Prion protein

mammalian protein found in Mus musculus

Protein protein Q14881308

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Prion protein

Summary

Prion protein is a protein^[1].

Key Facts

Prion protein's instance of is recorded as protein^[2].
Prion protein's UniProt protein ID is recorded as P04925^[3].
Prion protein's part of is recorded as prion protein family^[4].
Prion protein's part of is recorded as Prion/Doppel beta-ribbon domain superfamily^[5].
Prion protein's part of is recorded as membrane protein^[6].
Prion protein's part of is recorded as Prion/Doppel protein, beta-ribbon domain, protein family^[7].
Prion protein's part of is recorded as Major prion protein N-terminal domain, protein family^[8].
Prion protein's has part is recorded as Major prion protein N-terminal domain^[9].
Prion protein's has part is recorded as Prion/Doppel protein, beta-ribbon domain^[10].
Prion protein's RefSeq protein ID is recorded as NP_001265185^[11].
Prion protein's RefSeq protein ID is recorded as NP_035300^[12].
Prion protein's PDB structure ID is recorded as 1AG2^[13].
Prion protein's PDB structure ID is recorded as 1XYX^[14].
Prion protein's PDB structure ID is recorded as 1Y15^[15].
Prion protein's PDB structure ID is recorded as 1Y16^[16].
Prion protein's PDB structure ID is recorded as 2K5O^[17].
Prion protein's PDB structure ID is recorded as 2KFM^[18].
Prion protein's PDB structure ID is recorded as 2KFO^[19].
Prion protein's PDB structure ID is recorded as 2KU5^[20].
Prion protein's PDB structure ID is recorded as 2KU6^[21].
Prion protein's PDB structure ID is recorded as 2L1D^[22].
Prion protein's PDB structure ID is recorded as 2L1E^[23].
Prion protein's PDB structure ID is recorded as 2L1H^[24].
Prion protein's PDB structure ID is recorded as 2L1K^[25].
Prion protein's PDB structure ID is recorded as 2L39^[26].

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Quick Facts

Instance of protein

Part of prion protein family, Prion/Doppel beta-ribbon domain superfamily, membrane protein, Prion/Doppel protein, beta-ribbon domain, protein family, Major prion protein N-terminal domain, protein family

Properties

Biological process negative regulation of protein phosphorylation, negative regulation of interferon-gamma production, negative regulation of calcineurin-NFAT signaling cascade, response to oxidative stress, negative regulation of DNA-binding transcription factor activity, negative regulation of T cell receptor signaling pathway, regulation of protein localization, negative regulation of activated T cell proliferation, cellular copper ion homeostasis, cellular response to copper ion, negative regulation of interleukin-17 production, protein homooligomerization, nucleobase-containing compound metabolic process, negative regulation of interleukin-2 production, regulation of potassium ion transmembrane transport, response to copper ion, negative regulation of apoptotic process, response to cadmium ion, learning or memory, response to oxidative stress, learning or memory, positive regulation of cell death, protein destabilization, activation of protein kinase activity, calcium-mediated signaling using intracellular calcium source, amyloid precursor protein metabolic process, negative regulation of apoptotic process, negative regulation of catalytic activity, positive regulation of neuron apoptotic process, response to cadmium ion, response to copper ion, regulation of peptidyl-tyrosine phosphorylation, positive regulation of peptidyl-tyrosine phosphorylation, protein homooligomerization, positive regulation of protein tyrosine kinase activity, positive regulation of protein targeting to membrane, negative regulation of long-term synaptic potentiation, regulation of glutamate receptor signaling pathway, positive regulation of neuron death, negative regulation of amyloid-beta formation, regulation of intracellular calcium activated chloride channel activity, negative regulation of dendritic spine maintenance, negative regulation of amyloid precursor protein catabolic process, positive regulation of protein localization to plasma membrane, response to amyloid-beta, cellular response to amyloid-beta, regulation of calcium ion import across plasma membrane, neuron projection maintenance

Cell component Golgi apparatus, plasma membrane, cell surface, endoplasmic reticulum, membrane raft, anchored component of membrane, extracellular exosome, membrane, cytoplasm, cytoplasm, mitochondrial outer membrane, cytosol, plasma membrane, postsynaptic density, membrane, inclusion body, dendrite, nuclear membrane, intracellular membrane-bounded organelle, membrane raft

Encoded by Prnp

Found in taxon house mouse

Has part(s) Major prion protein N-terminal domain, Prion/Doppel protein, beta-ribbon domain

