preproinsulin

mammalian protein found in Homo sapiens

ChemicalSubstance protein_precursor Q7240673

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preproinsulin

Summary

preproinsulin is a protein precursor^[1].

Key Facts

preproinsulin's instance of is recorded as protein precursor^[2].
preproinsulin's instance of is recorded as protein^[3].
preproinsulin's UniProt protein ID is recorded as P01308^[4].
preproinsulin's part of is recorded as Insulin/IGF/Relaxin family^[5].
preproinsulin's part of is recorded as Insulin-like superfamily^[6].
preproinsulin's part of is recorded as Insulin-like domain, protein family^[7].
preproinsulin's part of is recorded as Insulin, conserved site, protein family^[8].
preproinsulin's has part is recorded as proinsulin^[9].
preproinsulin's has part is recorded as Insulin-like^[10].
preproinsulin's has part is recorded as Insulin, conserved site^[11].
preproinsulin's RefSeq protein ID is recorded as NP_000198^[12].
preproinsulin's RefSeq protein ID is recorded as NP_001172026^[13].
preproinsulin's RefSeq protein ID is recorded as NP_001172027^[14].
preproinsulin's RefSeq protein ID is recorded as NP_001278826^[15].
preproinsulin's PDB structure ID is recorded as 1A7F^[16].
preproinsulin's PDB structure ID is recorded as 1AI0^[17].
preproinsulin's PDB structure ID is recorded as 1AIY^[18].
preproinsulin's PDB structure ID is recorded as 1B9E^[19].
preproinsulin's PDB structure ID is recorded as 1BEN^[20].
preproinsulin's PDB structure ID is recorded as 1EV3^[21].
preproinsulin's PDB structure ID is recorded as 1EV6^[22].
preproinsulin's PDB structure ID is recorded as 1EVR^[23].
preproinsulin's PDB structure ID is recorded as 1FU2^[24].
preproinsulin's PDB structure ID is recorded as 1FUB^[25].
preproinsulin's PDB structure ID is recorded as 1G7A^[26].

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Quick Facts

Instance of protein precursor, protein

Part of Insulin/IGF/Relaxin family, Insulin-like superfamily, Insulin-like domain, protein family, Insulin, conserved site, protein family

Properties

Biological process negative regulation of NAD(P)H oxidase activity, positive regulation of DNA replication, positive regulation of MAPK cascade, positive regulation of brown fat cell differentiation, positive regulation of cell differentiation, MAPK cascade, positive regulation of respiratory burst, positive regulation of phosphatidylinositol 3-kinase signaling, negative regulation of protein oligomerization, positive regulation of NF-kappaB transcription factor activity, negative regulation of respiratory burst involved in inflammatory response, cell-cell signaling, positive regulation of nitric oxide biosynthetic process, positive regulation of glycolytic process, positive regulation of nitric-oxide synthase activity, positive regulation of protein autophosphorylation, activation of protein kinase B activity, wound healing, positive regulation of mitotic nuclear division, negative regulation of feeding behavior, positive regulation of peptide hormone secretion, negative regulation of protein catabolic process, positive regulation of cell migration, acute-phase response, regulation of protein secretion, positive regulation of glycogen biosynthetic process, positive regulation of protein kinase B signaling, G protein-coupled receptor signaling pathway, regulation of cellular amino acid metabolic process, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, endoplasmic reticulum to Golgi vesicle-mediated transport, negative regulation of lipid catabolic process, positive regulation of cell growth, negative regulation of glycogen catabolic process, positive regulation of insulin receptor signaling pathway, glucose metabolic process, negative regulation of acute inflammatory response, negative regulation of protein secretion, positive regulation of peptidyl-tyrosine phosphorylation, glucose homeostasis, positive regulation of cell population proliferation, fatty acid homeostasis, positive regulation of protein metabolic process, regulation of transmembrane transporter activity, negative regulation of gluconeogenesis, negative regulation of fatty acid metabolic process, regulation of protein localization, regulation of transcription, DNA-templated, positive regulation of lipid biosynthetic process, carbohydrate metabolic process, negative regulation of proteolysis, alpha-beta T cell activation, positive regulation of protein localization to nucleus, positive regulation of glucose import, insulin receptor signaling pathway, positive regulation of gene expression, regulation of signaling receptor activity, positive regulation of nitric oxide mediated signal transduction, positive regulation of glucose import, positive regulation of insulin receptor signaling pathway, regulation of synaptic plasticity, cognition, positive regulation of long-term synaptic potentiation, positive regulation of dendritic spine maintenance, regulation of protein localization to plasma membrane, negative regulation of reactive oxygen species biosynthetic process, neuron projection maintenance, response to L-arginine, signal transduction

