POU domain, class 4, transcription factor 2

mammalian protein found in Mus musculus

Protein protein Q21986679

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Summary

POU domain, class 4, transcription factor 2 is a protein^[1].

Key Facts

POU domain, class 4, transcription factor 2's instance of is recorded as protein^[2].
POU domain, class 4, transcription factor 2's UniProt protein ID is recorded as Canon EOS-1D X^[3].
POU domain, class 4, transcription factor 2's part of is recorded as Lambda repressor-like, DNA-binding domain superfamily^[4].
POU domain, class 4, transcription factor 2's part of is recorded as Homeobox-like domain superfamily^[5].
POU domain, class 4, transcription factor 2's part of is recorded as membrane protein^[6].
POU domain, class 4, transcription factor 2's part of is recorded as Homeobox domain, protein family^[7].
POU domain, class 4, transcription factor 2's part of is recorded as POU domain, protein family^[8].
POU domain, class 4, transcription factor 2's part of is recorded as POU-specific domain, protein family^[9].
POU domain, class 4, transcription factor 2's part of is recorded as Cro/C1-type helix-turn-helix domain, protein family^[10].
POU domain, class 4, transcription factor 2's part of is recorded as Homeobox, conserved site, protein family^[11].
POU domain, class 4, transcription factor 2's has part is recorded as Homeobox domain^[12].
POU domain, class 4, transcription factor 2's has part is recorded as Homeobox, conserved site^[13].
POU domain, class 4, transcription factor 2's has part is recorded as POU-specific domain^[14].
POU domain, class 4, transcription factor 2's has part is recorded as POU domain^[15].
POU domain, class 4, transcription factor 2's has part is recorded as Cro/C1-type helix-turn-helix domain^[16].
POU domain, class 4, transcription factor 2's RefSeq protein ID is recorded as NP_620394^[17].
POU domain, class 4, transcription factor 2's molecular function is recorded as DNA binding^[18].
POU domain, class 4, transcription factor 2's molecular function is recorded as DNA-binding transcription factor activity^[19].
POU domain, class 4, transcription factor 2's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[20].
POU domain, class 4, transcription factor 2's molecular function is recorded as chromatin binding^[21].
POU domain, class 4, transcription factor 2's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[22].
POU domain, class 4, transcription factor 2's molecular function is recorded as DNA-binding transcription repressor activity, RNA polymerase II-specific^[23].
POU domain, class 4, transcription factor 2's molecular function is recorded as DNA-binding transcription factor activity, RNA polymerase II-specific^[24].
POU domain, class 4, transcription factor 2's molecular function is recorded as protein binding^[25].
POU domain, class 4, transcription factor 2's molecular function is recorded as sequence-specific DNA binding^[26].

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Quick Facts

Instance of protein

Part of Lambda repressor-like, DNA-binding domain superfamily, Homeobox-like domain superfamily, membrane protein, Homeobox domain, protein family, POU domain, protein family, POU-specific domain, protein family, Cro/C1-type helix-turn-helix domain, protein family, Homeobox, conserved site, protein family

Properties

Biological process regulation of transcription, DNA-templated, axonogenesis, neuromuscular process controlling balance, hearing, transcription, DNA-templated, MAPK cascade, axon guidance, retina development in camera-type eye, positive regulation of cell differentiation, neuron differentiation, spermatogenesis, axon extension, intracellular estrogen receptor signaling pathway, retinal ganglion cell axon guidance, transcription by RNA polymerase II, negative regulation of DNA-binding transcription factor activity, positive regulation of transcription by RNA polymerase II, positive regulation of programmed cell death, negative regulation of cell differentiation, positive regulation of osteoclast differentiation, positive regulation of axon extension, regulation of DNA-binding transcription factor activity, cellular response to cytokine stimulus, cellular response to estradiol stimulus, intrinsic apoptotic signaling pathway by p53 class mediator, regulation of retinal ganglion cell axon guidance, negative regulation of amacrine cell differentiation, dorsal root ganglion development, positive regulation of transcription regulatory region DNA binding, apoptotic process, multicellular organism development, cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of nucleic acid-templated transcription, development of the heart, regulation of gene expression, positive regulation of cardiac muscle cell apoptotic process, cellular response to insulin stimulus, positive regulation of glucose import, cellular response to oxygen levels, negative regulation of adipose tissue development