Imported from wholeness_audit_2026-05-02

Molecular function microtubule binding, metal ion binding, tubulin binding, protein binding, identical protein binding, copper ion binding, chaperone binding, transmembrane transporter binding, lamin binding, ATP-dependent protein binding, amyloid-beta binding, protease binding, protein binding, lamin binding, glycosaminoglycan binding, microtubule binding, type 5 metabotropic glutamate receptor binding, signaling receptor activity, identical protein binding, ATP-dependent protein binding, transmembrane transporter binding, protein-containing complex binding, chaperone binding, cupric ion binding, cuprous ion binding

External References (4)

Ensembl protein id ENSMUSP00000088833

Pdb structure id 1AG2, 1XYX, 1Y15, 1Y16, 2K5O, 2KFM, 2KFO, 2KU5, 2KU6, 2L1D, 2L1E, 2L1H, 2L1K, 2L39, 2L40, 4H88, 4J8R, 3NVG, 3NVH, 4MA7, 4MA8

Refseq protein id NP_001265185, NP_035300

Uniprot protein id P04925

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Prion protein — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Prion protein — UniProt protein ID (P352): P04925. Q905695. Retrieved 2022-05-25. wikidata.org.
[4] ↑ Prion protein — part of (P361): prion protein family. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Prion protein — part of (P361): Prion/Doppel beta-ribbon domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Prion protein — part of (P361): membrane protein. wikidata.org.
[7] ↑ Prion protein — part of (P361): Prion/Doppel protein, beta-ribbon domain, protein family. wikidata.org.
[8] ↑ Prion protein — part of (P361): Major prion protein N-terminal domain, protein family. wikidata.org.
[9] ↑ Prion protein — has part(s) (P527): Major prion protein N-terminal domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Prion protein — has part(s) (P527): Prion/Doppel protein, beta-ribbon domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Prion protein — RefSeq protein ID (P637): NP_001265185. Q20641742. Retrieved 2022-03-20. wikidata.org.
[12] ↑ Prion protein — RefSeq protein ID (P637): NP_035300. Q20641742. Retrieved 2022-03-20. wikidata.org.
[13] ↑ Prion protein — PDB structure ID (P638): 1AG2. Q905695. Retrieved 2016-08-10. wikidata.org.
[14] ↑ Prion protein — PDB structure ID (P638): 1XYX. Q905695. Retrieved 2016-08-10. wikidata.org.
[15] ↑ Prion protein — PDB structure ID (P638): 1Y15. Q905695. Retrieved 2016-08-10. wikidata.org.
[16] ↑ Prion protein — PDB structure ID (P638): 1Y16. Q905695. Retrieved 2016-08-10. wikidata.org.
[17] ↑ Prion protein — PDB structure ID (P638): 2K5O. Q905695. Retrieved 2016-08-10. wikidata.org.
[18] ↑ Prion protein — PDB structure ID (P638): 2KFM. Q905695. Retrieved 2016-08-10. wikidata.org.
[19] ↑ Prion protein — PDB structure ID (P638): 2KFO. Q905695. Retrieved 2016-08-10. wikidata.org.
[20] ↑ Prion protein — PDB structure ID (P638): 2KU5. Q905695. Retrieved 2016-08-10. wikidata.org.
[21] ↑ Prion protein — PDB structure ID (P638): 2KU6. Q905695. Retrieved 2016-08-10. wikidata.org.
[22] ↑ Prion protein — PDB structure ID (P638): 2L1D. Q905695. Retrieved 2016-08-10. wikidata.org.
[23] ↑ Prion protein — PDB structure ID (P638): 2L1E. Q905695. Retrieved 2016-08-10. wikidata.org.
[24] ↑ Prion protein — PDB structure ID (P638): 2L1H. Q905695. Retrieved 2016-08-10. wikidata.org.
[25] ↑ Prion protein — PDB structure ID (P638): 2L1K. Q905695. Retrieved 2016-08-10. wikidata.org.
[26] ↑ Prion protein — PDB structure ID (P638): 2L39. Q905695. Retrieved 2016-08-10. wikidata.org.

Class ancestry

[1] ↑ Prion protein is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Prion protein. Retrieved May 3, 2026, from https://4ort.xyz/entity/prion-protein-q14881308

MLA “Prion protein.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/prion-protein-q14881308.

BibTeX

@misc{4ortxyz_prion-protein-q14881308_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Prion protein}}, year = {2026}, url = {https://4ort.xyz/entity/prion-protein-q14881308}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Prion protein — https://4ort.xyz/entity/prion-protein-q14881308 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/prion-protein-q14881308 · Last refreshed: May 3, 2026