Proliferating cell nuclear antigen
mammalian protein found in Homo sapiens
Facts
9 properties- Instance of
- protein
- Part of
- proliferating cell nuclear antigen, Proliferating cell nuclear antigen, PCNA, C-terminal domain, protein family, Proliferating cell nuclear antigen, PCNA, N-terminal domain, protein family, Proliferating cell nuclear antigen, PCNA, conserved site, protein family[2][3][4][5]
- Biological process
- replication fork processing, translesion synthesis, DNA replication, nucleotide-excision repair, DNA gap filling, protein sumoylation, regulation of DNA replication, transcription-coupled nucleotide-excision repair, positive regulation of deoxyribonuclease activity, nucleotide-excision repair, DNA incision, error-free translesion synthesis, positive regulation of DNA repair, regulation of transcription involved in G1/S transition of mitotic cell cycle, positive regulation of DNA replication, response to lipid, development of the heart, DNA mismatch repair, cellular response to DNA damage stimulus, mitotic telomere maintenance via semi-conservative replication, epithelial cell differentiation, response to cadmium ion, cell population proliferation, telomere maintenance, error-prone translesion synthesis, cellular response to UV, estrous cycle, cellular response to hydrogen peroxide, response to dexamethasone, nucleotide-excision repair, DNA incision, 5'-to lesion, liver regeneration, response to estradiol, response to oxidative stress, DNA repair, response to L-glutamate, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, DNA ligation, leading strand elongation, protein ubiquitination, telomere maintenance via semi-conservative replication, DNA mismatch repair, viral process, translesion synthesis
- Cell component
- nucleus, replisome, nucleoplasm, extracellular exosome, DNA replication factor C complex, centrosome, PCNA complex, nuclear replication fork, PCNA-p21 complex, replication fork, nuclear body, chromatin, nucleus, PCNA complex, extracellular exosome
- Encoded by
- PCNA
- Found in taxon
- Homo sapiens
- Has part(s)
- Proliferating cell nuclear antigen, PCNA, C-terminal, Proliferating cell nuclear antigen, PCNA, conserved site, Proliferating cell nuclear antigen, PCNA, N-terminal[6][7][8]
- Has parts
- Proliferating cell nuclear antigen, PCNA, C-terminal, Proliferating cell nuclear antigen, PCNA, conserved site, Proliferating cell nuclear antigen, PCNA, N-terminal
- Molecular function
- MutLalpha complex binding, identical protein binding, enzyme binding, receptor tyrosine kinase binding, DNA binding, DNA polymerase binding, damaged DNA binding, dinucleotide insertion or deletion binding, protein binding, chromatin binding, histone acetyltransferase binding, estrogen receptor binding, purine-specific mismatch base pair DNA N-glycosylase activity, DNA polymerase processivity factor activity
🏷️ Also known as
en Proliferating cell nuclear antigen
en cyclin
en DNA polymerase delta auxiliary protein
en PCNA
en proliferating cell nuclear antigen
de Proliferating cell nuclear antigen
de Proliferating-Cell-Nuclear-Antigen
de Ringklemmenprotein
de PCNA
fi PCNA
fi Proliferoivan solun tuma-antigeeni
fr Proliferating Cell Nuclear Antigen
hu proliferálósejt-magantigén
ja 増殖細胞核抗原
nl PCNA
pt Antígeno nuclear de célula proliferante
uk Ядерний антиген проліферуючих клітин
zh 增殖細胞核抗原
🔖 Identifiers · 10
- OpenAlex ID
- C34688535
- Ensembl protein ID
- ENSP00000368458, ENSP00000368438
- Exact match
- purl.uniprot.org
- Freebase ID
- /m/0dtmfw
- HGNC ID
- 8729
- Microsoft Academic ID (discontinued)
- 34688535
- PDB structure ID
- 4D2G, 1AXC, 1U76, 1U7B, 1UL1, 1VYJ, 1VYM, 1W60, 2ZVK, 2ZVL, 2ZVM, 3P87, 3TBL, 3VKX, 3WGW, 4RJF, 3JA9, 4ZTD, 5IY4, 5E0U, 5E0T, 5E0V
- UMLS CUI
- C0072108
- UniProt protein ID
- P12004
🔗 Connections
Cell component 11
Biological process 8
Found in taxon 1
Instance of 1
Molecular function 1
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Summary
Proliferating cell nuclear antigen is a protein[1].