain^[23].
Protein kinase C, alpha's has part is recorded as protein kinase domain^[24].
Protein kinase C, alpha's has part is recorded as Classical Protein Kinase C alpha, catalytic domain^[25].
Protein kinase C, alpha's RefSeq protein ID is recorded as NP_035231^[26].

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Quick Facts

Instance of protein

Part of C2 domain superfamily, Protein kinase-like domain superfamily, protein kinase C, alpha/beta/gamma types, membrane protein, Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family, Protein kinase, C-terminal domain, protein family, C2 domain, protein family, Diacylglycerol/phorbol-ester binding domain, protein family, AGC-kinase, C-terminal domain, protein family, Classical Protein Kinase C alpha, catalytic domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Serine/threonine-protein kinase, active site, protein family

Properties

Biological process positive regulation of protein phosphorylation, response to interleukin-1, intrinsic apoptotic signaling pathway, protein phosphorylation, negative regulation of insulin receptor signaling pathway, angiogenesis, positive regulation of blood vessel endothelial cell migration, positive regulation of dense core granule biogenesis, regulation of platelet aggregation, negative regulation of cell population proliferation, apoptotic process, peptidyl-serine autophosphorylation, positive regulation of macrophage differentiation, positive regulation of mitotic cell cycle, neutrophil chemotaxis, negative regulation of protein phosphorylation, positive regulation of inflammatory response, chondrocyte differentiation, negative regulation of protein kinase activity, phosphorylation, regulation of the force of heart contraction, cellular calcium ion homeostasis, positive regulation of angiogenesis, positive regulation of lipopolysaccharide-mediated signaling pathway, negative regulation of glucose import, cell adhesion, regulation of peptidyl-tyrosine phosphorylation, cellular response to carbohydrate stimulus, regulation of muscle contraction, positive regulation of endothelial cell proliferation, positive regulation of cell migration, negative regulation of glial cell apoptotic process, positive regulation of endothelial cell migration, induction of positive chemotaxis, desmosome assembly, positive regulation of cell adhesion, negative regulation of anion channel activity, regulation of response to osmotic stress, positive regulation of bone resorption, response to reactive oxygen species, learning or memory, positive regulation of cardiac muscle hypertrophy, negative regulation of translation, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, central nervous system neuron axonogenesis, response to estradiol, intracellular signal transduction, response to ethanol, negative regulation of heart contraction, positive regulation of exocytosis, protein autophosphorylation, regulation of receptor-mediated endocytosis, positive regulation of smooth muscle cell proliferation, positive regulation of synapse assembly, positive regulation of ERK1 and ERK2 cascade, peptidyl-serine phosphorylation, intracellular signal transduction, presynaptic modulation of chemical synaptic transmission, regulation of synaptic vesicle exocytosis

Cell component cytoplasm, membrane, photoreceptor outer segment, nucleus, mitochondrial membranes, endoplasmic reticulum, plasma membrane, apical part of cell, axon, soma, dendrite, cytosol, alphav-beta3 integrin-PKCalpha complex, mitochondrion, protein-containing complex, neuron projection, membrane raft, perinuclear region of cytoplasm, calyx of Held, presynaptic cytosol, intercalated disc, protein-containing complex

Encoded by Prkca

Found in taxon house mouse

Has part(s) diacylglycerol/phorbol-ester binding, AGC-kinase, C-terminal, serine/threonine-protein kinase, active site, protein kinase, C-terminal, protein kinase, ATP binding site, C2 domain, protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein kinase domain, Classical Protein Kinase C alpha, catalytic domain

Imported from wholeness_audit_2026-05-02

Molecular function kinase activity, ATP binding, protein kinase activity, metal ion binding, protein serine/threonine kinase activity, enzyme binding, histone kinase activity (H3-T6 specific), transferase activity, zinc ion binding, protein binding, nucleotide binding, integrin binding, protein kinase C activity, calcium-dependent protein kinase C activity, protein serine/threonine kinase activity

External References (4)

Ensembl protein id ENSMUSP00000062392, ENSMUSP00000097875

Refseq protein id NP_035231, XP_036012317

Umls cui C0256371

Uniprot protein id P20444

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Protein kinase C, alpha — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Protein kinase C, alpha — UniProt protein ID (P352): P20444. Q905695. Retrieved 2022-05-25. wikidata.org.
[4] ↑ Protein kinase C, alpha — part of (P361): C2 domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Protein kinase C, alpha — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Protein kinase C, alpha — part of (P361): protein kinase C, alpha/beta/gamma types. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Protein kinase C, alpha — part of (P361): membrane protein. wikidata.org.
[8] ↑ Protein kinase C, alpha — part of (P361): Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family. wikidata.org.
[9] ↑ Protein kinase C, alpha — part of (P361): Protein kinase, C-terminal domain, protein family. wikidata.org.
[10] ↑ Protein kinase C, alpha — part of (P361): C2 domain, protein family. wikidata.org.
[11] ↑ Protein kinase C, alpha — part of (P361): Diacylglycerol/phorbol-ester binding domain, protein family. wikidata.org.
[12] ↑ Protein kinase C, alpha — part of (P361): AGC-kinase, C-terminal domain, protein family. wikidata.org.
[13] ↑ Protein kinase C, alpha — part of (P361): Classical Protein Kinase C alpha, catalytic domain, protein family. wikidata.org.
[14] ↑ Protein kinase C, alpha — part of (P361): Protein kinase domain, protein family. wikidata.org.
[15] ↑ Protein kinase C, alpha — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[16] ↑ Protein kinase C, alpha — part of (P361): Serine/threonine-protein kinase, active site, protein family. wikidata.org.
[17] ↑ Protein kinase C, alpha — has part(s) (P527): diacylglycerol/phorbol-ester binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Protein kinase C, alpha — has part(s) (P527): AGC-kinase, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Protein kinase C, alpha — has part(s) (P527): serine/threonine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Protein kinase C, alpha — has part(s) (P527): protein kinase, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Protein kinase C, alpha — has part(s) (P527): protein kinase, ATP binding site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Protein kinase C, alpha — has part(s) (P527): C2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Protein kinase C, alpha — has part(s) (P527): protein kinase C-like, phorbol ester/diacylglycerol-binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Protein kinase C, alpha — has part(s) (P527): protein kinase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Protein kinase C, alpha — has part(s) (P527): Classical Protein Kinase C alpha, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Protein kinase C, alpha — RefSeq protein ID (P637): NP_035231. Q20641742. Retrieved 2022-03-20. wikidata.org.

Class ancestry

[1] ↑ Protein kinase C, alpha is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Protein kinase C, alpha. Retrieved May 3, 2026, from https://4ort.xyz/entity/protein-kinase-c-alpha-q14912658

MLA

“Protein kinase C, alpha.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/protein-kinase-c-alpha-q14912658.

BibTeX

@misc{4ortxyz_protein-kinase-c-alpha-q14912658_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Protein kinase C, alpha}}, year = {2026}, url = {https://4ort.xyz/entity/protein-kinase-c-alpha-q14912658}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Protein kinase C, alpha — https://4ort.xyz/entity/protein-kinase-c-alpha-q14912658 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/protein-kinase-c-alpha-q14912658 · Last refreshed: May 3, 2026