Cell component endoplasmic reticulum lumen, transport vesicle, Golgi membrane, secretory granule lumen, Golgi lumen, endoplasmic reticulum-Golgi intermediate compartment membrane, endosome lumen, extracellular region, extracellular space, extracellular region, extracellular space

Different from INS

Encoded by INS

Found in taxon Homo sapiens

Has part(s) proinsulin, Insulin-like, Insulin, conserved site

Imported from wholeness_audit_2026-05-02

Mcn code 2937.12.00

Molecular function insulin receptor binding, identical protein binding, protease binding, insulin-like growth factor receptor binding, protein binding, hormone activity, insulin-like growth factor receptor binding, hormone activity

External References (7)

Brockhaus enzyklopädie online id humaninsulin

Ensembl protein id ENSP00000250971, ENSP00000370731, ENSP00000380432, ENSP00000408400, ENSP00000424008

Freebase id /m/03cnxnh

Pdb structure id 1A7F, 1AI0, 1AIY, 1B9E, 1BEN, 1EV3, 1EV6, 1EVR, 1FU2, 1FUB, 1G7A, 1G7B, 1GUJ, 1HIQ, 1HIS, 1HIT, 1HLS, 1HTV, 1HUI, 1IOG, 1IOH, 1J73, 1JCA, 1JCO, 1K3M, 1KMF, 1LKQ, 1LPH, 1MHI, 1MHJ, 1MSO, 1OS3, 1OS4, 1Q4V, 1QIY, 1QIZ, 1QJ0, 1RWE, 1SF1, 1T1K, 1T1P, 1T1Q, 1TRZ, 1TYL, 1TYM, 1UZ9, 1VKT, 1W8P, 1XDA, 1XGL, 1XW7, 1ZEG, 1ZEH, 1ZNJ, 2AIY, 2C8Q, 2C8R, 2CEU, 2H67, 2HH4, 2HHO, 2HIU, 2JMN, 2JUM, 2JUU, 2JUV, 2JV1, 2JZQ, 2K91, 2K9R, 2KJJ, 2KJU, 2KQQ, 2KXK, 2L1Y, 2L1Z, 2LGB, 2M1D, 2M1E, 2M2M, 2M2N, 2M2O, 2M2P, 2OLY, 2OLZ, 2OM0, 2OM1, 2OMG, 2OMH, 2OMI, 2QIU, 2R34, 2R35, 2R36, 2RN5, 2VJZ, 2VK0, 2W44, 2WBY, 2WC0, 2WRU, 2WRV, 2WRW, 2WRX, 2WS0, 2WS1, 2WS4, 2WS6, 2WS7, 3AIY, 3BXQ, 3E7Y, 3E7Z, 3EXX, 3FQ9, 3I3Z, 3I40, 3ILG, 3INC, 3IR0, 3Q6E, 3ROV, 3TT8, 3U4N, 3UTQ, 3UTS, 3UTT, 3V19, 3V1G, 3W11, 3W12, 3W13, 3W7Y, 3W7Z, 3W80, 3ZI3, 3ZQR, 3ZS2, 3ZU1, 4AIY, 4AJX, 4AJZ, 4AK0, 4AKJ, 4EFX, 4EWW, 4EWX, 4EWZ, 4EX0, 4EX1, 4EXX, 4EY1, 4EY9, 4EYD, 4EYN, 4EYP, 4F0N, 4F0O, 4F1A, 4F1B, 4F1C, 4F1D, 4F1F, 4F1G, 4F4T, 4F4V, 4F51, 4F8F, 4FG3, 4FKA, 4GBC, 4GBI, 4GBK, 4GBL, 4GBN, 4IUZ, 5AIY, 2LWZ, 3JSD, 3KQ6, 3P2X, 3P33, 1JK8, 2MLI, 2MPG, 2MPI, 2MVC, 2MVD, 4CXL, 4CXN, 4CY7, 4NIB, 4OGA, 4P65, 4Q5Z, 4RXW, 4UNE, 4UNG, 4UNH, 4XC4, 4WDI, 4Z76, 4Z77, 4Z78, 2N2W, 5CO6, 5ENA, 4Y19, 5BQQ, 5BOQ, 2N2V, 5CNY, 5CO9, 5EN9, 4Y1A, 2N2X, 5BPO, 5CO2, 5BTS, 5HYJ, 5C0D