Cell component intracellular anatomical structure, nuclear speck, cytoplasm, plasma membrane, membrane, nucleus, transcription regulator complex

Encoded by Pou4f2

Found in taxon house mouse

Has part(s) Homeobox domain, Homeobox, conserved site, POU-specific domain, POU domain, Cro/C1-type helix-turn-helix domain

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, DNA-binding transcription factor activity, DNA-binding transcription activator activity, RNA polymerase II-specific, chromatin binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, protein binding, sequence-specific DNA binding, transcription coactivator activity, transcription corepressor activity, promoter-specific chromatin binding, p53 binding, sequence-specific DNA binding

External References (3)

Ensembl protein id ENSMUSP00000034115

Refseq protein id NP_620394

Uniprot protein id Canon EOS-1D X

🏷️ Also known as

en brain-3B en brain-specific homeobox/POU domain protein 3B en Brn-3.2 en Brn-3B en Pou4f2 en POU domain, class 4, transcription factor 2 en POU domain, class 4, transcription factor, related sequence 1

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ POU domain, class 4, transcription factor 2 — instance of (P31): protein. UniProt. Retrieved 2022-05-25. wikidata.org.
[3] ↑ POU domain, class 4, transcription factor 2 — UniProt protein ID (P352): Canon EOS-1D X. UniProt. Retrieved 2022-05-25. wikidata.org.
[4] ↑ POU domain, class 4, transcription factor 2 — part of (P361): Lambda repressor-like, DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ POU domain, class 4, transcription factor 2 — part of (P361): Homeobox-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ POU domain, class 4, transcription factor 2 — part of (P361): membrane protein. wikidata.org.
[7] ↑ POU domain, class 4, transcription factor 2 — part of (P361): Homeobox domain, protein family. wikidata.org.
[8] ↑ POU domain, class 4, transcription factor 2 — part of (P361): POU domain, protein family. wikidata.org.
[9] ↑ POU domain, class 4, transcription factor 2 — part of (P361): POU-specific domain, protein family. wikidata.org.
[10] ↑ POU domain, class 4, transcription factor 2 — part of (P361): Cro/C1-type helix-turn-helix domain, protein family. wikidata.org.
[11] ↑ POU domain, class 4, transcription factor 2 — part of (P361): Homeobox, conserved site, protein family. wikidata.org.
[12] ↑ POU domain, class 4, transcription factor 2 — has part(s) (P527): Homeobox domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ POU domain, class 4, transcription factor 2 — has part(s) (P527): Homeobox, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ POU domain, class 4, transcription factor 2 — has part(s) (P527): POU-specific domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ POU domain, class 4, transcription factor 2 — has part(s) (P527): POU domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ POU domain, class 4, transcription factor 2 — has part(s) (P527): Cro/C1-type helix-turn-helix domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ POU domain, class 4, transcription factor 2 — RefSeq protein ID (P637): NP_620394. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ POU domain, class 4, transcription factor 2 — molecular function (P680): DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ POU domain, class 4, transcription factor 2 — molecular function (P680): DNA-binding transcription factor activity. A POU domain transcription factor-dependent program regulates axon pathfinding in the vertebrate visual system. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ POU domain, class 4, transcription factor 2 — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. GOA. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ POU domain, class 4, transcription factor 2 — molecular function (P680): chromatin binding. Early B-cell factors are required for specifying multiple retinal cell types and subtypes from postmitotic precursors. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ POU domain, class 4, transcription factor 2 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ POU domain, class 4, transcription factor 2 — molecular function (P680): DNA-binding transcription repressor activity, RNA polymerase II-specific. The ability of POU family transcription factors to activate or repress gene expression is dependent on the spacing and context of their specific response elements. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ POU domain, class 4, transcription factor 2 — molecular function (P680): DNA-binding transcription factor activity, RNA polymerase II-specific. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ POU domain, class 4, transcription factor 2 — molecular function (P680): protein binding. Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ POU domain, class 4, transcription factor 2 — molecular function (P680): sequence-specific DNA binding. Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ POU domain, class 4, transcription factor 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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MLA

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BibTeX

@misc{4ortxyz_pou-domain-class-4-transcription-factor-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{POU domain, class 4, transcription factor 2}}, year = {2026}, url = {https://4ort.xyz/entity/pou-domain-class-4-transcription-factor-2}, note = {Accessed: 2026-05-03}}

LLM prompt

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