Quora topic id Insulin

Refseq protein id NP_000198, NP_001172026, NP_001172027, NP_001278826

Uniprot protein id P01308

🌐 Available in 3 languages

frPréproinsuline itPreproinsulina mkПрепроинсулин

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ preproinsulin — instance of (P31): protein precursor. wikidata.org.
[3] ↑ preproinsulin — instance of (P31): protein. Q905695. Retrieved 2019-12-18. wikidata.org.
[4] ↑ preproinsulin — UniProt protein ID (P352): P01308. Q905695. Retrieved 2019-12-18. wikidata.org.
[5] ↑ preproinsulin — part of (P361): Insulin/IGF/Relaxin family. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ preproinsulin — part of (P361): Insulin-like superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ preproinsulin — part of (P361): Insulin-like domain, protein family. wikidata.org.
[8] ↑ preproinsulin — part of (P361): Insulin, conserved site, protein family. wikidata.org.
[9] ↑ preproinsulin — has part(s) (P527): proinsulin. wikidata.org.
[10] ↑ preproinsulin — has part(s) (P527): Insulin-like. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ preproinsulin — has part(s) (P527): Insulin, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ preproinsulin — RefSeq protein ID (P637): NP_000198. Q20641742. Retrieved 2019-12-27. wikidata.org.
[13] ↑ preproinsulin — RefSeq protein ID (P637): NP_001172026. Q20641742. Retrieved 2019-12-27. wikidata.org.
[14] ↑ preproinsulin — RefSeq protein ID (P637): NP_001172027. Q20641742. Retrieved 2019-12-27. wikidata.org.
[15] ↑ preproinsulin — RefSeq protein ID (P637): NP_001278826. Q20641742. Retrieved 2019-12-27. wikidata.org.
[16] ↑ preproinsulin — PDB structure ID (P638): 1A7F. Q905695. Retrieved 2016-08-05. wikidata.org.
[17] ↑ preproinsulin — PDB structure ID (P638): 1AI0. Q905695. Retrieved 2016-08-05. wikidata.org.
[18] ↑ preproinsulin — PDB structure ID (P638): 1AIY. Q905695. Retrieved 2016-08-05. wikidata.org.
[19] ↑ preproinsulin — PDB structure ID (P638): 1B9E. Q905695. Retrieved 2016-08-05. wikidata.org.
[20] ↑ preproinsulin — PDB structure ID (P638): 1BEN. Q905695. Retrieved 2016-08-05. wikidata.org.
[21] ↑ preproinsulin — PDB structure ID (P638): 1EV3. Q905695. Retrieved 2016-08-05. wikidata.org.
[22] ↑ preproinsulin — PDB structure ID (P638): 1EV6. Q905695. Retrieved 2016-08-05. wikidata.org.
[23] ↑ preproinsulin — PDB structure ID (P638): 1EVR. Q905695. Retrieved 2016-08-05. wikidata.org.
[24] ↑ preproinsulin — PDB structure ID (P638): 1FU2. Q905695. Retrieved 2016-08-05. wikidata.org.
[25] ↑ preproinsulin — PDB structure ID (P638): 1FUB. Q905695. Retrieved 2016-08-05. wikidata.org.
[26] ↑ preproinsulin — PDB structure ID (P638): 1G7A. Q905695. Retrieved 2016-08-05. wikidata.org.

Class ancestry

[1] ↑ preproinsulin is an instance of protein precursor (Q258658) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). preproinsulin. Retrieved May 3, 2026, from https://4ort.xyz/entity/preproinsulin

MLA “preproinsulin.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/preproinsulin.

BibTeX

@misc{4ortxyz_preproinsulin_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{preproinsulin}}, year = {2026}, url = {https://4ort.xyz/entity/preproinsulin}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): preproinsulin — https://4ort.xyz/entity/preproinsulin (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/preproinsulin · Last refreshed: May 3, 2026